ENSMUSG00000070733


Mus musculus

Features
Gene ID: ENSMUSG00000070733
  
Biological name :Fryl
  
Synonyms : Fryl / FRY like transcription coactivator
  
Possible biological names infered from orthology : O94915
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.2
Gene start: 73019987
Gene end: 73256619
  
Corresponding Affymetrix probe sets: 10530563 (MoGene1.0st)   10530592 (MoGene1.0st)   10530612 (MoGene1.0st)   10338601 (MoGene1.0st)   10339653 (MoGene1.0st)   10339656 (MoGene1.0st)   10339756 (MoGene1.0st)   10340060 (MoGene1.0st)   10340219 (MoGene1.0st)   10340319 (MoGene1.0st)   10340406 (MoGene1.0st)   10340423 (MoGene1.0st)   10340566 (MoGene1.0st)   10340606 (MoGene1.0st)   10341057 (MoGene1.0st)   10341185 (MoGene1.0st)   10341749 (MoGene1.0st)   10342053 (MoGene1.0st)   10342229 (MoGene1.0st)   10342405 (MoGene1.0st)   10338107 (MoGene1.0st)   10339179 (MoGene1.0st)   10339493 (MoGene1.0st)   10339796 (MoGene1.0st)   10340221 (MoGene1.0st)   10340289 (MoGene1.0st)   10341223 (MoGene1.0st)   10341910 (MoGene1.0st)   10342293 (MoGene1.0st)   10342633 (MoGene1.0st)   10342883 (MoGene1.0st)   10343266 (MoGene1.0st)   10343750 (MoGene1.0st)   1415758_at (Mouse Genome 430 2.0 Array)   1427199_at (Mouse Genome 430 2.0 Array)   1444520_at (Mouse Genome 430 2.0 Array)   1458233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143824
Ensembl peptide - ENSMUSP00000135794
Ensembl peptide - ENSMUSP00000143983
Ensembl peptide - ENSMUSP00000144215
Ensembl peptide - ENSMUSP00000144183
Ensembl peptide - ENSMUSP00000092289
Ensembl peptide - ENSMUSP00000098687
Ensembl peptide - ENSMUSP00000115208
Ensembl peptide - ENSMUSP00000119385
NCBI entrez gene - 72313     See in Manteia.
MGI - MGI:1919563
RefSeq - XM_017321111
RefSeq - XM_006504144
RefSeq - XM_006504145
RefSeq - XM_006504146
RefSeq - XM_006504148
RefSeq - XM_006504149
RefSeq - XM_006504150
RefSeq - XM_006504152
RefSeq - XM_011240773
RefSeq - XM_017321110
RefSeq - NM_028194
RefSeq - XM_006504137
RefSeq - XM_006504138
RefSeq - XM_006504139
RefSeq - XM_006504140
RefSeq - XM_006504141
RefSeq - XM_006504142
RefSeq - XM_006504143
RefSeq Peptide - NP_082470
swissprot - A0A0J9YUH4
swissprot - F6Q1V8
swissprot - F6SDM9
swissprot - A0A0J9YUJ6
swissprot - H3BLH9
swissprot - A0A0J9YU33
swissprot - A0A0J9YTS1
swissprot - F8VQ05
Ensembl - ENSMUSG00000070733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frylENSDARG00000040001Danio rerio
 FRYLENSGALG00000014103Gallus gallus
 FRYLENSG00000075539Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fry / E9Q8I9 / FRY microtubule binding protein / Q5TBA9*ENSMUSG0000005660260


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR025481  Cell morphogenesis protein C-terminal
 IPR025614  Cell morphogenesis protein N-terminal
 IPR029473  Cell morphogenesis central region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IBA
 biological_processGO:0031175 neuron projection development IBA
 biological_processGO:0090527 actin filament reorganization IBA
 cellular_componentGO:0005938 cell cortex IBA
 cellular_componentGO:0030427 site of polarized growth IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Fbxw7tm1Iken/Fbxw7tm1Iken,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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