Manteia - Molecule gene

ENSMUSG00000063919

Mus musculus

Features

Gene ID:	ENSMUSG00000063919

Biological name :	Srrm4

Synonyms :	Q8BKA3 / serine/arginine repetitive matrix 4 / Srrm4

Possible biological names infered from orthology :	A7MD48

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	116439275
Gene end:	116591817

Corresponding Affymetrix probe sets:	10533055 (MoGene1.0st) 1425774_at (Mouse Genome 430 2.0 Array) 1435062_at (Mouse Genome 430 2.0 Array) 1438523_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000152054 Ensembl peptide - ENSMUSP00000075488 Ensembl peptide - ENSMUSP00000144367 NCBI entrez gene - 68955 See in Manteia. MGI - MGI:1916205 RefSeq - XM_006530456 RefSeq - XM_011248239 RefSeq - NM_026886 RefSeq Peptide - NP_081162 swissprot - Q8BKA3 swissprot - J9QHX6 swissprot - A0A1Y7VIM4 Ensembl - ENSMUSG00000063919

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:zfos-375h5.1	ENSDARG00000096920	Danio rerio
srrm4	ENSDARG00000086327	Danio rerio
	ENSGALG00000007388	Gallus gallus
	ENSGALG00000046119	Gallus gallus
SRRM4	ENSG00000139767	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR029360	Serine/arginine repetitive matrix protein, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IMP
biological_process	GO:0006397	mRNA processing	IEA
biological_process	GO:0007399	nervous system development	IMP
biological_process	GO:0007605	sensory perception of sound	IMP
biological_process	GO:0008380	RNA splicing	IEA
biological_process	GO:0030154	cell differentiation	IMP
biological_process	GO:0043484	regulation of RNA splicing	IDA
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0003729	mRNA binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ccna2^tm1Sot/Ccna2^tm1Sot Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000790	abnormal stratification in cerebral cortex	"abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4⁺ Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0001485	abnormal pinna reflex	"failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002623	abnormal vestibular hair cell morphology	"malformation of the sensory epithelial cells of the membraneous labyrinth of the inner ear; these cells are in synaptic contact with the vestibular nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002857	cochlear ganglion degeneration	"loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002961	abnormal axon guidance	"defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4⁺ Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0003424	premature neuronal precursor differentiation	"earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0003651	abnormal axon outgrowth	"defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0003825	abnormal pillar cell morphology	"abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004249	abnormal crista ampullaris morphology	"anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0004312	absent pillar cells	"absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004328	decreased vestibular hair cell number	"decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004333	abnormal utricular macula morphology	"any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004334	utricular macular degeneration	"degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004396	decreased cochlear inner hair cell number	"decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004397	absent cochlear inner hair cells	"absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004398	cochlear inner hair cell degeneration	"degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004518	absent vestibular hair cell stereocilia	"complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004589	abnormal cochlear hair cell development	"atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004736	abnormal distortion product otoacoustic emission	"any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005191	head tilt	"condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005307	head tossing	"compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cyp19a1^tm1Toda/Cyp19a1^tm1Toda Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0006335	abnormal hearing electrophysiology	"anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0006336	abnormal otoacoustic response	"anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cbx5^{tm1a(EUCOMM)Wtsi}/Cbx5^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cbx5^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Srrm4^bv/Srrm4^bv Genetic Background: Not Specified Allelic Composition: Srrm4^{tm1e(EUCOMM)Wtsi}/Srrm4^{tm1e(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Srrm4^{tm1e(EUCOMM)Wtsi}/Wtsi
MP:0012055	abnormal phrenic nerve innervation pattern to diaphragm	"any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]	Show Allelic Composition: Srrm4^{tm1b(EUCOMM)Wtsi}/Srrm4^{tm1b(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr