ENSMUSG00000061477


Mus musculus

Features
Gene ID: ENSMUSG00000061477
  
Biological name :Rps7
  
Synonyms : P62082 / ribosomal protein S7 / Rps7
  
Possible biological names infered from orthology : P62081
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A2
Gene start: 28630854
Gene end: 28635953
  
Corresponding Affymetrix probe sets: 10399760 (MoGene1.0st)   10461389 (MoGene1.0st)   10607391 (MoGene1.0st)   1419364_a_at (Mouse Genome 430 2.0 Array)   1435593_x_at (Mouse Genome 430 2.0 Array)   1455364_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073880
Ensembl peptide - ENSMUSP00000152456
NCBI entrez gene - 20115     See in Manteia.
MGI - MGI:1333818
RefSeq - NM_011300
RefSeq Peptide - NP_035430
swissprot - P62082
swissprot - Q4FZE6
Ensembl - ENSMUSG00000061477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps7ENSDARG00000042566Danio rerio
 RPS7ENSGALG00000016392Gallus gallus
 RPS7ENSG00000171863Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm9493ENSMUSG0000004442497


Protein motifs (from Interpro)
Interpro ID Name
 IPR000554  Ribosomal protein S7e


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0002181 cytoplasmic translation IBA
 biological_processGO:0006364 rRNA processing ISO
 biological_processGO:0006412 translation IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0042274 ribosomal small subunit biogenesis ISO
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:1904667 negative regulation of ubiquitin protein ligase activity ISO
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit IEA
 cellular_componentGO:0030686 90S preribosome IBA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032040 small-subunit processome IBA
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISO
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0008266 poly(U) RNA binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0048027 mRNA 5"-UTR binding ISO
 molecular_functionGO:1990948 ubiquitin ligase inhibitor activity ISO


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

Allelic Composition: Rps7Zma/Rps7+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Mtu/Rps7+
Genetic Background: (C3H/HeH x BALB/cOlaHsd)F1

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004600 abnormal vertebral transverse process "any structural anomaly of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004645 decreased vertebrae number "a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0009783 abnormal melanoblast morphology "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541]
Show

Allelic Composition: Rps7Zma/Rps7+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1SvJ * BALB/c * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+,Tg(Dct-lacZ)IPav/0
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J * FVB/N

 MP:0009843 decreased neural crest cell number "reduction in the number of ransient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0012533 uveal coloboma "congenital defect of the uvea in which some part of the structure is absent" [MGI:anna]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0012536 delayed optic fissure closure "late onset of the initiation and/or completion of closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk" [MGI:anna]
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Allelic Composition: Rps7Zma/Rps7+
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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