ENSMUSG00000066383


Mus musculus

Features
Gene ID: ENSMUSG00000066383
  
Biological name :Iqcf1
  
Synonyms : Iqcf1 / IQ domain-containing protein F1 / Q9D9K8
  
Possible biological names infered from orthology : IQ motif containing F1 / Q8N6M8
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 106499967
Gene end: 106502254
  
Corresponding Affymetrix probe sets: 10588538 (MoGene1.0st)   1430002_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149801
Ensembl peptide - ENSMUSP00000082195
Ensembl peptide - ENSMUSP00000126039
NCBI entrez gene - 74267     See in Manteia.
MGI - MGI:1921517
RefSeq - NM_001146701
RefSeq - NM_028843
RefSeq Peptide - NP_001140173
RefSeq Peptide - NP_083119
swissprot - A0A1L1SS97
swissprot - Q9D9K8
Ensembl - ENSMUSG00000066383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IQCF1ENSG00000173389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iqcf5 / Q9DAL7 / IQ domain-containing protein F5 / A8MTL0* / IQ motif containing F5*ENSMUSG0000006638244
Iqcf4ENSMUSG0000004100941
Iqcf6 / IQ motif containing F6 / A8MYZ5*ENSMUSG0000009112932
Iqcf3 / Q9D498 / IQ domain-containing protein F3 ENSMUSG0000002357721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060474 positive regulation of flagellated sperm motility involved in capacitation IMP
 biological_processGO:2000344 positive regulation of acrosome reaction IMP
 cellular_componentGO:0001669 acrosomal vesicle ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shhtm1Chg/Shh+,Vps25m1Lis/Vps25m1Lis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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