ENSMUSG00000075700


Mus musculus

Features
Gene ID: ENSMUSG00000075700
  
Biological name :Selenot
  
Synonyms : P62342 / Selenot / Thioredoxin reductase-like selenoprotein T
  
Possible biological names infered from orthology : P62341 / selenoprotein T
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: D
Gene start: 58576636
Gene end: 58593133
  
Corresponding Affymetrix probe sets: 10492220 (MoGene1.0st)   1430988_at (Mouse Genome 430 2.0 Array)   1452167_at (Mouse Genome 430 2.0 Array)   1453726_s_at (Mouse Genome 430 2.0 Array)   1453778_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103557
NCBI entrez gene - 69227     See in Manteia.
MGI - MGI:1916477
RefSeq - NM_001040396
RefSeq Peptide - NP_001035486
swissprot - P62342
Ensembl - ENSMUSG00000075700
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PHY8ENSDARG00000027595Danio rerio
 Q802F2ENSDARG00000058354Danio rerio
 SELENOTENSGALG00000010399Gallus gallus
 P62341ENSG00000198843Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011893  Selenoprotein, Rdx-type
 IPR019389  Selenoprotein T
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045454 cell redox homeostasis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion ISS
 biological_processGO:0098869 cellular oxidant detoxification ISS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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