ENSMUSG00000075419


Mus musculus

Features
Gene ID: ENSMUSG00000075419
  
Biological name :Dolk
  
Synonyms : Dolichol kinase / Dolk / Q8R2Y3
  
Possible biological names infered from orthology : Q9UPQ8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 30284231
Gene end: 30286334
  
Corresponding Affymetrix probe sets: 10481453 (MoGene1.0st)   1424366_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097792
NCBI entrez gene - 227697     See in Manteia.
MGI - MGI:2677836
RefSeq - NM_177648
RefSeq Peptide - NP_808316
swissprot - Q8R2Y3
Ensembl - ENSMUSG00000075419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dolkENSDARG00000076991Danio rerio
 DOLKENSGALG00000026007Gallus gallus
 DOLKENSG00000175283Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026566  Dolichol kinase
 IPR032974  Polyprenol kinase family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043048 dolichyl monophosphate biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0004168 dolichol kinase activity ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of Dolichyl-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Chn1em1(IMPC)J/Chn1+
Genetic Background: C57BL/6NJ-Chn1em1(IMPC)J/J

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0003360 depression-related behavior 
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Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Chn1em1(IMPC)J/Chn1+
Genetic Background: C57BL/6NJ-Chn1em1(IMPC)J/J

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chn1em1(IMPC)J/Chn1+
Genetic Background: C57BL/6NJ-Chn1em1(IMPC)J/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Glt8d2tm1Lex/Glt8d2tm1Lex
Genetic Background: B6;129S5-Glt8d2tm1Lex/Mmucd

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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