ENSMUSG00000074435


Mus musculus

Features
Gene ID: ENSMUSG00000074435
  
Biological name :Smcp
  
Synonyms : P15265 / Smcp / sperm mitochondria-associated cysteine-rich protein
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 92583867
Gene end: 92588997
  
Corresponding Affymetrix probe sets: 10499906 (MoGene1.0st)   1418358_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096487
Ensembl peptide - ENSMUSP00000142023
NCBI entrez gene - 17235     See in Manteia.
MGI - MGI:96945
RefSeq - NM_008574
RefSeq Peptide - NP_032600
swissprot - P15265
Ensembl - ENSMUSG00000074435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida IGI
 biological_processGO:0007341 penetration of zona pellucida IMP
 biological_processGO:0030317 flagellated sperm motility IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1ttm1Drab/Hist1h1t+,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1atm1Drab/Hist1h1a+,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bace1tm2Slr/Bace1tm2Slr
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1ttm1Drab/Hist1h1ttm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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