Manteia

ENSMUSG00000059383

Mus musculus

Features

Gene ID:	ENSMUSG00000059383

Biological name :	Gfral

Synonyms :	GDNF family receptor alpha-like / Gfral / Q6SJE0

Possible biological names infered from orthology :	Q6UXV0

Species:	Mus musculus

Chr. number:	9
Strand:	-1
Band:	D
Gene start:	76164102
Gene end:	76213657

Corresponding Affymetrix probe sets:	10595050 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000074421 Ensembl peptide - ENSMUSP00000139120 NCBI entrez gene - 404194 See in Manteia. MGI - MGI:3607786 RefSeq - NM_205844 RefSeq Peptide - NP_995316 swissprot - Q6SJE0 Ensembl - ENSMUSG00000059383

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gfral	ENSDARG00000089709	Danio rerio
GFRAL	ENSGALG00000016296	Gallus gallus
GFRAL	ENSG00000187871	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR016017	GDNF/GAS1
IPR037193	GDNF receptor alpha

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0031098	stress-activated protein kinase signaling cascade	IDA
biological_process	GO:0043524	negative regulation of neuron apoptotic process	IDA
biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0003674	molecular_function	ND

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001259	abnormal body weight	"anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0001433	polyphagia	"eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0005658	susceptibility to diet-induced obesity	"more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0010358	abnormal free fatty acids level	"any anomaly in the concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0011969	abnormal circulating triglyceride level	"abnormal concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [MGI:csmith]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr