ENSMUSG00000064326


Mus musculus

Features
Gene ID: ENSMUSG00000064326
  
Biological name :Siva1
  
Synonyms : Apoptosis regulatory protein Siva / O54926 / Siva1
  
Possible biological names infered from orthology : O15304 / SIVA1 apoptosis inducing factor
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 112644679
Gene end: 112649149
  
Corresponding Affymetrix probe sets: 10398874 (MoGene1.0st)   10585395 (MoGene1.0st)   1418377_a_at (Mouse Genome 430 2.0 Array)   1426323_x_at (Mouse Genome 430 2.0 Array)   1433680_x_at (Mouse Genome 430 2.0 Array)   1452020_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021728
Ensembl peptide - ENSMUSP00000105377
NCBI entrez gene - 30954     See in Manteia.
MGI - MGI:1353606
RefSeq - NM_001161737
RefSeq - NM_013929
RefSeq Peptide - NP_001155209
RefSeq Peptide - NP_038957
swissprot - O54926
Ensembl - ENSMUSG00000064326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 siva1ENSDARG00000114552Danio rerio
 SIVA1ENSGALG00000011619Gallus gallus
 SIVA1ENSG00000184990Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022773  Siva


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006924 activation-induced cell death of T cells ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IPI
 molecular_functionGO:0005175 CD27 receptor binding IPI
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw

Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snai1tm1.1Stjw/Snai1tm1.1Stjw,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.1Att/Siva1tm1.2Att
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020190 abnormal lung adenoma incidence "an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period" [GOC:NV]
Show

Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.1Att/Siva1tm1.2Att
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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