ENSMUSG00000062444


Mus musculus

Features
Gene ID: ENSMUSG00000062444
  
Biological name :Ap3b2
  
Synonyms : Ap3b2 / AP-3 complex subunit beta-2 / Q9JME5
  
Possible biological names infered from orthology : adaptor related protein complex 3 beta 2 subunit / Q13367
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 81460399
Gene end: 81493925
  
Corresponding Affymetrix probe sets: 10565102 (MoGene1.0st)   1426927_at (Mouse Genome 430 2.0 Array)   1451837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146497
Ensembl peptide - ENSMUSP00000080739
NCBI entrez gene - 11775     See in Manteia.
MGI - MGI:1100869
RefSeq - NM_021492
RefSeq - XM_006540571
RefSeq Peptide - NP_067467
swissprot - A0A140LHP9
swissprot - Q9JME5
Ensembl - ENSMUSG00000062444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO017739.1ENSDARG00000105296Danio rerio
 ENSGALG00000035202Gallus gallus
 AP3B2ENSG00000103723Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap3b1 / Q9Z1T1 / AP-3 complex subunit beta-1 / O00203* / adaptor related protein complex 3 beta 1 subunit*ENSMUSG0000002168662


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR011989  Armadillo-like helical
 IPR013037  Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR016024  Armadillo-type fold
 IPR026739  AP complex subunit beta
 IPR026740  AP-3 complex subunit beta
 IPR029390  AP-3 complex subunit beta, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0048490 anterograde synaptic vesicle transport IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030123 AP-3 adaptor complex IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

Allelic Composition: Ap3b2m1J/Ap3b2m1J
Genetic Background: C57BL/6J-Ap3b2m1J/FrkJ

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Ap3b2m1J/Ap3b2m1J
Genetic Background: C57BL/6J-Ap3b2m1J/FrkJ

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb32tm1Iho/Zbtb32tm1Iho
Genetic Background: involves: C57BL/6

Allelic Composition: Ap3b2m2J/Ap3b2m2J
Genetic Background: B6;129S-Ap3b2m2J/GrsrJ

Allelic Composition: Ap3b2m1J/Ap3b2m1J
Genetic Background: C57BL/6J-Ap3b2m1J/FrkJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ap3b2m2J/Ap3b2m2J
Genetic Background: B6;129S-Ap3b2m2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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