ENSMUSG00000078794


Mus musculus

Features
Gene ID: ENSMUSG00000078794
  
Biological name :Dact3
  
Synonyms : Dact3 / Dapper homolog 3 / Q0PHV7
  
Possible biological names infered from orthology : dishevelled binding antagonist of beta catenin 3 / Q96B18
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16875317
Gene end: 16887462
  
Corresponding Affymetrix probe sets: 10550383 (MoGene1.0st)   1434415_at (Mouse Genome 430 2.0 Array)   1438457_at (Mouse Genome 430 2.0 Array)   1440031_at (Mouse Genome 430 2.0 Array)   1443805_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104133
NCBI entrez gene - 629378     See in Manteia.
MGI - MGI:3654828
RefSeq - NM_001081655
RefSeq Peptide - NP_001075124
swissprot - Q0PHV7
Ensembl - ENSMUSG00000078794
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dact3aENSDARG00000087910Danio rerio
 DACT3ENSG00000197380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024843  Dapper
 IPR024844  Dact3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051018 protein kinase A binding IDA
 molecular_functionGO:0070097 delta-catenin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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