ENSMUSG00000064254


Mus musculus

Features
Gene ID: ENSMUSG00000064254
  
Biological name :Ethe1
  
Synonyms : Ethe1 / Persulfide dioxygenase ETHE1, mitochondrial / Q9DCM0
  
Possible biological names infered from orthology : ETHE1, persulfide dioxygenase / O95571
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 24587543
Gene end: 24608925
  
Corresponding Affymetrix probe sets: 10550956 (MoGene1.0st)   1417203_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076433
NCBI entrez gene - 66071     See in Manteia.
MGI - MGI:1913321
RefSeq - NM_023154
RefSeq - XM_017312221
RefSeq Peptide - NP_075643
swissprot - Q9DCM0
Ensembl - ENSMUSG00000064254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ethe1ENSDARG00000005713Danio rerio
 ETHE1ENSG00000105755Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pnkd / Q69ZP3 / paroxysmal nonkinesiogenic dyskinesia / Q8N490* / paroxysmal nonkinesigenic dyskinesia*ENSMUSG0000002617924
Hagh / hydroxyacyl glutathione hydrolase / Q16775* / hydroxyacylglutathione hydrolase*ENSMUSG0000002415823
Haghl / Q9DB32 / Hydroxyacylglutathione hydrolase-like protein / Q6PII5* / hydroxyacylglutathione hydrolase like*ENSMUSG0000006104623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001279  Metallo-beta-lactamase
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070813 hydrogen sulfide metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050313 sulfur dioxygenase activity ISO
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Sulfide oxidation to sulfate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000192 abnormal mineral level "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005803 Sqor / Q9R112 / Sulfide:quinone oxidoreductase, mitochondrial / Q9Y6N5* / AC090527.2* / sulfide quinone oxidoreductase*  / reaction






 

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