ENSMUSG00000069763


Mus musculus

Features
Gene ID: ENSMUSG00000069763
  
Biological name :Tmem100
  
Synonyms : Q9CQG9 / Tmem100 / Transmembrane protein 100
  
Possible biological names infered from orthology : Q9NV29
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 90030348
Gene end: 90036508
  
Corresponding Affymetrix probe sets: 10380285 (MoGene1.0st)   1446625_at (Mouse Genome 430 2.0 Array)   1449533_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090464
NCBI entrez gene - 67888     See in Manteia.
MGI - MGI:1915138
RefSeq - XM_006534031
RefSeq - NM_026433
RefSeq - XM_006534030
RefSeq Peptide - NP_080709
swissprot - Q9CQG9
Ensembl - ENSMUSG00000069763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TMEM100ENSGALG00000026465Gallus gallus
 Q9NV29ENSG00000166292Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR032536  Transmembrane protein 100


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IMP
 biological_processGO:0050848 regulation of calcium-mediated signaling IMP
 biological_processGO:0051930 regulation of sensory perception of pain IMP
 biological_processGO:0060842 arterial endothelial cell differentiation IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2001214 positive regulation of vasculogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043204 perikaryon ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0000262 poor arterial differentiation "failure of or inadequate acquisition of the characteristics and/or functions of the arteries" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
Show

Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr1tm1.1Dhm/Ryr1+
Genetic Background: involves: 129S2/SvPasCrl * 129S6/SvEvTac

Allelic Composition: Tmem100tm1Yjl/Tmem100tm1.1Yjl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thratm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/J

 MP:0010545 abnormal heart layer morphology "any structural anomaly of the laminar structure of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ryr1tm1.1Dhm/Ryr1+
Genetic Background: involves: 129S2/SvPasCrl * 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr