ENSMUSG00000068394


Mus musculus

Features
Gene ID: ENSMUSG00000068394
  
Biological name :Cep152
  
Synonyms : A2AUM9 / Centrosomal protein of 152 kDa / Cep152
  
Possible biological names infered from orthology : centrosomal protein 152 / O94986
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 125563088
Gene end: 125625113
  
Corresponding Affymetrix probe sets: 10487109 (MoGene1.0st)   1427496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087208
NCBI entrez gene - 99100     See in Manteia.
MGI - MGI:2139083
RefSeq - XM_017319354
RefSeq - NM_001081091
RefSeq - XM_011239870
RefSeq - XM_011239871
RefSeq - XM_006500473
RefSeq - XM_006500474
RefSeq Peptide - NP_001074560
swissprot - A2AUM9
Ensembl - ENSMUSG00000068394
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cep152ENSDARG00000075725Danio rerio
 ENSGALG00000042025Gallus gallus
 CEP152ENSG00000103995Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029598  Centrosomal protein of 152kDa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007099 centriole replication IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0098536 deuterosome IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

 MP:0013214 decreased embryonic neuroepithelium primary cilium number "reduced number of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning " [PMID:23351466]
Show

Allelic Composition: Cenpjtm1d(EUCOMM)Wtsi/Cenpjtm1d(EUCOMM)Wtsi,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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