ENSMUSG00000073102


Mus musculus

Features
Gene ID: ENSMUSG00000073102
  
Biological name :Drc1
  
Synonyms : Drc1 / Dynein regulatory complex protein 1 / Q3USS3
  
Possible biological names infered from orthology : dynein regulatory complex subunit 1 / Q96MC2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 30281388
Gene end: 30366695
  
Corresponding Affymetrix probe sets: 10520499 (MoGene1.0st)   1455279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098992
NCBI entrez gene - 381738     See in Manteia.
MGI - MGI:2685906
RefSeq - XM_017320955
RefSeq - NM_001033460
RefSeq - XM_017320953
RefSeq - XM_017320954
RefSeq Peptide - NP_001028632
swissprot - Q3USS3
Ensembl - ENSMUSG00000073102
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drc1ENSDARG00000042182Danio rerio
 DRC1ENSGALG00000016591Gallus gallus
 DRC1ENSG00000157856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029440  Dynein regulatory complex protein 1, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0060285 cilium-dependent cell motility IEA
 biological_processGO:0070286 axonemal dynein complex assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

Allelic Composition: Drc1b2b2237Clo/Drc1b2b2237Clo
Genetic Background: C57BL/6J-Drc1b2b2237Clo

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0010439 abnormal hepatic vein morphology "any structural anomaly of the veins that drain blood from the liver and terminate in three large openings to the inferior vena cava below the diaphragm and into smaller openings in more inferior positions" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0011249 abdominal situs inversus "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]
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Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

Allelic Composition: Drc1b2b2237Clo/Drc1b2b2237Clo
Genetic Background: C57BL/6J-Drc1b2b2237Clo

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

Allelic Composition: Drc1b2b2237Clo/Drc1b2b2237Clo
Genetic Background: C57BL/6J-Drc1b2b2237Clo

 MP:0011253 situs inversus with levocardia "situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0011569 abnormal azygos vein morphology "any structural anomaly of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava" [MGI:anna]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0011659 interrupted aortic arch, type b "complete discontinuation/blockage between the ascending and descending aorta with the interruption located between second carotid artery and ipsilateral subclavian artery" [MGI:csmith]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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