ENSMUSG00000071708


Mus musculus

Features
Gene ID: ENSMUSG00000071708
  
Biological name :Sms
  
Synonyms : P97355 / Sms / Spermine synthase
  
Possible biological names infered from orthology : P52788
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F4
Gene start: 157443855
Gene end: 157492287
  
Corresponding Affymetrix probe sets: 10604844 (MoGene1.0st)   10607524 (MoGene1.0st)   1421052_a_at (Mouse Genome 430 2.0 Array)   1428699_at (Mouse Genome 430 2.0 Array)   1434190_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115810
Ensembl peptide - ENSMUSP00000108148
Ensembl peptide - ENSMUSP00000131254
NCBI entrez gene - 20603     See in Manteia.
NCBI entrez gene - 671878     See in Manteia.
MGI - MGI:109490
RefSeq - NM_009214
RefSeq - XM_006528775
RefSeq Peptide - NP_033240
swissprot - E9PZ58
swissprot - P97355
swissprot - A2AC81
Ensembl - ENSMUSG00000071708
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smsENSDARG00000008155Danio rerio
 SMSENSGALG00000016379Gallus gallus
 SMSENSG00000102172Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015576  Spermine synthase, animal
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030373  Polyamine biosynthesis domain, conserved site
 IPR030374  Polyamine biosynthesis domain
 IPR035246  Spermidine synthase, tetramerisation domain
 IPR037163  Spermidine synthase, tetramerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006596 polyamine biosynthetic process IEA
 biological_processGO:0006597 spermine biosynthetic process IEA
 biological_processGO:0008215 spermine metabolic process IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016768 spermine synthase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of polyamines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic Background: B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc38a10tm1a(EUCOMM)Wtsi/Slc38a10tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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