ENSMUSG00000063172


Mus musculus

Features
Gene ID: ENSMUSG00000063172
  
Biological name :Hspb11
  
Synonyms : Hspb11 / Mus musculus heat shock protein family B (small), member 11 (Hspb11), transcript variant 2, mRNA. / Q9D6H2
  
Possible biological names infered from orthology : heat shock protein family B (small) member 11 / Q9Y547
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 107253593
Gene end: 107279938
  
Corresponding Affymetrix probe sets: 10506658 (MoGene1.0st)   1425935_at (Mouse Genome 430 2.0 Array)   1453016_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048810
Ensembl peptide - ENSMUSP00000102360
Ensembl peptide - ENSMUSP00000118617
NCBI entrez gene - 72938     See in Manteia.
MGI - MGI:1920188
RefSeq - XM_006503426
RefSeq - NM_001355459
RefSeq - NM_001355460
RefSeq - NM_028394
RefSeq - XM_006503424
RefSeq - XM_006503425
RefSeq Peptide - NP_001342388
RefSeq Peptide - NP_001342389
RefSeq Peptide - NP_082670
swissprot - Q9D6H2
Ensembl - ENSMUSG00000063172
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:158640ENSDARG00000067777Danio rerio
 HSPB11ENSGALG00000038608Gallus gallus
 HSPB11ENSG00000081870Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008979  Galactose-binding-like domain superfamily
 IPR033558  Intraflagellar transport protein 25


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0042073 intraciliary transport IC
 biological_processGO:0070986 left/right axis specification IMP
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0030992 intraciliary transport particle B TAS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011673 unbalanced complete common atrioventricular canal 
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Hspb11tm1b(EUCOMM)Wtsi/Hspb11tm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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