ENSMUSG00000068876


Mus musculus

Features
Gene ID: ENSMUSG00000068876
  
Biological name :Cgn
  
Synonyms : Cgn / cingulin
  
Possible biological names infered from orthology : Q9P2M7
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 94760069
Gene end: 94786492
  
Corresponding Affymetrix probe sets: 10500021 (MoGene1.0st)   1430329_at (Mouse Genome 430 2.0 Array)   1435155_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102893
Ensembl peptide - ENSMUSP00000143156
Ensembl peptide - ENSMUSP00000142809
Ensembl peptide - ENSMUSP00000102894
NCBI entrez gene - 70737     See in Manteia.
MGI - MGI:1927237
RefSeq - XM_006502062
RefSeq - NM_001037711
RefSeq - NM_001293727
RefSeq - XM_006502061
RefSeq Peptide - NP_001280656
RefSeq Peptide - NP_001032800
swissprot - E9QMC1
swissprot - A0A0G2JFG0
swissprot - A0A0G2JEK8
swissprot - D3YUW7
Ensembl - ENSMUSG00000068876
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cgnaENSDARG00000055607Danio rerio
 cgnbENSDARG00000058690Danio rerio
 CGNENSGALG00000000920Gallus gallus
 CGNENSG00000143375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cgnl1 / cingulin like 1 / Q0VF96*ENSMUSG0000003223230


Protein motifs (from Interpro)
Interpro ID Name
 IPR002928  Myosin tail


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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