ENSMUSG00000068663


Mus musculus

Features
Gene ID: ENSMUSG00000068663
  
Biological name :Clec16a
  
Synonyms : Clec16a / Protein CLEC16A / Q80U30
  
Possible biological names infered from orthology : C-type lectin domain containing 16A / Q2KHT3
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 10545339
Gene end: 10744878
  
Corresponding Affymetrix probe sets: 10433536 (MoGene1.0st)   1453635_at (Mouse Genome 430 2.0 Array)   1455326_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123189
Ensembl peptide - ENSMUSP00000111494
Ensembl peptide - ENSMUSP00000114577
Ensembl peptide - ENSMUSP00000040267
Ensembl peptide - ENSMUSP00000065423
Ensembl peptide - ENSMUSP00000111489
Ensembl peptide - ENSMUSP00000111490
Ensembl peptide - ENSMUSP00000111493
NCBI entrez gene - 74374     See in Manteia.
MGI - MGI:1921624
RefSeq - NM_177562
RefSeq - XM_006522663
RefSeq - XM_006522664
RefSeq - XM_006522665
RefSeq - XM_011246027
RefSeq - XM_017317148
RefSeq - XM_017317149
RefSeq - NM_001204229
RefSeq - XM_006522660
RefSeq - XM_006522661
RefSeq - XM_006522662
RefSeq Peptide - NP_001191158
RefSeq Peptide - NP_808230
swissprot - H7BXB6
swissprot - Z4YLG3
swissprot - D3YVA1
swissprot - Q80U30
Ensembl - ENSMUSG00000068663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clec16aENSDARG00000038094Danio rerio
 CLEC16AENSGALG00000007167Gallus gallus
 Q2KHT3ENSG00000038532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR019155  CLEC16A/TT9, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:1901097 negative regulation of autophagosome maturation ISO
 biological_processGO:1901098 positive regulation of autophagosome maturation IMP
 biological_processGO:1901525 negative regulation of mitophagy IMP
 biological_processGO:1904263 positive regulation of TORC1 signaling ISO
 biological_processGO:1904766 negative regulation of macroautophagy by TORC1 signaling ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0036020 endolysosome membrane IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
Show

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0013179 wavy tail "undulations or a sinusoidal shape of the tail" [MGI:anna]
Show

Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0014046 abnormal mitophagy "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996]
Show

Allelic Composition: Appl1tm1.2Test/Appl1tm1.2Test,Appl2tm1.1Test/Appl2tm1.1Test
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Clec16atm1.1Hhak/Clec16atm1.1Hhak,Tg(Pdx1-cre)1Herr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr