ENSMUSG00000079562


Mus musculus

Features
Gene ID: ENSMUSG00000079562
  
Biological name :Maea
  
Synonyms : Macrophage erythroblast attacher / Maea / Q4VC33
  
Possible biological names infered from orthology : Q7L5Y9
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 33335509
Gene end: 33373296
  
Corresponding Affymetrix probe sets: 10521057 (MoGene1.0st)   1423031_at (Mouse Genome 430 2.0 Array)   1438903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110093
Ensembl peptide - ENSMUSP00000144587
Ensembl peptide - ENSMUSP00000144584
Ensembl peptide - ENSMUSP00000144238
NCBI entrez gene - 59003     See in Manteia.
MGI - MGI:1891748
RefSeq - XM_006504041
RefSeq - NM_021500
RefSeq Peptide - NP_067475
swissprot - A0A0J9YVB4
swissprot - A0A0J9YVB7
swissprot - Q4VC33
swissprot - A0A0J9YUL5
Ensembl - ENSMUSG00000079562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maeaENSDARG00000053691Danio rerio
 MAEAENSGALG00000013310Gallus gallus
 MAEAENSG00000090316Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006594  LIS1 homology motif
 IPR006595  CTLH, C-terminal LisH motif
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013144  CRA domain
 IPR024964  CTLH/CRA C-terminal to LisH motif domain
 IPR027714  Protein Fyv10/Macrophage erythroblast attacher


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043249 erythrocyte maturation IEA
 biological_processGO:0045721 negative regulation of gluconeogenesis IEA
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0048822 enucleate erythrocyte development IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005826 actomyosin contractile ring IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0034657 GID complex IBA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0005387 immune system phenotype 
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0013520 increased CD4-positive NK T cell number "increase in the number of CD4-positive NK T cells" [MGI:Saran]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0013523 increased memory-marker CD4-positive NK T cell number "increase in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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