ENSMUSG00000060798


Mus musculus

Features
Gene ID: ENSMUSG00000060798
  
Biological name :Intu
  
Synonyms : Intu / Protein inturned / Q059U7
  
Possible biological names infered from orthology : inturned planar cell polarity protein / Q9ULD6
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 40531286
Gene end: 40704774
  
Corresponding Affymetrix probe sets: 10491753 (MoGene1.0st)   1432781_at (Mouse Genome 430 2.0 Array)   1444272_at (Mouse Genome 430 2.0 Array)   1454350_at (Mouse Genome 430 2.0 Array)   1458595_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144877
Ensembl peptide - ENSMUSP00000054313
Ensembl peptide - ENSMUSP00000088725
NCBI entrez gene - 380614     See in Manteia.
MGI - MGI:2443752
RefSeq - NM_175515
RefSeq - XM_017319627
RefSeq - XM_017319628
RefSeq Peptide - NP_780724
swissprot - A0A0N4SUY7
swissprot - Q059U7
Ensembl - ENSMUSG00000060798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 intuENSDARG00000077639Danio rerio
 INTUENSGALG00000010170Gallus gallus
 INTUENSG00000164066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0051782 negative regulation of cell division IMP
 biological_processGO:0060173 limb development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Intutm1.2Aliu/Intutm1.2Aliu
Genetic Background: involves: 129P2/OlaHsd * C3H/HeN

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

Allelic Composition: Intudtm/Intutm1.2Aliu
Genetic Background: involves: 129P2/OlaHsd * C3H/HeN

 MP:0000785 telencephalon hypoplasia "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000831 diencephalon hyperplasia "increased cell number in the rostral portion of the brain stem" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000927 small floor plate "reduced size of the floor plate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptchd1tm2.1Gfng/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004203 abnormal cranial flexure "any structural abnormality or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [J:10730, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004574 broad limb buds "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0011065 abnormal kidney epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a kidney epithelial cell that projects into the luminal space of the tubules and ducts where it is thought to act as a flow sensor" [PMID:17995581]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011998 decreased embryonic cilium length "reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0013197 decreased embryonic cilium number "reduced number of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:anna]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0013202 abnormal cilium morphology "any structural anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole " [GO:0005929]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

 MP:0013213 abnormal embryonic neuroepithelium primary cilium morphology "any structural anomaly of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning " [PMID:23351466]
Show

Allelic Composition: Intudtm/Intudtm
Genetic Background: involves: C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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