ENSMUSG00000067773


Mus musculus

Features
Gene ID: ENSMUSG00000067773
  
Biological name :Defb41
  
Synonyms : Beta-defensin 41 / Defb41 / Q30KP6
  
Possible biological names infered from orthology : DEFB110 / defensin beta 110 / Q30KQ9
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 18250980
Gene end: 18265138
  
Corresponding Affymetrix probe sets: 10353336 (MoGene1.0st)   1440767_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085811
Ensembl peptide - ENSMUSP00000095426
NCBI entrez gene - 77673     See in Manteia.
MGI - MGI:1924923
RefSeq - NM_001040027
RefSeq - NM_183124
RefSeq Peptide - NP_001035116
RefSeq Peptide - NP_898947
swissprot - Q30KP6
Ensembl - ENSMUSG00000067773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q30KQ9ENSG00000203970Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR025933  Beta-defensin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Beta defensins
Defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dag1tm1.1Swin/Dag1tm1.1Swin,Dmdmdx/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0004728 abnormal efferent ductules of testis "any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0009140 dilated efferent ductules of testis "an expansion in the volume or area of the lumen of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0014194 increased epididymal epithelium cell proliferation "increase in the expansion rate of the cells of the epididymal epithelium by cell division" [MGI:Anna]
Show

Allelic Composition: Defb41tm1(icre)Psip/Defb41+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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