ENSMUSG00000063802


Mus musculus

Features
Gene ID: ENSMUSG00000063802
  
Biological name :Hspbp1
  
Synonyms : Hsp70-binding protein 1 / Hspbp1 / Q99P31
  
Possible biological names infered from orthology : HSPA (Hsp70) binding protein 1 / Q9NZL4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4660521
Gene end: 4685068
  
Corresponding Affymetrix probe sets: 10559635 (MoGene1.0st)   1416894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078886
Ensembl peptide - ENSMUSP00000146248
Ensembl peptide - ENSMUSP00000145960
Ensembl peptide - ENSMUSP00000145954
Ensembl peptide - ENSMUSP00000145614
NCBI entrez gene - 66245     See in Manteia.
MGI - MGI:1913495
RefSeq - XM_006540288
RefSeq - NM_024172
RefSeq Peptide - NP_077134
swissprot - A0A0U1RNL5
swissprot - A0A0U1RPF2
swissprot - A0A0U1RQ49
swissprot - Q99P31
swissprot - A0A0U1RPE7
Ensembl - ENSMUSG00000063802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspbp1ENSDARG00000102937Danio rerio
 HSPBP1ENSG00000133265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR013918  Nucleotide exchange factor Fes1
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004857 enzyme inhibitor activity IBA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igfbp7tm1.1Dds/Igfbp7+
Genetic Background: involves: CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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