ENSMUSG00000076439


Mus musculus

Features
Gene ID: ENSMUSG00000076439
  
Biological name :Mog
  
Synonyms : Mog / myelin oligodendrocyte glycoprotein
  
Possible biological names infered from orthology : Q16653
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 37010743
Gene end: 37023398
  
Corresponding Affymetrix probe sets: 10450845 (MoGene1.0st)   1448768_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099726
Ensembl peptide - ENSMUSP00000129489
NCBI entrez gene - 17441     See in Manteia.
MGI - MGI:97435
RefSeq - XM_017317277
RefSeq - NM_010814
RefSeq - XM_006523768
RefSeq Peptide - NP_034944
swissprot - Q3UY21
swissprot - Q29ZQ5
Ensembl - ENSMUSG00000076439
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cabz01076234.2ENSDARG00000067794Danio rerio
 zgc:175177ENSDARG00000102296Danio rerio
 ENSGALG00000032221Gallus gallus
 ENSGALG00000044555Gallus gallus
 ENSGALG00000044802Gallus gallus
 ENSGALG00000039480Gallus gallus
 ENSGALG00000028157Gallus gallus
 ENSGALG00000045523Gallus gallus
 ENSGALG00000024357Gallus gallus
 ENSGALG00000040101Gallus gallus
 ENSGALG00000022875Gallus gallus
 ENSGALG00000024365Gallus gallus
 ENSGALG00000045233Gallus gallus
 BG1ENSGALG00000026396Gallus gallus
 MOGENSG00000204655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR016663  Myelin-oligodendrocyte glycoprotein
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca12el12/Abca12+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abca12el12/Abca12+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

Allelic Composition: Mogtm1Reid/Mogtm1Reid
Genetic Background: 129/Sv-Mogtm1Reid

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Mogtm1(cre)Gkl/Mogtm1(cre)Gkl,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Rag2tm1Cgn/Rag2tm1Cgn,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6

Allelic Composition: Fastm1Cgn/Fastm1Cgn,Mogtm1(cre)Gkl/Mog+,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0
Genetic Background: SJL.Cg-Mogtm1Dpd Tg(H2-Kb-Tcra,-Tcrb)1640Kurs

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Igh-Jtm1Aigl/Igh-J+,Mogtm1Dpd/Mogtm1Dpd,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Mogtm1Reid/Mogtm1Reid
Genetic Background: 129/Sv-Mogtm1Reid

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mogtm1Reid/Mogtm1Reid
Genetic Background: 129/Sv-Mogtm1Reid

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Mogtm1(cre)Gkl/Mog+
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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