ENSMUSG00000066440


Mus musculus

Features
Gene ID: ENSMUSG00000066440
  
Biological name :Zfyve26
  
Synonyms : Q5DU37 / Zfyve26 / zinc finger, FYVE domain containing 26
  
Possible biological names infered from orthology : Q68DK2 / zinc finger FYVE-type containing 26
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 79232346
Gene end: 79296304
  
Corresponding Affymetrix probe sets: 10401192 (MoGene1.0st)   1452306_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151290
Ensembl peptide - ENSMUSP00000021547
Ensembl peptide - ENSMUSP00000151280
NCBI entrez gene - 211978     See in Manteia.
MGI - MGI:1924767
RefSeq - XM_017315014
RefSeq - XM_006515649
RefSeq - XM_017315011
RefSeq - XM_017315012
RefSeq - XM_017315013
RefSeq - NM_001008550
RefSeq - XM_006515647
RefSeq Peptide - NP_001008550
swissprot - A0A1W2P6K6
swissprot - A0A1W2P6J0
swissprot - Q5DU37
Ensembl - ENSMUSG00000066440
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfyve26ENSDARG00000040131Danio rerio
 ZFYVE26ENSGALG00000028762Gallus gallus
 Q68DK2ENSG00000072121Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016024  Armadillo-type fold
 IPR017455  Zinc finger, FYVE-related
 IPR028730  Zinc finger FYVE domain-containing protein 26


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030496 midbody ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Whrnhb/Whrnhb
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0002946 delayed axon outgrowth "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Whrnhb/Whrnhb
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0011874 enlarged urinary bladder "increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [MGI:Colin_McKerlie]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Smarcd2tm1.1(KOMP)Vlcg/Smarcd2+
Genetic Background: C57BL/6N-Smarcd2tm1.1(KOMP)Vlcg/Ucd

 MP:0012506 brain atrophy "acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr