ENSMUSG00000060126


Mus musculus

Features
Gene ID: ENSMUSG00000060126
  
Biological name :Tpt1
  
Synonyms : P63028 / Tpt1 / Translationally-controlled tumor protein
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 75845093
Gene end: 75848525
  
Corresponding Affymetrix probe sets: 10416496 (MoGene1.0st)   10416503 (MoGene1.0st)   10546702 (MoGene1.0st)   10584350 (MoGene1.0st)   10601264 (MoGene1.0st)   1416642_a_at (Mouse Genome 430 2.0 Array)   1416643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121225
Ensembl peptide - ENSMUSP00000106519
NCBI entrez gene - 22070     See in Manteia.
MGI - MGI:104890
RefSeq - NM_009429
RefSeq Peptide - NP_033455
swissprot - D3YU75
swissprot - P63028
Ensembl - ENSMUSG00000060126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR339054.2ENSDARG00000109513Danio rerio
 TPT1ENSGALG00000028872Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011057  Mss4-like superfamily
 IPR018103  Translationally controlled tumour protein, conserved site
 IPR018105  Translationally controlled tumour protein
 IPR034737  Translationally controlled tumour protein (TCTP) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
 biological_processGO:2000384 negative regulation of ectoderm development IMP
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005771 multivesicular body ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0045298 tubulin complex ISO
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0008134 transcription factor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Tpt1tm1Kefu/Tpt1tm1Kefu
Genetic Background: 129S6/SvEvTac-Tpt1tm1Kefu

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Genetic Background: involves: 129S6/SvEvTac

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0011192 decreased embryonic epiblast cell proliferation "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr