ENSMUSG00000063439


Mus musculus

Features
Gene ID: ENSMUSG00000063439
  
Biological name :B9d2
  
Synonyms : B9d2 / B9 domain-containing protein 2 / Q3UK10
  
Possible biological names infered from orthology : B9 domain containing 2 / Q9BPU9
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 25680780
Gene end: 25686558
  
Corresponding Affymetrix probe sets: 10551181 (MoGene1.0st)   1427947_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145729
Ensembl peptide - ENSMUSP00000146289
Ensembl peptide - ENSMUSP00000145950
Ensembl peptide - ENSMUSP00000104040
NCBI entrez gene - 232987     See in Manteia.
MGI - MGI:2387643
RefSeq - NM_172148
RefSeq - XM_006539854
RefSeq Peptide - NP_742160
swissprot - A0A0U1RPE5
swissprot - Q3UK10
swissprot - A0A0U1RNW5
Ensembl - ENSMUSG00000063439
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b9d2ENSDARG00000017385Danio rerio
 B9D2ENSG00000123810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B9d1 / Q9R1S0 / B9 domain-containing protein 1 / Q9UPM9* / B9 domain containing 1*ENSMUSG0000000103927


Protein motifs (from Interpro)
Interpro ID Name
 IPR010796  B9 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0035869 ciliary transition zone ISO
 cellular_componentGO:0036038 MKS complex IDA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043015 gamma-tubulin binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Endogtm1Vdaw/Endogtm1Vdaw
Genetic Background: involves: 129S6/SvEvTac * ICR

Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tg(CD207-cre)1Dhka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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