| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
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| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0001442 | decreased grooming behavior | "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv *129X1/SvJ * Swiss Webster
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| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv *129X1/SvJ * Swiss Webster
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Cebpdtm1Pfj/Cebpd+
Genetic Background: involves: 129S1/Sv
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| MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0001775 | abnormal selenium level | "anomalous concentration of this essential trace element, required for glutathione peroxidase and other enzymes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
Allelic Composition: Gpx3tm1Hjco/Gpx3tm1Hjco,Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
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| MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv *129X1/SvJ * Swiss Webster
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| MP:0002068 | abnormal parental behavior | "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J
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| MP:0002687 | oligozoospermia | "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
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| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0003325 | decreased liver function | "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0005027 | increased susceptibility to parasitic infection | "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0005578 | teratozoospermia | "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0008892 | abnormal sperm flagellum | "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0009243 | hairpin sperm flagellum | "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0009831 | abnormal sperm midpiece morphology | "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0009832 | abnormal sperm mitochondrial sheath morphology | "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499] |
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Allelic Composition: Selenoptm2Rfb/Selenoptm2Rfb
Genetic Background: B6.Cg-Selenoptm2Rfb
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: B6.129-Selenoptm1Rfb
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| MP:0010180 | increased susceptibility to weight loss | "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011770 | increased urine selenium level | "greater than normal amount of selenium in the urine" [MGI:anna] |
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
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