ENSMUSG00000072582


Mus musculus

Features
Gene ID: ENSMUSG00000072582
  
Biological name :Ptrh2
  
Synonyms : Peptidyl-tRNA hydrolase 2, mitochondrial / Ptrh2 / Q8R2Y8
  
Possible biological names infered from orthology : peptidyl-tRNA hydrolase 2 / Q9Y3E5
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 86683985
Gene end: 86692457
  
Corresponding Affymetrix probe sets: 10379981 (MoGene1.0st)   1451845_a_at (Mouse Genome 430 2.0 Array)   1455894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103656
Ensembl peptide - ENSMUSP00000103657
NCBI entrez gene - 217057     See in Manteia.
MGI - MGI:2444848
RefSeq - NM_001098810
RefSeq - NM_175004
RefSeq Peptide - NP_001092280
RefSeq Peptide - NP_778169
swissprot - Q8R2Y8
Ensembl - ENSMUSG00000072582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptrh2ENSDARG00000077339Danio rerio
 PTRH2ENSGALG00000005150Gallus gallus
 PTRH2ENSG00000141378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002833  Peptidyl-tRNA hydrolase, PTH2
 IPR023476  Peptidyl-tRNA hydrolase II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:2000210 positive regulation of anoikis ISO
 biological_processGO:2000811 negative regulation of anoikis ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004045 aminoacyl-tRNA hydrolase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1atg/Cacna1atg
Genetic Background: involves: 101 * C3H * C57BL/10 * DBA/2J

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0004248 abnormal epaxial muscle morphology "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0014185 cerebellum atrophy "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Ptrh2tm1Eruo/Ptrh2tm1.1Eruo
Genetic Background: B6.Cg-Ptrh2tm1Eruo Ptrh2tm1.1Eruo Meox2tm1(cre)Sor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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