ENSMUSG00000061244


Mus musculus

Features
Gene ID: ENSMUSG00000061244
  
Biological name :Exoc5
  
Synonyms : Exoc5 / Exocyst complex component 5 / Q3TPX4
  
Possible biological names infered from orthology : O00471
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 49004090
Gene end: 49066653
  
Corresponding Affymetrix probe sets: 10419370 (MoGene1.0st)   1436817_at (Mouse Genome 430 2.0 Array)   1438126_at (Mouse Genome 430 2.0 Array)   1440110_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124012
Ensembl peptide - ENSMUSP00000125434
Ensembl peptide - ENSMUSP00000123825
NCBI entrez gene - 105504     See in Manteia.
MGI - MGI:2145645
RefSeq - XM_011244883
RefSeq - XM_011244884
RefSeq - XM_017315766
RefSeq - NM_207214
RefSeq Peptide - NP_997097
swissprot - Q3TPX4
swissprot - E0CYX2
swissprot - E9PZ92
Ensembl - ENSMUSG00000061244
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exoc5ENSDARG00000060323Danio rerio
 EXOC5ENSGALG00000012105Gallus gallus
 EXOC5ENSG00000070367Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009976  Exocyst complex component Sec10-like
 IPR033960  Exocyst complex component EXOC5/Sec10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006893 Golgi to plasma membrane transport IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0048278 vesicle docking IEA
 cellular_componentGO:0000145 exocyst IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030496 midbody IEA
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Insulin processing
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0003587 ureter obstruction "any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0003589 abnormal ureter physiology "anomalous function of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0011426 abnormal ureter smooth muscle morphology "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0011484 abnormal ureter urothelium morphology "any structural anomaly of the epithelial lining of the luminal space of the ureter" [MGI:csmith]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0011491 ureteropelvic junction obstruction "a partial or total blockage of the flow of urine through the junction of the renal pelvis and the proximal ureter" [MGI:anna]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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