ENSMUSG00000079681


Mus musculus

Features
Gene ID: ENSMUSG00000079681
  
Biological name :Zglp1
  
Synonyms : Q1WG82 / Zglp1 / zinc finger, GATA-like protein 1
  
Possible biological names infered from orthology : P0C6A0
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21062393
Gene end: 21067093
  
Corresponding Affymetrix probe sets: 10591418 (MoGene1.0st)   1446427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111157
NCBI entrez gene - 100009600     See in Manteia.
MGI - MGI:3696042
RefSeq - NM_001103168
RefSeq Peptide - NP_001096638
swissprot - Q1WG82
Ensembl - ENSMUSG00000079681
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zglp1ENSDARG00000067669Danio rerio
 ZGLP1ENSG00000220201Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048599 oocyte development IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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