Manteia

ENSMUSG00000074733

Mus musculus

Features

Gene ID:	ENSMUSG00000074733

Biological name :	Zfp950

Synonyms :	Zfp950 / zinc finger protein 950

Possible biological names infered from orthology :

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	D3
Gene start:	61053840
Gene end:	61140840

Corresponding Affymetrix probe sets:	10468881 (MoGene1.0st) 10468885 (MoGene1.0st) 1428748_at (Mouse Genome 430 2.0 Array) 1436072_at (Mouse Genome 430 2.0 Array) 1438465_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000145915 Ensembl peptide - ENSMUSP00000146243 Ensembl peptide - ENSMUSP00000146206 Ensembl peptide - ENSMUSP00000146094 Ensembl peptide - ENSMUSP00000145979 Ensembl peptide - ENSMUSP00000145951 Ensembl peptide - ENSMUSP00000145648 Ensembl peptide - ENSMUSP00000145709 Ensembl peptide - ENSMUSP00000145786 NCBI entrez gene - 414758 See in Manteia. MGI - MGI:2652824 RefSeq - XM_017318247 RefSeq - NM_001001737 RefSeq - NM_001309195 RefSeq - NM_001309216 RefSeq Peptide - NP_001296124 RefSeq Peptide - NP_001296145 RefSeq Peptide - NP_001001737 swissprot - A0A0U1RQ46 swissprot - O88244 swissprot - A0A0U1RPH0 swissprot - A0A0U1RP12 swissprot - A0A0U1RPR9 swissprot - A0A0U1RNP3 swissprot - Q8BL88 swissprot - Q8C118 Ensembl - ENSMUSG00000074733

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name

Species

No match

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gm10324 / Mus musculus predicted 10324 (Gm10324), mRNA.	ENSMUSG00000095909	62
Gm17655	ENSMUSG00000090963	57
Gm14443	ENSMUSG00000078902	56
Gm35315	ENSMUSG00000109771	56
Gm14412	ENSMUSG00000078868	56
Zfp97 / zinc finger protein 97	ENSMUSG00000095990	55
Gm20939 / uncharacterized protein LOC100044193	ENSMUSG00000095193	55
Gm14434	ENSMUSG00000078881	54
Gm14305 / predicted, OTTMUSG00000016609	ENSMUSG00000078878	54
Gm14308	ENSMUSG00000078880	54
Gm4631 / predicted gene 4631	ENSMUSG00000078899	54
Gm4724 / predicted gene 4724	ENSMUSG00000078897	54
Gm2007	ENSMUSG00000094932	54
Gm2026	ENSMUSG00000078886	54
Zfp971 / zinc finger protein 971	ENSMUSG00000074519	54
Gm11007	ENSMUSG00000094475	54
Gm15446	ENSMUSG00000090015	53
Gm14326	ENSMUSG00000078862	53
Gm14419	ENSMUSG00000078875	53
Gm2004	ENSMUSG00000095648	53

Protein motifs (from Interpro)

Interpro ID	Name
IPR001909	Krueppel-associated box
IPR013087	Zinc finger C2H2-type
IPR036051	KRAB domain superfamily
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001570	vasculogenesis	IMP
biological_process	GO:0001822	kidney development	IMP
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006807	nitrogen compound metabolic process	IMP
biological_process	GO:0009791	post-embryonic development	IMP
biological_process	GO:0014909	smooth muscle cell migration	IMP
biological_process	GO:0030097	hemopoiesis	IMP
biological_process	GO:0035264	multicellular organism growth	IMP
biological_process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP
biological_process	GO:0048705	skeletal system morphogenesis	IMP
biological_process	GO:0048745	smooth muscle tissue development	IMP
biological_process	GO:0060021	roof of mouth development	IMP
biological_process	GO:0060325	face morphogenesis	IMP
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005622	intracellular	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000097	short maxilla	"reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor} Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0000431	absent palatine shelf	"missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor} Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0000767	abnormal smooth muscle morphology	"anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0001255	decreased body height	"decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0003755	abnormal palate	"anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0004471	short nasal bone	"reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0009895	decreased palatine shelf size	"reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0030189	broad snout	"increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0030383	small presphenoid bone	"reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [MGI:anna]	Show Allelic Composition: Trp53^tm1Att/Trp53^tm1Att Genetic Background: involves: 129S4/SvJae

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr