| MP:0000008 | increased white fat amount | "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnah11b2b1727Clo/Dnah11b2b1727Clo
Genetic Background: C57BL/6J-Dnah11b2b1727Clo
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| MP:0000015 | abnormal ear pigmentation | "anomaly in the coloration of the ear" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh/Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000019 | thick ears | "increased width of the epidermal and cartilaginous tissue that makes up the ear" [J:65045] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0000029 | abnormal malleus morphology | "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0000031 | abnormal cochlea morphology | "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
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| MP:0000039 | abnormal otic capsule morphology | "malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000042 | abnormal organ of Corti | "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0000061 | fragile skeleton | "easily damaged or broken bones" [J:14208] |
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6
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| MP:0000062 | increased bone density | "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Gt(ROSA)26Sortm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Gt(ROSA)26Sortm3(Gli3)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * CBA * SJL/J * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
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| MP:0000065 | abnormal bone marrow cavities | "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Grxcr1pi-3J/Grxcr1pi-3J
Genetic Background: BKS(Cg)-Grxcr1pi-3J/J
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptortm1Rueg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0000071 | axial skeleton hypoplasia | "reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0000087 | absent mandible | "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm3Kba,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000097 | short maxilla | "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0000107 | abnormal frontal bone morphology | "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0000109 | abnormal parietal bone morphology | "malformed curved bone forming part of the vault of the cranium" [J:17489] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0000133 | abnormal long bone metaphysis morphology | "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
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| MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000164 | abnormal cartilage development | "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
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| MP:0000165 | abnormal hypertrophic chondrocyte zone | "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0000166 | abnormal chondrocyte morphology | "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0000172 | abnormal bone marrow cell number | "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000183 | decreased circulating LDL cholesterol level | "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0000188 | abnormal circulating glucose level | "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm2
Genetic Background: either: NOD/LtJ X (NOD/LtJ x CAST/Ei)F1 or SKH2/J X (SKH2/J x CAST/Ei)F1
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| MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
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| MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Xisttm1Awu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
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| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0000222 | decreased neutrophil count | "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Wls/YFP)Mbtr/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0000223 | decreased monocyte count | "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0000229 | abnormal megakaryocyte differentiation | "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000238 | deficiency of pre-B cells | "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
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| MP:0000240 | extramedullary hematopoiesis | "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo
Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Eedtm1Sho/Eedtm1Sho,Eportm1(EGFP/cre)Uk/Epor+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ
Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0000248 | macrocytosis | "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000249 | abnormal blood vessel physiology | "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: En1tm2Alj/En1+,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
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| MP:0000259 | abnormal vascular development | "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509] |
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Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Allelic Composition: Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol,Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB
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| MP:0000272 | abnormal aorta morphology | "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrp6skax26/Lrp6skax26
Genetic Background: involves: C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,S1pr1tm2Rlp/S1pr1tm2Rlp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm6(cre)Bld/Tbx1+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000285 | abnormal cardiac valve morphology | "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia
Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Cdh5-cre)7Mlia/0,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N
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| MP:0000298 | absent endocardial cushion | "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
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| MP:0000301 | reduced size of endocardial cushions | "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
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| MP:0000313 | abnormal cell death | "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0000316 | cellular necrosis | "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Exo1tm3.1Wed/Exo1tm3.1Wed,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000321 | increased bone marrow cell number | "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000322 | increased granulocyte number | "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-Il17a)Awai/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
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| MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Xisttm1Awu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0000334 | decreased granulocyte number | "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0000343 | altered response to myocardial infarction | "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dll3pu/Dll3pu
Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6
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| MP:0000351 | increased cell proliferation | "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2.1(MYC/ERT)Hsc/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Agr2tm1Lex/Agr2tm1Lex,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6
Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J
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| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Zfp830tm2.1Cota/Zfp830tm2.2Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Bcor*A)Vjba/Gt(ROSA)26Sortm1(Bcor*A)Vjba
Genetic Background: Not Specified
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| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ercc1tm1Jhjh/Ercc1tm2Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0000364 | abnormal vascular regression | "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Dll4tm2.1Vlcg/Dll4+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac
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| MP:0000371 | diluted coat color | "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL
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| MP:0000373 | belly spot | "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000400 | abnormal awl hair | "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N
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| MP:0000402 | abnormal zigzag hairs | "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0000405 | abnormal auchene hairs | "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N
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| MP:0000412 | excessive hair | |
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000413 | polyphalangy | "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sortm1.1(DUX4*)Plj
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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| MP:0000418 | patchy hair | "uneven spots of hair growth on the body" [J:26975] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
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| MP:0000420 | ruffled hair | "fuzzy, irregular appearance of the hair" [J:50844] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
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| MP:0000423 | delayed hair regrowth | "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0000424 | retarded hair growth | "slow growth of the hair, appears at normal time" [J:5476] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm5(Wnt5a)Flng/?,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000440 | domed skull | |
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0000445 | short snout | "reduced length of the anterior facial part of the muzzle" [J:53370] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0000455 | abnormal maxilla morphology | "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0000458 | abnormal mandible morphology | "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000462 | abnormal digestive system morphology | "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
Allelic Composition: Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Tfrctm3.1Nca/Tfrctm3.1Nca,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * DBA/2
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| MP:0000465 | gastrointestinal hemorrhage | "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000468 | abnormal esophageal epithelium morphology | "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Jag1Yo/Jag1Yo
Genetic Background: C3HeB/FeJ-Jag1Yo
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: C57BL/6J * SJL/J
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| MP:0000471 | abnormal stomach epithelium morphology | "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb,Tg(KRT14-cre/ERT)20Efu/?
Genetic Background: involves: 129S/SvEv * CD-1
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| MP:0000473 | abnormal stomach glandular epithelium morphology | "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Rad50tm3Jpt/Rad50tm4.1Jpt
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rad50tm1Jpt/Rad50tm3Jpt,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0000479 | abnormal intestinal cell | "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0000480 | increased number of ribs | "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Phc2tm1Hko/Phc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0000484 | abnormal pulmonary artery morphology | "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0000489 | abnormal large intestine morphology | "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5+,Tspan12tm1Wye/Tspan12+
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0000493 | rectal prolapse | "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sortm1.1(DUX4*)Plj
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
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| MP:0000494 | abnormal cecum morphology | "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0000495 | abnormal colon morphology | "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0000516 | abnormal urinary system morphology | "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu/Gt(ROSA)26Sor+,Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
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| MP:0000520 | absent kidney | "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471] |
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Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sor+,Tg(Hoxb7-cre)13Amc/0,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/SvEv * C57BL/6 * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0000528 | delayed kidney development | "late onset of the induction and/or differentiation of the kidney" [J:18048] |
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000530 | abnormal kidney vasculature | "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0000547 | short limbs | "reduced average length of the extremities" [MGI:CLS, J:61509] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(Gli3)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * CBA * SJL/J * Swiss Webster
Allelic Composition: Gli3Xt-J/Gli3Xt-J,Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0000550 | abnormal forelimb morphology | "malformation of the entire anterior extremities" [MGI:tc] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sortm1(Dkk1)Flng,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000551 | absent forelimb | "missing the entire anterior extremities" [MGI:tc, J:54637] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
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| MP:0000556 | abnormal hindlimb morphology | "malformation of the entire posterior extremities" [MGI:tc] |
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0000557 | absent hindlimb | "missing the entire posterior extremities" [MGI:tc, J:54637] |
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Allelic Composition: Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sortm1(Dkk1)Flng,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0000558 | abnormal tibia morphology | "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: chimera involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0000564 | syndactyly | "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
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| MP:0000565 | oligodactyly | "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0,Tg(tetO-Gata6)1Abl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
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| MP:0000571 | interdigital webbing | "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Fgf10tm1.1(cre/ERT2)Sbel/Fgf10tm1.1(cre/ERT2)Sbel
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000572 | abnormal autopod morphology | "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0000574 | abnormal foot pad morphology | "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: C.Cg-Tnfrsf9tm1Byk
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0000575 | dark foot pads | "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0000596 | abnormal liver development | "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Apaf1fog/Apaf1tm1Her
Genetic Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Trp53tm3Tyj/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Col1a1tm5(tetO-Jun/Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0000600 | liver hypoplasia | "reduced size of liver due to decreased cell number " [J:57631] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N
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| MP:0000602 | enlarged sinusoidal spaces | "larger than normal sized cavities in the liver " [J:23170] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0000606 | decreased hepatocyte number | "fewer than normal number of parenchymal liver cells" [J:23170] |
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Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000628 | abnormal mammary gland development | "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB
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| MP:0000630 | mammary gland hyperplasia | "increased size of mammary gland due to increased cell number" [J:63229] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0000635 | pituitary gland hyperplasia | "increased size of pituitary gland due to increased cell number" [J:63229, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0000649 | sebaceous gland atrophy | "wasting or decreased size of holocrine glands of the dermis that secrete sebum into the hair follicles" [J:65146] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0000653 | abnormal sex gland morphology | "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0000659 | prostate gland hyperplasia | "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0000662 | abnormal branching of the mammary ductal tree | "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Trp63tm1Fmc/Trp63tm1Fmc
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0000685 | abnormal immune system morphology | "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: BALB/c * C57BL/6
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| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+,Tg(BCL2)22Wehi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0000693 | spleen hyperplasia | "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0000696 | abnormal Peyer s patches morphology | "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Lcp2tm1Gak/Lcp2tm2Gak,Tg(Pf4-icre)Q3Rsko/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+,Tg(BCL2)22Wehi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0000703 | abnormal thymus morphology | "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0000704 | abnormal thymus development | "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd
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| MP:0000705 | athymia | "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Xisttm1Awu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0000708 | thymus hyperplasia | "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
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| MP:0000709 | enlarged thymus | "increased size of thymus" [J:50053] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0000715 | decreased thymocyte number | "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd
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| MP:0000717 | abnormal lymphocyte number | "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0000729 | abnormal myogenesis | "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf6tm1(cre)Mrc/Myf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pax7tm1.1Fan/Pax7tm2.1(cre/ERT2)Fan
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0000733 | abnormal muscle development | "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Xisttm1Awu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sortm1(DTA)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0000749 | muscle degeneration | "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0000750 | abnormal muscle regeneration | "inability or defects in ability to repair muscle after injuries" [J:42574] |
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Allelic Composition: Pax7tm1.2Fan/Pax7tm1.2Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Pax7tm1(cre/ERT2)Gaka/Pax7+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Tcf7l2tm3.1(cre/ERT2)Mrc/Tcf7l2+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000751 | myopathy | "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574] |
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/Pax7+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Tg(Prrx1-cre/ERT2)1Mlgn/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0000752 | dystrophic muscle | "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994] |
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Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0000754 | partial paralysis | "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
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| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
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| MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000762 | abnormal tongue morphology | "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000764 | abnormal tongue epithelium morphology | "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
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| MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0000785 | telencephalon hypoplasia | "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
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| MP:0000789 | thickened cerebral cortex | "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0000790 | abnormal stratification in cerebral cortex | "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
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| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
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Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc
Allelic Composition: Gt(ROSA)26Sortm1(ACTB-Map2k5*/EGFP)Zxi/Gt(ROSA)26Sortm14(CAG-tdTomato)Hze,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
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| MP:0000822 | abnormal brain ventricle morphology | "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0000832 | abnormal thalamus morphology | "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Olig3tm1(cre)Ynka/Olig3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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| MP:0000841 | abnormal hindbrain morphology | "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N
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| MP:0000848 | abnormal pons | "malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: En1tm3(En2)Alj/En1tm3(En2)Alj,En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster
Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000854 | abnormal cerebellum development | "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm3Kba,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0000857 | abnormal cerebellar foliation | "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951] |
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Allelic Composition: En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm8.1Alj/En1+,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
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| MP:0000859 | abnormal somatosensory cortex morphology | "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0000864 | abnormal vermis | "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000866 | vermis hypoplasia | "reduced cell number in the vermis" [J:61509] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000868 | decreased size of anterior vermis | "smaller appearance of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57538] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0000869 | abnormal posterior vermis | "malformation in the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: En1tm8.1Alj/En1+,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000872 | abnormal external granule cell layer | "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
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| MP:0000873 | thin external granule cell layer | "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic Background: 129S-Wwtr1tm1Benj/J
Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0000874 | irregular external granule cell layer | "uneven thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
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| MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
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| MP:0000877 | abnormal Purkinje cell | "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000880 | decreased Purkinje cell number | "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
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| MP:0000897 | abnormal midbrain | "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Wnt1-cre/ERT)1Alj/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * Swiss Webster
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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| MP:0000904 | abnormal superior colliculus | "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hrba/Hrba
Genetic Background: Not Specified
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| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae *129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic Background: B6.129S-Hesx1tm1(cre)Jpmb
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gnaztm1Lfb/Gnaz+,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
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| MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Msi2tm1.1Cjl/Msi2tm1.1Cjl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0000932 | absent notochord | "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622] |
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Allelic Composition: Gt(ROSA)26Sortm4(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
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| MP:0000933 | abnormal rhombomere morphology | "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?,Tg(Fev-flpe)1Dym/?,Tg(Hoxa2-cre)1Dym/?
Genetic Background: Not Specified
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N
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| MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Lhx2tm1Monu/Lhx2tm1Monu
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
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| MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1+,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
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| MP:0000938 | motor neuron degeneration | "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sor+,Tg(Pgk1-cre)1Lni/0,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
Allelic Composition: Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sortm1(GRN)Pvd,Tg(Pgk1-cre)1Lni/0,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
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| MP:0000939 | reduced motor neuron number | "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Ryr1tm1Slh/Ryr1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Soc/Gt(ROSA)26Sortm1(RARA*)Soc,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(tTA)Roos/?,Lhx3tm1(cre)Slp/Lhx3+,Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Allelic Composition: Gdpd5tm1Itl/Gdpd5tm1.1Itl,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129/Sv * 129X1/SvJ * C57BL/6J
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| MP:0000950 | pharmacologically induced seizures | "seizure activity that is brought about by treatment with pharmacological agents" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0000953 | abnormal oligodendrocyte morphology | "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0000954 | reduced oligodendrocyte progenitor number | "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108] |
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Allelic Composition: Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0000959 | abnormal somatic sensory system morphology | |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia,Hprttm1(CMV-cre)Brd/Hprt+,Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv * 129S/SvEvBrd
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| MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm2Sev/Isl1tm2Sev,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000963 | fused dorsal root ganglia | "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0000966 | reduced sensory neuron number | "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: C57BL/6
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| MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm2Sev/Isl1tm2Sev,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001003 | abnormal olfactory receptor morphology | "anomalous structure of the specialized proteins within the neurons of the olfactory epithelium that normally bind and detect odorants " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Atf5tm1(KOMP)Vlcg/Atf5tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac
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| MP:0001004 | abnormal photoreceptor morphology | "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001006 | abnormal cone morphology | "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Stat5atm2Mam Stat5btm1Mam/Del(11Stat5a-Stat5b)1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
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| MP:0001008 | abnormal sympathetic ganglia morphology | "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0001025 | abnormal sympathetic neuron morphology | "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Egr3tm1Jmi/Egr3tm2.1Wgt,Tg(DBH-cre,-taulacZ)1Wgt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0001034 | abnormal parasympathetic ganglia morphology | "malformation or absence of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Phox2btm3Jbr/Phox2btm3Jbr,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA/J
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| MP:0001045 | abnormal enteric ganglia morphology | "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1+,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
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| MP:0001065 | abnormal trigeminal nerve morphology | "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0001071 | abnormal facial nerve morphology | "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973] |
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Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0001072 | abnormal vestibulocochlear nerve morphology | "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0001076 | abnormal hypoglossal nerve morphology | "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302] |
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001081 | abnormal cranial ganglia morphology | "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302] |
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Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0001082 | abnormal geniculate ganglion morphology | "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0001092 | abnormal trigeminal ganglion morphology | "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038] |
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Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj,Pou4f1tm1Et/Pou4f1tm1Et
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0001093 | small trigeminal ganglion | "reduced size of the trigeminal ganglion" [J:25565, J:17123] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0001096 | abnormal glossopharyngeal ganglion morphology | "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0001100 | abnormal vagus ganglion morphology | "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0001106 | abnormal Schwann cell | "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0001120 | abnormal uterus morphology | "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001126 | abnormal ovary morphology | "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
Allelic Composition: Arid1atm1.1Mag/Arid1a+,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0001127 | small ovary | "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0,Tg(Pomc-EGFP)1Low/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA
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| MP:0001131 | abnormal ovarian follicles | "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
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Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: C57BL/6
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| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Hsp90aa1tm1.1Udon/Hsp90aa1tm1.1Udon
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0001155 | arrest of spermatogenesis | "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271] |
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Allelic Composition: Hsp90aa1tm1.2Udon/Hsp90aa1tm1.2Udon,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N
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| MP:0001158 | abnormal prostate morphology | "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764] |
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Allelic Composition: Psen1tm3.1Shn/Psen1tm3.1Shn,Psen2tm1Haa/Psen2tm1Haa
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gt(ROSA)26Sortm1(JAG1)Xin/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl
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| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0001178 | pulmonary hypoplasia | "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001179 | thicker alveolar septa | |
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Emv30b/Emv30b,Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/?,Mcph1Tg(HLA-A2.1)1Enge/?
Genetic Background: NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs
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| MP:0001182 | lung hemorrhage | "bleeding in the respiratory organs" [J:66345] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
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| MP:0001188 | hyperpigmentation | "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Tyr-cre/ERT2)13Bos
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| MP:0001190 | reddish skin | "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0001191 | abnormal skin condition | "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
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| MP:0001192 | scaly skin | "skin covered with shedding scales or flakes" [J:65146] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N
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| MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
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| MP:0001198 | tight skin | "skin has a taut, stretched appearance" [J:65038] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0001200 | thick skin | "greater depth of skin " [J:47225] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0001211 | wrinkled skin | "irregular folds and/or indentations on the skin" [J:19212] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0001214 | skin hyperplasia | "increased cell number in the skin; usually results in thick skin" [J:47225] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001218 | thin epidermis | "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Slc17a8tm1Edw/Slc17a8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
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| MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
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| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
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| MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0001243 | abnormal dermal layer morphology | "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0001245 | thick dermal layer | "increased depth of the dermis" [J:65033] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
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| MP:0001247 | dermal cysts | "abnormal membranous sacs appearing in the dermis" [J:53379] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Nox4tm1Kkr/Nox4tm1Kkr
Genetic Background: B6.129-Nox4tm1Kkr
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Gt(ROSA)26Sortm1(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl/Gt(ROSA)26Sor+
Genetic Background: B6NTac.Cg-Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(tTA)Roos/?,Lhx3tm1(cre)Slp/Lhx3+,Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(Sall1)Ryn/Gt(ROSA)26Sor+,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Sall1)Ryn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbp+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl/Gt(ROSA)26Sor+
Genetic Background: B6NTac.Cg-Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sortm1.1(DUX4*)Plj
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sortm1(DTA)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gli3Xt-J/Gli3Xt-J,Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Kio/Gt(ROSA)26Sor+,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: B6.129-Tnfrsf4tm2(cre)Nik Gt(ROSA)26Sortm1(DTA)Kio
Allelic Composition: Droshatm1.1Vlcg/Droshatm3Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001270 | distended abdomen | "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atp8a2agil-2J/Atp8a2agil-2J
Genetic Background: AKR/J-Atp8a2agil-2J/J
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
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| MP:0001272 | increased metastatic potential | |
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk,Krastm4Tyj/Krastm4Tyj,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0001273 | decreased metastatic potential | |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0001286 | abnormal eye development | "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Ccr1tm1Cge/Ccr1tm1Cge
Genetic Background: involves: 129S4/SvJae * BALB/c
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| MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0001299 | abnormal eye distance/ position | "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0001304 | cataracts | "complete or partial opacity of the lens" [J:65031] |
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Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0001307 | fused cornea/lens | "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Msx2tm1Rilm/Msx2tm1Rilm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J
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| MP:0001312 | abnormal cornea morphology | "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0001324 | abnormal eye pigmentation | "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001327 | reduced retinal photoreceptor cell number | "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pde6batrd1/Pde6btm1Eye,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
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| MP:0001328 | disorganized retinal layers | "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400] |
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Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001330 | abnormal optic nerve morphology | "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001332 | abnormal optic nerve innervation | "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)60Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001333 | absent optic nerve | "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001340 | abnormal eyelid morphology | "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001341 | absent eyelids | "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J
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| MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
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| MP:0001392 | abnormal locomotor activity | "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ndufs4tm1Rpa/Ndufs4tm1Rpa,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Gt(ROSA)26Sortm47(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm48(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm49(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ndufs4tm1Rpa/Ndufs4tm1Rpa,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm47(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm48(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm49(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm50(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sor+,Tg(Pgk1-cre)1Lni/0,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
Allelic Composition: Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sortm1(GRN)Pvd,Tg(Pgk1-cre)1Lni/0,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
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| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
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| MP:0001415 | increased exploration in new environment | "greater amount of time spent investigating new location" [J:28825] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0001429 | dehydration | "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0001431 | abnormal eating behavior | "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212] |
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Allelic Composition: Gt(ROSA)26Sortm2Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001433 | polyphagia | "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Uga/Gt(ROSA)26Sortm1Uga,Tg(Thy1-cre)703Vaw/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
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| MP:0001491 | unresponsive to tactile stimuli | "absence of reflex action normally induced by touch or pain" [J:43515, J:47439] |
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Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0001504 | abnormal posture | "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
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| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0001510 | abnormal coat appearance | "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0001511 | disheveled coat | "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ndufs4tm1Rpa/Ndufs4tm1Rpa,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
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| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
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| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prkdchanky/Prkdchanky
Genetic Background: either: C57BL/6JAnu or (involves: C57BL/6JAnu * CBA/CaJ)
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0001545 | abnormal hematopoietic system physiology | "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wme/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1(cre/ERT)Nat,Tg(H2-K-BCL2)1Josd/0
Genetic Background: involves: 129 * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0001556 | increased circulating HDL cholesterol level | "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: ArTfm EdaTa-25H/Y
Genetic Background: involves: 101/H * C3H/HeH
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Trp53tm1Brn/Trp53tm1Brn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Lepob/Lepob,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0001570 | abnormal circulating enzyme level | "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0001602 | impaired myelopoiesis | "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
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| MP:0001606 | impaired hematopoiesis | "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+,Tg(tetO-Vegfa)1Kesh/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Fabp4-lacZ)4Mosh/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0001622 | abnormal vasculogenesis | "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
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| MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
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| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
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| MP:0001663 | abnormal digestive system physiology | "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0001664 | abnormal digestion | "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0001666 | abnormal nutrient absorption | "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H
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| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Wnk1tm1Clhu/Wnk1tm1Clhu,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Kdrtm1(cre)Sato/Kdr+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001674 | abnormal triploblastic development | "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
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| MP:0001683 | absent mesoderm | "missing or failure to differentiate the middle primary germ layer " [J:40594] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001685 | abnormal endoderm development | "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Eomestm1Rob/Eomestm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
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| MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0001690 | failure of somite differentiation | "disorganized or absent somite tissue or somite pattern in development" [J:25248] |
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Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah
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| MP:0001693 | failure of primitive streak formation | "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001696 | failure to gastrulate | "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Slc8a1tm2Kdp/Slc8a1tm2Kdp
Genetic Background: involves: 129S4/SvJae * Black Swiss
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL
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| MP:0001700 | abnormal embryo turning | "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0001711 | abnormal placenta | |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001713 | reduced trophoblast cell number | "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171] |
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Allelic Composition: Stat5atm1.1Wjl/Stat5atm1.1Wjl,Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Tsixtm1.1Awu/Y,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Tbx15tm1Apr/Tbx15tm1Apr
Genetic Background: involves: C57BL/6
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001729 | impaired implantation | "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Kio/Gt(ROSA)26Sor+,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: B6.129-Tnfrsf4tm2(cre)Nik Gt(ROSA)26Sortm1(DTA)Kio
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
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| MP:0001762 | polyuria | "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001764 | abnormal homeostasis | "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0001777 | abnormal body temperature regulation | "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
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| MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm3(CAG-Il17a)Awai/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/?,Il5tm1.1(icre)Lky/Il5+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: BALB/c * C57BL/6
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| MP:0001792 | impaired wound healing | "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc
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| MP:0001800 | abnormal humoral immune response | "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cmahtm1Ykoz/Cmahtm1Ykoz
Genetic Background: B6.129P2-Cmahtm1Ykoz
Allelic Composition: Gt(ROSA)26Sortm2.1(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * BALB/cJ
Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0001802 | arrested B cell development | "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607] |
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.129S7(B6)-Rag1tm1Mom
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001805 | decreased IgG | "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0001806 | decreased IgM | "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0001807 | decreased IgA | "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Mirc14tm1.1Czc/Mirc14tm1.1Czc,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd
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| MP:0001824 | abnormal thymic involution | "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Foxn1/ERT2,-GFP)Cbln/Gt(ROSA)26Sor+,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0001825 | arrested T cell development | "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sortm2.1(Mirn150)Rsky
Genetic Background: involves: C57BL/6 * SJL/J
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| MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Card11tm1.1Litt/Card11tm1.1Litt,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0001829 | increased activated T cell number | "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0001844 | autoimmune response | "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0001847 | brain inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001852 | conjunctivitis | "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0001853 | heart inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0001858 | intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001860 | liver inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/0,Tg(Sftpc-Grem1)105Mmyl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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| MP:0001872 | sinus inflammation | "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896] |
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J
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| MP:0001873 | stomach inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001876 | decreased inflammatory response | "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0001879 | abnormal lymphatic vessel morphology | "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Prox1tm4.1Gco/Prox1tm4.1Gco
Genetic Background: involves: 129S1/Sv * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tbx1tm3.1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Lcp2tm1Gak/Lcp2tm2Gak,Tg(Pf4-icre)Q3Rsko/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Lcp2tm1Gak/Lcp2tm2Gak,Tg(Vav1-cre)1Graf/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0001883 | mammary adenocarcinoma | "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: BALB/c * FVB/N
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| MP:0001884 | mammary alveolar hyperplasia | |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0001889 | delayed brain development | "the delay or slower progress of the growth and differentiation of the brain" [J:81818, il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
Allelic Composition: Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL
Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0001919 | abnormal reproductive system physiology | "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl
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| MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001924 | infertility | "inability to produce live offspring" [J:47225] |
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Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen/Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen
Genetic Background: B6.Cg-Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen/J
Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Kmt2btm1Afst/Kmt2btm1.1Afst,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
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| MP:0001927 | abnormal oestrous cycle (sensu Rodentia) | "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
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| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001944 | abnormal pancreas morphology | "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurod1-cre)1Able/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
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| MP:0001947 | abnormal mucociliary clearance | "anomaly in the rate of ciliary and secretory activity of the respiratory submucosal glands" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J
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| MP:0001951 | abnormal breathing | "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ndufs4tm1Rpa/Ndufs4tm1Rpa,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001956 | hypopnea | "breathing that is shallower and/or slower than normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64289] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0001970 | abnormal pain threshold | "increased or decreased average level of perception of pain" [J:17792] |
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Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh
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| MP:0001973 | increased thermal nociceptive threshold | "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194] |
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Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0002007 | increased sensitivity to gamma-irradiation | "increased incidence of cell death following high levels of gamma-irradiation" [J:51834] |
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA
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| MP:0002009 | preneoplasia | "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225] |
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Allelic Composition: Flrt3tm2Kln/Flrt3tm2Kln
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
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| MP:0002014 | papilloma | "benign epithelial tumor" [J:47225] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Allelic Composition: Ptch1tm1Hahn/Ptch1+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Tg(Prrx1-cre/ERT2)1Mlgn/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Bmi1tm1(cre/ERT)Mrc/Bmi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002021 | increased incidence of induced tumors | "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0002023 | B cell derived lymphoma | "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002024 | T cell derived lymphoma | "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2.1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tacc3tm1.1Tno/Tacc3tm1.2Tno,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tacc3tm1.1Tno/Tacc3+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu/Gt(ROSA)26Sor+,Tg(Lck-cre)548Jxm/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu Tg(Lck-cre)548Jxm
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002026 | leukemia | "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2.1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H32Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H27Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * FVB/N
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| MP:0002027 | lung adenocarcinoma | "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Rettm1Cos/Rettm2(RET)Jmi
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002032 | sarcoma | "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CAG-cat-lacZ)11Miya/0,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2
Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002036 | rhabdomyosarcoma | "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0002048 | lung adenoma | "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0002050 | pheochromocytoma | "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
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| MP:0002051 | skin papilloma | "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002058 | neonatal lethality | "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0002060 | abnormal skin morphology | "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Slc17a8tm1Edw/Slc17a8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6NTac
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| MP:0002067 | abnormal sensory capabilities/reflexes/nociception | "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac
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| MP:0002073 | abnormal hair growth | "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
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| MP:0002075 | abnormal coat color | "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh/Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+,Tg(ACTFLPe)9205Dym/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Xisttm1Awu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Bmi1tm1(cre/ERT)Mrc/Bmi1+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tlx3tm1(cre)Qima/Tlx3+
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gli1tm3(cre/ERT2)Alj/Gli1+,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2.1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H32Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H27Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: BALB/c * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Col1a1tm1(tetO-Yap1*)Lrsn/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu/Gt(ROSA)26Sor+,Tg(Lck-cre)548Jxm/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(NOTCH1/GFP)Xhsu Tg(Lck-cre)548Jxm
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
Allelic Composition: Gt(ROSA)26Sortm47(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm48(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm49(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm50(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm51(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Allelic Composition: Ptch1tm1Hahn/Ptch1+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ptch1tm1Hahn/Ptch1+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0,Tg(GFAP-EGFR*,-lacZ)#Agu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Epas1tm1Mcs/Epas1tm1Mcs,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Epas1tm1Mcs
Allelic Composition: Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Col1a1tm5(tetO-Jun/Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sor+,Tg(Pgk1-cre)1Lni/0,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
Allelic Composition: Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sortm1(GRN)Pvd,Tg(Pgk1-cre)1Lni/0,Tg(SOD1*G93A)1Gur/0
Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
Allelic Composition: Bmi1tm1Sgon/Bmi1tm1Sgon,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * FVB/N
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
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| MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0002095 | abnormal skin pigmentation | "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0002102 | abnormal ear morphology | "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Qkqk-v/Qkqk-v,Tg(PGK2-Pacrg)#Jus/?
Genetic Background: involves: BTBR * C57BL/6J * DBA/2
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| MP:0002108 | abnormal muscle morphology | "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pax7tm1(cre/ERT2)Gaka/Pax7+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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| MP:0002109 | abnormal limb morphology | "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Shhtm1Amc/Shhtm2Amc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0002110 | abnormal digit morphology | "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.2Pa,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Shhtm1Amc/Shhtm2Amc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae
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| MP:0002111 | abnormal tail morphology | "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0002114 | abnormal axial skeleton morphology | "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
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| MP:0002115 | abnormal skeleton extremities morphology | "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002116 | abnormal craniofacial bone morphology | "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm3Kba,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL
Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002128 | abnormal blood circulation | "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0002133 | abnormal respiratory system physiology | "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Wt1tm1.1Ceng/Wt1tm1.1Ceng,Tg(tetO-cre)LC1Bjd/0,Tg(NPHS2-rtTA2*M2)1Jbk/0
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0002136 | abnormal kidney physiology | "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu
Allelic Composition: Pkd1tm1Gztn/Pkd1tm1Gztn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
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| MP:0002144 | abnormal B lymphocyte development | "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002145 | abnormal T lymphocyte development | "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Hnrnpltm1.1Tmo/Hnrnpltm1.1Tmo,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Cd4tm1.1Tich/Cd4tm1.1Tich,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Tg(Pax7-cre/ERT2)1Cbm/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm4(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Nap1l2tm2.1Ucr/Nap1l2tm2.1Ucr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Nap1l2tm2.1Ucr/Y,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0002166 | altered tumor susceptibility/resistance | "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)H8Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H32Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H27Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * CD-1)
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sortm2(DTA)Riet
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/?,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1Hjf/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1Hjf/Gt(ROSA)26Sortm1.1Hjf
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Sho/?,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Hjf/?,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sortm1(EYFP)Cos,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1Fia/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(HIF1A/luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hsd11b2tm1(cre)Anft/Hsd11b2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Foxa2tm1.1(rtTa)Moon/Foxa2tm1.1(rtTa)Moon,Gt(ROSA)26Sortm1Sor/?,Tg(tetO-cre)1Jaw/?
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(birA)Mejr/Gt(ROSA)26Sortm1.1(birA)Mejr,Tbx20tm2Ccai/Tbx20tm2Ccai
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu/Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Thy1-cre/ERT2,-EYFP)AGfng/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm3(phiC31*)Sor/Gt(ROSA)26Sortm3(phiC31*)Sor
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm4(attB/attP)Sor/Gt(ROSA)26Sortm4(attB/attP)Sor
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Joe/Gt(ROSA)26Sortm1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm2(icre/ERT2)Jphe
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: En1tm2(cre)Wrst/?,Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?,Tg(Fev-flpe)1Dym/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Egr2tm2(cre)Pch/?,Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?,Tg(Fev-flpe)1Dym/?
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?,Tg(Fev-flpe)1Dym/?,Tg(Hoxa2-cre)1Dym/?
Genetic Background: Not Specified
Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Ggt1-cre)M3Egn/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/?,Tg(Il17f-cre)1Awai/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pbsn*-cre/ERT2)Jir/Hprt+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Plp1-Ncre)DFki/0,Tg(Plp1-Ccre)RFki/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(GFAP-Ccre)FFki/0,Tg(GFAP-Ncre)VFki/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/Gt(ROSA)26Sortm3(SNCA*E46K)Djmo
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sortm1(SNCA*A53T)Djmo
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Blh/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sortm1(SNCA*A53T)Djmo,7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Afst/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm2(CAG-EYFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-EYFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm1.1(CMV-luc,-ALPP)Cklr/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Sall1)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Cdh1tm1.1Mpst/Cdh1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm38.1(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:luc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm39.1(CAG-hop/EYFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm1Sia/Gt(ROSA)26Sortm1Sia
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Maoh/Gt(ROSA)26Sortm1Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-EGFP)Maoh/Gt(ROSA)26Sortm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-mCFP)Maoh/Gt(ROSA)26Sortm3.1(CAG-mCFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4.1(CAG-mCitrine)Maoh/Gt(ROSA)26Sortm4.1(CAG-mCitrine)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm5.1(CAG-mOrange)Maoh/Gt(ROSA)26Sortm5.1(CAG-mOrange)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh/Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet
Genetic Background: involves: BALB/c
Allelic Composition: Tsixtm1.1Awu/Tsixtm1.1Awu,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
Allelic Composition: Tsixtm1.1Awu/Y,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
Allelic Composition: Gt(ROSA)26Sortm1.1Lrsn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm2Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh
Genetic Background: involves: C57BL/6 * NZB
Allelic Composition: Gt(ROSA)26Sortm2Sia/Gt(ROSA)26Sortm2Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm2.1Sia/Gt(ROSA)26Sortm2.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3Sia/Gt(ROSA)26Sortm3Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm3.1Sia/Gt(ROSA)26Sortm3.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm4Sia/Gt(ROSA)26Sortm4Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm4.1Sia/Gt(ROSA)26Sortm4.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm5Sia/Gt(ROSA)26Sortm5Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm5.1Sia/Gt(ROSA)26Sortm5.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm6Sia/Gt(ROSA)26Sortm6Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm6.1Sia/Gt(ROSA)26Sortm6.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm7Sia/Gt(ROSA)26Sortm7Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm7.1Sia/Gt(ROSA)26Sortm7.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm8Sia/Gt(ROSA)26Sortm8Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm8.1Sia/Gt(ROSA)26Sortm8.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm9Sia/Gt(ROSA)26Sortm9Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm9.1Sia/Gt(ROSA)26Sortm9.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm10Sia/Gt(ROSA)26Sortm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm10.1Sia/Gt(ROSA)26Sortm10.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm11Sia/Gt(ROSA)26Sortm11Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm11.1Sia/Gt(ROSA)26Sortm11.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm12Sia/Gt(ROSA)26Sortm12Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sortm12.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm13Sia/Gt(ROSA)26Sortm13Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm13.1Sia/Gt(ROSA)26Sortm13.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm14Sia/Gt(ROSA)26Sortm14Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm14.1Sia/Gt(ROSA)26Sortm14.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm15Sia/Gt(ROSA)26Sortm15Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm15.1Sia/Gt(ROSA)26Sortm15.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm16Sia/Gt(ROSA)26Sortm16Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm16.1Sia/Gt(ROSA)26Sortm16.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm17Sia/Gt(ROSA)26Sortm17Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-EGFP)Npa/Gt(ROSA)26Sor+
Genetic Background: BALB/c-Gt(ROSA)26Sortm2(CAG-EGFP)Npa
Allelic Composition: Gt(ROSA)26Sortm3(CMV-EGFP)Npa/Gt(ROSA)26Sor+
Genetic Background: BALB/c-Gt(ROSA)26Sortm3(CMV-EGFP)Npa
Allelic Composition: Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa/Gt(ROSA)26Sor+
Genetic Background: BALB/c-Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa
Allelic Composition: Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm18.1Sia/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm19.1Sia/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn/Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm1.1Ksvo/Gt(ROSA)26Sortm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg
Genetic Background: involves: 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Meox1tm1(cre)Jpa/Meox1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Genetic Background: B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Allelic Composition: Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Dll4tm3.1Vlcg/Dll4+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Mir128-2tm1.1Ans/Mir128-2tm1.1Ans,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm4(CAG-EGFP*)Nat/Gt(ROSA)26Sortm4(CAG-EGFP*)Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(uprt)Tnr/Gt(ROSA)26Sortm1(uprt)Tnr
Genetic Background: C57BL/6-Gt(ROSA)26Sortm1(uprt)Tnr
Allelic Composition: Gt(ROSA)26Sortm1(CAG-ECFP/EYFP*)Phep/Gt(ROSA)26Sortm1(CAG-ECFP/EYFP*)Phep
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(CAG-ECFP/EYFP*)Phep
Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh
Genetic Background: B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-cas9*,-EGFP)Fezh/Gt(ROSA)26Sortm1.1(CAG-cas9*,-EGFP)Fezh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Embph/Gt(ROSA)26Sortm1Embph
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2.2Ksvo/Gt(ROSA)26Sortm2.2Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm80.1(CAG-COP4*L132C/EYFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-CHRM4*,-mCitrine)Ute/Gt(ROSA)26Sor+
Genetic Background: B6N.129-Gt(ROSA)26Sortm1(CAG-CHRM4*,-mCitrine)Ute/J
Allelic Composition: Gt(ROSA)26Sortm3(CAG-Chrm3*,-mCitrine)Ute/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-tdTomato,-EGFP)Pjen/Gt(ROSA)26Sortm1.1(CAG-tdTomato,-EGFP)Pjen
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1.1(CAG-tdTomato,-EGFP)Pjen
Allelic Composition: Gt(ROSA)26Sortm1.2(CAG-tdTomato,-EGFP)Pjen/Gt(ROSA)26Sortm1.2(CAG-tdTomato,-EGFP)Pjen
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1.2(CAG-tdTomato,-EGFP)Pjen
Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen/Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Tg(Slc26a5-cre)#Jnz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm5(CAG-flpo)Zjh/Gt(ROSA)26Sortm5(CAG-flpo)Zjh
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-tdTomato,-EGFP*)Zjh/Gt(ROSA)26Sortm3(CAG-tdTomato,-EGFP*)Zjh
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-HIST1H2BB/EGFP)Zjh/Gt(ROSA)26Sortm2(CAG-HIST1H2BB/EGFP)Zjh
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir182)Dgk/Gt(ROSA)26Sortm1(CAG-Mir182)Dgk
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl
Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/?,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0002176 | high brain weight | "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rhebtm1.1Pfw/Rhebtm1.1Pfw,Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic Background: involves: C57BL/6
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| MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir21)Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
Allelic Composition: Gt(ROSA)26Sortm2Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
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| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas
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| MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Slc6a4-cre)ET127Gsat/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N
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| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0002191 | abnormal artery morphology | "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
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| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002204 | abnormal neurotransmitter physiology | "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gadd45btm1Flv/Gadd45btm1Flv,Gadd45gtm1Flv/Gadd45gtm1Flv
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(GFP/tetX)Gld/Gt(ROSA)26Sor+,Sim1tm1.1(cre)Gld/Sim1+
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: En1tm2(cre)Gld/En1+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Syngap1tm1.1Geno/Syngap1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
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| MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0002217 | small lymph nodes | "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0002272 | abnormal nervous system electrophysiology | "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Chattm1(cre)Lowl/Chat+,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0002279 | abnormal diaphragm morphology | "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pax3Sp-d/Pax3Sp-d,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * SJL/J
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| MP:0002281 | abnormal respiratory mucosa goblet cell morphology | "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
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| MP:0002344 | abnormal lymph node B cell domain | "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0002347 | abnormal lymph node T cell domain | "anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002357 | abnormal spleen white pulp morphology | "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0002362 | abnormal spleen marginal zone morphology | "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
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| MP:0002367 | abnormal thymus lobule morphology | "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002391 | abnormal Peyer s patch germinal center morphology | "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Runx1tm2.1(cre/Esr1*)Ims/Runx1tm1Medv
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(EYFP)Cos Runx1tm2.1(cre/Esr1*)Ims
Allelic Composition: Bap1tm1.1Geno/Bap1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
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| MP:0002397 | abnormal bone marrow morphology | "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
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| MP:0002398 | abnormal bone marrow cell morphology/development | "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0002404 | intestinal adenoma | "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0002407 | abnormal double-negative T cell | "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002413 | abnormal megakaryoblast morphology/development | "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0002416 | abnormal proerythroblast morphology/development | "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0002417 | abnormal megakaryocyte morphology/development | "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0002427 | dwarfism | "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: 129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
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| MP:0002428 | abnormal semicircular canal | "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0002429 | abnormal blood cell morphology/development | "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0002432 | abnormal CD4+ T cell morphology/development | "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0002435 | abnormal effector T cell morphology/development | "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: involves: BALB/cJ
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| MP:0002441 | abnormal granulocyte morphology/development | "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
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| MP:0002444 | abnormal T cell physiology | "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mlkltm1.2Wsa/Mlkltm1.2Wsa
Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002452 | abnormal antigen presenting cell physiology | "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
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| MP:0002459 | abnormal B cell physiology | "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+,Tg(BCL2)22Wehi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi
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| MP:0002463 | abnormal neutrophil physiology | "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-Il17a)Awai/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0002490 | abnormal circulating immunoglobulin concentration | "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0002492 | decreased IgE | "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
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| MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002495 | increased IgA | "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
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| MP:0002544 | brachydactyly | "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0002590 | increased mean corpuscular volume | "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
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| MP:0002591 | decreased mean corpuscular volume | "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
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| MP:0002599 | increased mean platelet volume | "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0002606 | increased basophil count | "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database] |
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
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| MP:0002608 | increased hematocrit | "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo
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| MP:0002619 | abnormal lymphocyte morphology/development | "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0002631 | abnormal epididymis morphology | "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0002632 | vestigial tail | "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm6(cre)Bld/Tbx1+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0002640 | reticulocytosis | "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0002641 | anisopoikilocytosis | "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002651 | abnormal sciatic nerve | "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0002655 | abnormal keratinocyte morphology | "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0002656 | abnormal keratinocyte differentiation | "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Grk2tm1Gwd/Grk2tm1Gwd,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0002657 | chondrodystrophy | "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0002665 | decreased circulating corticosterone level | "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002675 | asthenozoospermia | "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
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| MP:0002676 | uterine hyperplasia | "increased size of the uterus due to increased cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0002687 | oligozoospermia | "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002693 | abnormal pancreas physiology | "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0002695 | abnormal circulating glucagon level | "anomalous blood concentration of this peptide hormone secreted by the alpha cells of the pancreas; normally leads to a rise in plasma glucose" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0002696 | decreased circulating glucagon level | "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0002699 | abnormal vitreous body | "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0002703 | abnormal renal tubules | "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0002711 | decreased glucagon secretion | "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Sycp1tm1Aps/Sycp1tm1Aps
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002712 | increased circulating glucagon level | "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0002718 | abnormal inner cell mass | "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J
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| MP:0002722 | abnormal immune system organ morphology | "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
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| MP:0002735 | abnormal chemical nociception | "abnormal capability to sense pain elicited by chemical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv
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| MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0002743 | glomerulonephritis | "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002746 | abnormal semilunar valve morphology | "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728] |
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Allelic Composition: Nfatc1tm1.1(cre)Bz/Nfatc1+,Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
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| MP:0002750 | exophthalmos | "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Tyr-cre/ERT2)13Bos
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| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm47(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm48(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm49(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm50(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0002762 | ectopic granule cells | "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978] |
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
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| MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0002765 | short fibula | "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0002768 | small adrenal glands | "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0002780 | decreased circulating testosterone level | "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0002792 | abnormal retinal vascularization | "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,S1pr1tm2Rlp/S1pr1tm2Rlp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+,Tg(Tek-cre)2352Rwng/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
Allelic Composition: Dll4tm2.1Vlcg/Dll4tm2.1Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Egln1tm1Kael/Egln1tm1Kael,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0002796 | impaired skin barrier function | "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0002797 | thigmotaxis | "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814] |
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
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| MP:0002801 | abnormal long-term recognition memory | "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc
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| MP:0002816 | colitis | "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0002825 | abnormal notochord | "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0002840 | abnormal lens fibers morphology | "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB
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| MP:0002841 | impaired skeletal muscle contractility | "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: T/tw73
Genetic Background: involves: M. m. musculus
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| MP:0002855 | abnormal cochlear ganglion morphology | "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0002857 | cochlear ganglion degeneration | "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0002864 | abnormal ocular fundus morphology | "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pde6batrd1/Pde6btm1Eye,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
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| MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+,Tg(NPHS2-icre/ERT2)1Dnsh/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0002872 | polycythemia | "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl
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| MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0002877 | abnormal melanocyte morphology | "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Tyr-cre/ERT2)13Bos
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| MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Uga/Gt(ROSA)26Sortm1Uga,Tg(Thy1-cre)703Vaw/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Red/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0002884 | abnormal branchial arches | "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002886 | abnormal glutamate receptor currents | "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Syngap1tm1.1Geno/Syngap1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
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| MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
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| MP:0002902 | hypophosphaturia | "a reduction of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H
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| MP:0002908 | delayed wound healing | "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
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| MP:0002910 | abnormal excitatory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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| MP:0002926 | aganglionic megacolon | "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0002928 | abnormal bile duct morphology | "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0002929 | abnormal bile duct development | "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0002932 | abnormal joint | "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: C.Cg-Tnfrsf9tm1Byk
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0002938 | white spotting | "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Dysfprmd/Dysfprmd
Genetic Background: A/J
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(OVA/EGFP)Dwir/Gt(ROSA)26Sor+,Tg(TcraTcrb)1100Mjb/0,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002944 | increased lactate dehydrogenase level | "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002945 | abnormal inhibitory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Chattm2(cre)Lowl/Chat+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCr
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| MP:0002947 | hemangioma | "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002950 | abnormal neural crest cell migration | "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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| MP:0002957 | intestinal adenocarcinoma | "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
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| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0002965 | hyperalbuminemia | "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002971 | abnormal brown fat morphology | "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Lepob/Lepob,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0002975 | vascular smooth muscle hypertrophy | "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
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| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0002983 | increased retinal ganglion cell number | "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptf1atm1.1Mgn/Ptf1atm1.1Mgn
Genetic Background: Not Specified
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| MP:0002986 | hypocalciuria | "excretion of abnormally low amounts of calcium in the urine" [J:83000] |
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H
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| MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Spry1tm1.1Jdli/Spry1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0002995 | primary sex reversal | "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxl2tm2.1Tre/Foxl2tm2.1Tre,Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Genetic Background: involves: 129S/Sv * C57BL/6
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| MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0003021 | abnormal coronary flow rate | "aberrant rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Phexm1Jrt/Y
Genetic Background: B6.129S1-PhexM1Jrt
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| MP:0003036 | vertebral transformation | "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Phc2tm1Hko/Phc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0003038 | decreased infarction size | "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
Allelic Composition: Gnai2tm2.1Rneu/Gnai2tm2.1Rneu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(cre/ert2)Tyj Gnai2tm2.1Rneu
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| MP:0003043 | hypoalgesia | "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0003046 | liver cirrhosis | "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0003048 | abnormal cervical vertebrae morphology | "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0003049 | abnormal lumbar vertebrae morphology | "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0003052 | omphalocele | "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003054 | spina bifida | "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Gnaztm1Lfb/Gnaztm1Lfb,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gnaztm1Lfb/Gnaz+,Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003055 | abnormal epiphyseal plate morphology | "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0003056 | abnormal hyoid bone | "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0003057 | abnormal epicardium morphology | "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Achetm1.1Pata/Achetm1.1Pata
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Mir7-1,-EGFP)Horn/Gt(ROSA)26Sor+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0003070 | increased vascular permeability | "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
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| MP:0003071 | decreased vascular permeability | "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
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| MP:0003072 | abnormal metatarsal bone morphology | "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0003076 | increased susceptibility to ischemic brain injury | "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/Gt(ROSA)26Sor+,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Dh/Dh+,Foxn1nu/Foxn1nu
Genetic Background: involves: N:NIH(S)
Allelic Composition: Telo2tm1Tdl/Telo2tm1.1Tdl,Trp53tm1Tyj/Trp53tm1Tyj,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI
Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Ppp1r13ltm1Xlu/Ppp1r13ltm1Xlu
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
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| MP:0003084 | abnormal skeletal muscle fiber morphology | "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf6tm1(cre)Mrc/Myf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0003085 | abnormal egg cylinder morphology | "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0003087 | absent allantois | "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm4(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
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| MP:0003091 | abnormal cell migration | "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0003092 | reduced corneal stroma thickness | "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0003103 | liver degeneration | "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653] |
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Allelic Composition: Dysfprmd/Dysfprmd
Genetic Background: A/J
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| MP:0003109 | short femur | "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0003111 | abnormal nucleus morphology | "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0003119 | abnormal digestive system development | "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss
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| MP:0003124 | hypospadia | "a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0003129 | persistent cloaca | "the presence of a single external opening to which the urinary, digestive and reproductive tracts all connect" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0003130 | anal atresia | "absence of a connection between the anal pit and the rectum" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0003131 | increased erythrocyte count | "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0003135 | increased erythrocyte precursors | "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0003139 | patent ductus arteriosus | "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Itga5tm2Hyn/Itga5tm2Hyn,Itgavtm2Hyn/Itgavtm2Hyn,Tg(H2-K1-tsA58)11Kio/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0003161 | absent lateral semicircular canal | |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
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| MP:0003205 | testicular atrophy | "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hsp90aa1tm1.2Udon/Hsp90aa1tm1.2Udon,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N
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| MP:0003213 | resistance to age related obesity | "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
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| MP:0003222 | increased cardiomyocyte apoptosis | "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(ATF4)Myz/Gt(ROSA)26Sortm2(ATF4)Myz,Tg(Myh11-cre/ERT2)1Soff/?
Genetic Background: either: D2.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff or B6.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff
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| MP:0003223 | decreased cardiomyocyte apoptosis | "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0003229 | abnormal vitelline vasculature | "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257] |
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL
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| MP:0003243 | abnormal dopaminergic neuron morphology | "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo,Tg(Slc6a3-icre)1Fto/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0003244 | loss of dopaminergic neurons | "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0003248 | loss of glutamate neurons | "loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified
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| MP:0003257 | abnormal abdominal wall | "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003270 | intestinal obstruction | "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
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| MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0003288 | intestinal edema | "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Lcp2tm1Gak/Lcp2tm2Gak,Tg(Vav1-cre)1Graf/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0003289 | abnormal intestinal peristalsis | "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003292 | melena | "dark colored, foul-smelling feces due to the presence of blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
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| MP:0003299 | gastric polyps | "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0003304 | large intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0003324 | liver adenoma | "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Trp53tm3Tyj/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
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| MP:0003326 | liver failure | "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003329 | amyloid beta deposits | |
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Allelic Composition: Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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| MP:0003331 | hepatocellular carcinoma | "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Trp53tm3Tyj/Trp53+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0003333 | liver fibrosis | "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003339 | decreased number of pancreatic beta cells | "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Mogtm1(cre)Gkl/?
Genetic Background: involves: C57BL/6
Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
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| MP:0003359 | hypaxial muscle hypoplasia | "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003393 | decreased cardiac output | "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0003396 | abnormal embryonic hematopoiesis | "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
" [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago
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| MP:0003397 | increased muscle weight | "greater than average muscle weight" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0003398 | increased skeletal muscle size | "greater than average dimensions of one or more of the muscles of the skeleton" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0003400 | kinked neural tube | "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0003403 | absent placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417] |
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Allelic Composition: Tsixtm1.1Awu/Y,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0003408 | increased width of hypertrophic chondrocyte zone | "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
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| MP:0003409 | decreased width of hypertrophic chondrocyte zone | "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
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| MP:0003413 | hair follicle degeneration | "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0003414 | epidermal cyst | "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003418 | premature intramembranous bone ossification | "early onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0003424 | premature neuronal precursor differentiation | "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391] |
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Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
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| MP:0003425 | abnormal optic vesicle formation | "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0003446 | renal hypoplasia | "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/SvEv * C57BL/6 * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sor+,Tg(Hoxb7-cre)13Amc/0,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd,Tg(Hoxb7-cre)13Amc/0,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
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| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Sptbm1Jus/Sptbm1Jus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0003448 | altered tumor morphology | "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1+,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003450 | enlarged pancreas | "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003456 | absent tail | "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0003463 | abnormal single cell response | "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission] |
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Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/NJ
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| MP:0003484 | abnormal channel response | "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0003496 | thyroid adenoma | "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac
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| MP:0003531 | abnormal vagina development | "abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
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| MP:0003562 | abnormal beta cell physiology | "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0003567 | abnormal cardiomyocyte proliferation | "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Suz12Plt8/Suz12+
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0003579 | ovarian carcinoma | |
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0003580 | fibroma | "a benign tumor of fibrous or fully developed connective tissue " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003587 | ureter obstruction | "any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu/Gt(ROSA)26Sor+,Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
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| MP:0003596 | epididymal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0003607 | abnormal prostate physiology | "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
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| MP:0003632 | abnormal nervous system morphology | |
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Allelic Composition: Krt71Ca-19J/Krt71+
Genetic Background: BALB/cJ-Krt71Ca-19J/GrsrJ
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sor+,Tg(APPV717F)109Ili/0
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: Gt(ROSA)26Sortm39.1(CAG-hop/EYFP)Hze/Gt(ROSA)26Sor+,Shox2tm1.1(cre)Oki/Shox2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
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| MP:0003635 | abnormal synaptic transmission | "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1Uga/Gt(ROSA)26Sortm1Uga,Tg(Thy1-cre)703Vaw/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Kittm1(cre/ERT2)Dsa/Kit+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
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| MP:0003641 | small lung | "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003643 | spleen atrophy | "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003644 | thymus atrophy | "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0003645 | increased number of pancreatic beta cells | "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Pepddal/Pepddal
Genetic Background: involves: CAST/EiJ * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe/?,Krt19tm1(cre/ERT)Ggu/?
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe Krt19tm1(cre/ERT)Ggu
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| MP:0003647 | absent oligodendrocytes | "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0003648 | abnormal radial glial cell morphology | "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
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| MP:0003649 | reduced right ventricle | |
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Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
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| MP:0003658 | abnormal capillaries | "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0003662 | abnormal proliferative zone | "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
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| MP:0003667 | hemangiosarcoma | "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0003704 | abnormal hair follicle development | "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ilktm1Star/Ilktm1Star,Tg(Krt1-15-cre/PGR)22Cot/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL
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| MP:0003719 | abnormal pericyte morphology | "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
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| MP:0003720 | abnormal neural tube closure | "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099] |
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0003721 | increased tumor growth/size | "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(RAC1*)Jkis/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0003723 | abnormal long bone morphology | "malformation of any of the several elongated bones of the extremities
" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
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| MP:0003725 | increased autoantibody level | "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0003727 | abnormal retinal layer morphology | "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0003733 | abnormal inner nuclear layer morphology | "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003755 | abnormal palate | "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0003760 | short palate | "abnormally decreased length to the roof of the oral cavity" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003763 | abnormal thymus physiology | "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0003787 | abnormal imprinting | "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0003795 | abnormal bone structure | |
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptortm1Rueg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0003798 | abnormal Harderian gland pigmentation | "anomalous coloring of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0003809 | abnormal hair shaft morphology | "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0003814 | vascular smooth muscle cell hypoplasia | "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0003818 | abnormal eye muscle development | "malformation or arrest of differentiation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0003826 | abnormal Mullerian duct morphology | "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0003833 | decreased number of satellite cells | "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pax7tm1(cre/ERT2)Gaka/Pax7+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Tcf7l2tm3.1(cre/ERT2)Mrc/Tcf7l2+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003840 | abnormal coronal suture morphology | "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0003851 | skeletal muscle interstitial fibrosis | "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
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| MP:0003852 | skeletal muscle necrosis | "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0003853 | dry skin | "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N
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| MP:0003865 | lymph node inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0003866 | abnormal defecation | "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sortm1.1(DUX4*)Plj
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
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| MP:0003868 | abnormal feces composition | "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H
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| MP:0003871 | abnormal myelin sheath morphology | "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003873 | branchial arch hypoplasia | "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
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| MP:0003874 | absent branchial arches | "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0003877 | abnormal serotonergic neuron morphology | "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240] |
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0003878 | abnormal ear physiology | "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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| MP:0003883 | enlarged stomach | "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0003884 | decreased macrophage count | "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
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| MP:0003893 | increased hepatocyte proliferation | "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sortm4(HIF2A*)Kael,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0003896 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
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| MP:0003917 | increased kidney weight | "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Allelic Composition: Pkd1tm2Ggg/Pkd1tm2Ggg,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB
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| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0003928 | increased heart rate variability | "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
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| MP:0003934 | abnormal pancreas development | "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1.1(Maml1/EGFP)Hri/?,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0003936 | abnormal reproductive system development | "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0003948 | abnormal gas homeostasis | "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0003949 | abnormal circulating lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0003953 | abnormal hormone level | "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0003960 | increased lean body mass | "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0003964 | abnormal noradrenaline level | "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL
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| MP:0003985 | renal fibrosis | "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0003992 | increased mortality induced by ionizing radiation | "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0003993 | abnormal ventral spinal root morphology | "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA)Roos/?,Lhx3tm1(cre)Slp/Lhx3+,Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
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| MP:0004007 | abnormal lung vasculature | "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
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| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0004021 | abnormal rod electrophysiology | "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0004022 | abnormal cone electrophysiology | "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0004023 | abnormal chromosome number | "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Myc)Rcse/Gt(ROSA)26Sortm1(Myc)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004024 | aneuploidy | "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004025 | polyploidy | "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004029 | spontaneous chromosome breakage | "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
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| MP:0004046 | abnormal mitosis | "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL
Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0004049 | acute promyelocytic leukemia | "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0004057 | thin myocardial compact layer | "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0004073 | caudal body truncation | "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago
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| MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0004090 | abnormal sarcomere morphology | "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0004100 | abnormal spinal cord interneuron morphology | "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: En1tm2(cre)Gld/En1+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ascl1-EGFP,-cre)1Jejo/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * DBA
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| MP:0004101 | abnormal brain interneuron morphology | "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tg(ACTFLPe)9205Dym/0,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lhx6tm2Vpa/Lhx6tm2Vpa,Tg(Nkx2-1-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0004102 | abnormal dorsal striatum morphology | "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004106 | lymphatic vessel hyperplasia | "increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0004111 | abnormal coronary artery morphology | "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Kdrtm1Wag/Kdrtm1Wag,Nfatc1tm1.1(cre)Bz/Nfatc1+,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
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| MP:0004115 | abnormal sinoatrial node morphology | "structural anomaly in the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atruim that is the source of contraction impulses for the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
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| MP:0004121 | abnormal sarcolemma morphology | "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0004129 | abnormal respiratory quotient | "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbp+
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004139 | abnormal parietal cell morphology | "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0004143 | hypertonia | "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004148 | increased cortical bone thickness | "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-RNAi:Hivep3)Glm/Gt(ROSA)26Sor+
Genetic Background: Not Specified
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| MP:0004160 | retroesophageal right subclavian artery | "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004163 | abnormal adenophysis morphology | "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
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| MP:0004165 | abnormal lateral geniculate nucleus morphology | "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Olig3tm1(cre)Ynka/Olig3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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| MP:0004173 | abnormal intervertebral disk morphology | "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
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| MP:0004179 | transmission ratio distortion | "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0004201 | fetal growth retardation | "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004207 | squamous cell carcinoma | "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
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| MP:0004208 | basal cell carcinoma | "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
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| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gli3Xt-J/Gli3Xt-J,Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
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| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0004226 | absent Schlemm s canal | "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0004227 | increased cellular sensitivity to ionizing radiation | "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004229 | abnormal embryonic erythropoiesis | "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0004247 | small pancreas | "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0004256 | abnormal maternal decidual layer morphology | "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004259 | small placenta | "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0004268 | abnormal optic stalk morphology | "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0004272 | abnormal basement membrane morphology | "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220] |
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Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
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| MP:0004274 | abnormal embryonic/fetal subventricular zone morphology | "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0004275 | abnormal postnatal subventricular zone morphology | "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0,Tg(GFAP-EGFR*,-lacZ)#Agu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0004276 | abnormal medial ganglionic eminence morphology | "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Gli2tm2.1Alj/Gli2+,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster
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| MP:0004297 | abnormal proprioceptive neuron morphology | "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
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| MP:0004298 | vestibular ganglion degeneration | "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0004315 | absent saccule | "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004349 | absent femur | "missing the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0004358 | bowed tibia | "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0004362 | cochlear hair cell degeneration | "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
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| MP:0004369 | absent utricle | "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004371 | bowed femur | "increased curvature of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0004376 | absent frontal bone | "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0004377 | small frontal bone | "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0004380 | short frontal bone | "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
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| MP:0004383 | absent interparietal bone | "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0004392 | abnormal CD8-positive T cell physiology | "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004399 | abnormal cochlear outer hair cell morphology | "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0004441 | small occipital bone | "reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0004452 | abnormal pterygoid process morphology | "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004454 | absent pterygoid process | "absence of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004458 | absent alisphenoid bone | "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004460 | alisphenoid bone hypoplasia | "underdevelopment or reduced size in either of the broad curved wing like expanses on each side of the sphenoid bone in adults, usually due to reduced cell number; this bone may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004470 | small nasal bone | "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0004471 | short nasal bone | "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0004473 | absent nasal bone | "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0004481 | abnormal conjunctival epithelium | "any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0004486 | decreased response of heart to induced stress | "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Mliptm1.1(cre)Dzw/Mlip+
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(CAG-CAMK2G*T287D,-EGFP)Whua/Gt(ROSA)26Sor+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
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| MP:0004505 | decreased renal glomerulus number | "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0004506 | abnormal pubic bone morphology | "any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0004509 | abnormal pelvic girdle bone morphology | "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0004515 | abnormal vestibular hair cell stereociliary bundle morphology | "any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
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| MP:0004520 | short vestibular hair cell stereocilia | "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
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| MP:0004523 | decreased cochlear hair cell stereocilia number | "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
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| MP:0004539 | absent maxilla | "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0004562 | abnormal inner hair cell synaptic ribbon morphology | "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0004565 | small myocardial fiber | "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0004609 | vertebral fusion | "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan,Tg(T-cre)1Lwd/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0004610 | small vertebrae | "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
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| MP:0004614 | caudal vertebral transformation | "homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0004615 | cervical vertebral transformation | "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Phc2tm1Hko/Phc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0004616 | lumbar vertebral transformation | "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Phc2tm1Hko/Phc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004618 | thoracic vertebral transformation | "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Phc2tm1Hko/Phc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004620 | cervical vertebral fusion | "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adamts6b2b2182Clo/Adamts6b2b2182Clo
Genetic Background: C57BL/6J-Adamts6b2b2182Clo
Allelic Composition: Gt(ROSA)26Sortm1.1(Phc2*,EGFP)Hko/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004647 | decreased lumbar vertebrae number | "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0004648 | decreased thoracic vertebrae number | "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
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| MP:0004653 | absent caudal vertebrae | "absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0004657 | small sacral vertebrae | "reduced size of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0004672 | short ribs | "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0004701 | decreased circulating insulin-like growth factor I level | "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0004708 | short lumbar vertebrae | "reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0004712 | notochord degeneration | "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0004714 | truncated notochord | "notochord morphology that terminates abruptly as if having an end or point cut off" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0004720 | abnormal platelet morphology | "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004726 | abnormal nasal capsule morphology | "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0004748 | increased susceptibility to age-related hearing loss | "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0004754 | abnormal kidney collecting duct | "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+,Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0004755 | abnormal loop of Henle | "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0004759 | decreased mitotic index | "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0004760 | increased mitotic index | "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG] |
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Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
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| MP:0004762 | increased anti-double stranded DNA antibody level | "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0004768 | abnormal axonal transport | "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0004770 | abnormal synaptic vesicle recycling | "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prnptm2Lnq/Prnptm2Lnq
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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| MP:0004771 | increased anti-single stranded DNA antibody level | "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0004787 | abnormal dorsal aorta morphology | "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
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| MP:0004792 | abnormal synaptic vesicle number | "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0004800 | decreased susceptibility to experimental autoimmune encephalomyelitis | "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2.1(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * BALB/cJ
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0004805 | absent oocytes | "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: C57BL/6
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| MP:0004808 | abnormal hematopoietic stem cell morphology | "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004809 | increased hematopoietic stem cell number | "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004810 | decreased hematopoietic stem cell number | "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Trp53tm1Brn/Trp53tm1Brn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Bmi1tm1Sgon/Bmi1tm1Sgon,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004811 | abnormal neuron physiology | "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc
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| MP:0004815 | abnormal somatic hypermutation frequency | "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac
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| MP:0004816 | abnormal class switch recombination | "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac
Allelic Composition: Atmtm1Shzh/Atmtm2.1Fwa,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004819 | decreased skeletal muscle mass | "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0004831 | long incisors | "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0004841 | abnormal small intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004842 | abnormal large intestine crypts of Lieberkuhn morphology | "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004843 | abnormal Paneth cell morphology | "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
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| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Hsp90aa1tm1.2Udon/Hsp90aa1tm1.2Udon,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004856 | decreased ovary weight | "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
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| MP:0004860 | dilated kidney collecting duct | "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0004880 | lung cysts | |
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004883 | abnormal blood vessel healing | "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0004889 | increased energy expenditure | "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0004890 | decreased energy expenditure | "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0004893 | decreased adiponectin level | "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0004904 | increased uterus weight | "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0004905 | decreased uterus weight | "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0,Tg(Pomc-EGFP)1Low/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA
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| MP:0004922 | abnormal common crus morphology | "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0004929 | decreased epididymis weight | "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0004933 | abnormal epididymis epithelium morphology | "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0004936 | abnormal ureteric bud branching morphogenesis | "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129/SvEv * C57BL/6 * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sor+,Tg(Hoxb7-cre)13Amc/0,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd,Tg(Hoxb7-cre)13Amc/0,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0004938 | dilated vasculature | "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
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| MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ
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| MP:0004941 | abnormal regulatory T cell morphology | "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004946 | abnormal regulatory T cell physiology | "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
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| MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Atoh1tm3Hzo/Atoh1+,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004950 | abnormal brain vasculature | "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S2/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
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| MP:0004952 | increased spleen weight | "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
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| MP:0004953 | decreased spleen weight | "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Bmi1tm1Sgon/Bmi1tm1Sgon,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0004956 | decreased thymus weight | "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004958 | enlarged prostate | "increased size of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
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| MP:0004961 | increased prostate weight | "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0004969 | pale kidney | "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0004972 | abnormal regulatory T cell number | "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0004973 | increased regulatory T cell number | "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0004974 | decreased regulatory T cell number | "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd28tm1Huen/Cd28tm1Huen,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0004978 | decreased B-1 B cell number | "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic Background: BALB/cByJ-Clcn1adr-mto2J
Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sortm2.1(Mirn150)Rsky
Genetic Background: involves: C57BL/6 * SJL/J
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004980 | increased neuronal precursor cell number | "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
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| MP:0004981 | decreased neuronal precursor cell number | "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N
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| MP:0004982 | abnormal osteoclast morphology | "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
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| MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0004988 | increased osteoblast cell number | "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-RNAi:Hivep3)Glm/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptortm1Rueg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0004991 | decreased bone strength | "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
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| MP:0004992 | increased bone resorption | "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
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| MP:0004993 | decreased bone resorption | "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
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| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6
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| MP:0005011 | increased eosinophil count | "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
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| MP:0005012 | decreased eosinophil count | "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gja10tm2(HBEGF/EGFP)Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Il13tm1(YFP/cre)Lky/Il13+,Il4tm1(CD2)Mmrs/Il4+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Epxtm1.1(cre)Jlee/Epx+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005013 | increased lymphocyte number | "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sortm4(Ikbkb)Rsky,Igh-Jtm1Cgn/Ightm4Cgn,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Foxn1/ERT2,-GFP)Cbln/Gt(ROSA)26Sor+,Foxn1tm3(cre)Nrm/Foxn1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sortm2.1(Mirn150)Rsky
Genetic Background: involves: C57BL/6 * SJL/J
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Bmi1tm1Sgon/Bmi1tm1Sgon,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dysfprmd/Dysfprmd
Genetic Background: A/J
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Hes1tm1.1Frad/Hes1tm1.1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0005023 | abnormal wound healing | "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Men1tm1Zqw/Men1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd
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| MP:0005026 | decreased susceptibility to parasitic infection | "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0005027 | increased susceptibility to parasitic infection | "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Il13tm1(YFP/cre)Lky/Il13+,Il4tm1(CD2)Mmrs/Il4+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0005031 | abnormal trophoblast | "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tsixtm1.1Awu/Y,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0005032 | abnormal ectoplacental cone | |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0005033 | abnormal trophoblast cells | "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761] |
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Allelic Composition: Tsixtm1.1Awu/Y,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0005036 | diarrhea | "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0005065 | abnormal neutrophil morphology | "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0005075 | abnormal melanosome morphology | "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0005076 | abnormal cell differentiation | "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sor+,Tg(SFTPC-rtTA)5Jaw/0
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
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| MP:0005087 | reduced acute inflammation | "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
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| MP:0005088 | increased acute inflammation | "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0005089 | decreased double-negative T cell count | "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8
" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
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| MP:0005090 | increased double-negative T cells count | "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005091 | increased double-positive T cell count | "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Mirc14tm1.1Czc/Mirc14tm1.1Czc,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0005093 | impaired B cell proliferation | "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0005100 | abnormal choroid pigmentation | "anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0005103 | abnormal retinal pigmentation | "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0005108 | abnormal ulna morphology | "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0005114 | premature hair loss | "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0005120 | decreased circulating growth hormone level | "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-GCaMP5)Ryba/Gt(ROSA)26Sor+,Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0005152 | pancytopenia | "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450] |
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0005154 | increased B cell proliferation | "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0005159 | azoospermia | "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hsp90aa1tm1.2Udon/Hsp90aa1tm1.2Udon,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N
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| MP:0005164 | abnormal response to injury | "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir21)Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
Allelic Composition: Gt(ROSA)26Sortm2Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
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| MP:0005165 | increased susceptibility to injury | "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir21)Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
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| MP:0005166 | decreased susceptiblity to injury | "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0005167 | abnormal blood-brain barrier | "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
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| MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
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| MP:0005191 | head tilt | "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0005193 | abnormal anterior eye segment morphology | "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0005197 | abnormal uvea morphology | "structural anomaly of the pigmented vascular coat of the eyeball, consisting of the iris, ciliary body, and choroid " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0005201 | abnormal retinal pigment epithelium morphology | "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005205 | abnormal eye anterior chamber | "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurod1-cre)1Able/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hprttm1(Ins2-HBEGF)Herr/Y,Tg(Ins2-cre/ERT)1Dam/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0005216 | abnormal pancreatic alpha cell morphology | "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0005217 | abnormal pancreatic beta cell morphology | "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005220 | abnormal exocrine pancreas morphology | "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005221 | abnormal rostral-caudal axis patterning | "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005238 | increased brain size | "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0005240 | abnormal amacrine cell morphology | "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0005241 | abnormal retinal ganglion layer morphology | "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
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| MP:0005244 | hemopericardium | "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129
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| MP:0005253 | abnormal eye physiology | "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0005257 | abnormal intraocular pressure | "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0005262 | coloboma | "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0005277 | abnormal brainstem morphology | "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670] |
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0005280 | abnormal fatty acid level | "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Hprttm6(CAG-Fat1)Geno/Hprttm6(CAG-Fat1)Geno
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0005288 | abnormal oxygen consumption | "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Cvw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/NJ
Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0005297 | spina bifida occulta | "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0005307 | head tossing | "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0005310 | abnormal salivary gland physiology | "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0005317 | increased triglyceride level | "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0005318 | decreased triglyceride level | "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
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| MP:0005319 | abnormal enzyme/ coenzyme level | "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0005322 | abnormal serotonin level | "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo,7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0005324 | ascites | "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
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| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: ArTfm EdaTa-25H/Y
Genetic Background: involves: 101/H * C3H/HeH
Allelic Composition: Gt(ROSA)26Sortm3(H1/tetO-RNAi:Mir143)Jcbr/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
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| MP:0005343 | increased circulating aspartate transaminase level | "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
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Allelic Composition: Dysfprmd/Dysfprmd
Genetic Background: A/J
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005348 | increased T cell proliferation | "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
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| MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0005403 | abnormal nerve conduction | "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
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| MP:0005405 | axon degeneration | "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0005418 | abnormal circulating hormone level | "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0005422 | osteosclerosis | "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0005430 | absent fibula | "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok,Tg(Hoxb6-cre/ERT)1Smac/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0005449 | abnormal food intake | "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0005450 | abnormal energy expenditure | "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0005459 | decreased percent body fat | "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
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| MP:0005463 | abnormal CD4+ T cell physiology | "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005465 | abnormal T helper 1 physiology | "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0005466 | abnormal T helper 2 physiology | "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions
" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J
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| MP:0005477 | increased circulating thyroxine level | "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
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| MP:0005478 | decreased circulating thyroxine level | "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0005480 | increased circulating triiodothyronine level | "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
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| MP:0005481 | chronic myelocytic leukemia | "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
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| MP:0005488 | bronchial epithelial hyperplasia | "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rettm1Cos/Rettm2(RET)Jmi
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
Genetic Background: involves: 129S6/SvEv * C57BL/6
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| MP:0005493 | stomach epithelial hyperplasia | |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005503 | abnormal tendon morphology | "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509] |
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Allelic Composition: Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: C.Cg-Tnfrsf9tm1Byk
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
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| MP:0005505 | increased platelet count | "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0005535 | abnormal body temperature | "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh
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| MP:0005542 | corneal vascularization | "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0005543 | corneal thinning | "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0005546 | choroidal neovascularization | "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh/Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005547 | abnormal Muller cell morphology | "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0005548 | retinal pigment epithelium atrophy | "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cpoxnct/Cpoxnct
Genetic Background: Not Specified
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| MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Venus,-Sdk2)Jrs/Gt(ROSA)26Sor+,Sdk2tm1.1(cre/ERT2)Jrs/Sdk2tm1.1(cre/ERT2)Jrs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
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| MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0005561 | increased mean corpuscular hemoglobin | "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
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| MP:0005562 | decreased mean corpuscular hemoglobin | "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
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| MP:0005564 | increased hemoglobin content | "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0005575 | increased pulmonary ventilation | "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
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| MP:0005585 | increased tidal volume | "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0005592 | abnormal vascular smooth muscle morphology | "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+,Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/Gt(ROSA)26Sor+,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S2/SvEv * 129S6/SvEvTac * C57BL/6 * SJL
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| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: T/tw73
Genetic Background: involves: M. m. musculus
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0005601 | increased angiogenesis | "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Kdrtm1Jrt/Kdr+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6NCr * CD-1
Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
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| MP:0005602 | decreased angiogenesis | "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0005603 | neuron hypertrophy | "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0005605 | increased bone mass | "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Kdrtm1Wag/Kdrtm1Wag,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(tetO-RNAi:Hivep3)Glm/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0005606 | increased bleeding time | "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sor/Gt(ROSA)26Sor,Igs4tm1Hsas/Igs4tm1Hsas
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd
Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Zfp809tm1c(KOMP)Wtsi/Zfp809tm1c(KOMP)Wtsi,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005643 | decreased dopamine level | "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298] |
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo,7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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| MP:0005650 | abnormal limb bud morphology | "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005658 | susceptibility to diet-induced obesity | "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0005659 | resistance to diet-induced obesity | "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Grm5tm1Fcq/Grm5tm1Fcq
Genetic Background: Not Specified
Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0005661 | decreased circulating adrenaline level | "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0005664 | decreased circulating noradrenaline level | "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0005665 | increased circulating noradrenaline level | "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo,7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic Background: involves: 129 * C57BL/6
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| MP:0005668 | decreased circulating leptin level | "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0005670 | abnormal white fat physiology | "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
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| MP:0006000 | abnormal corneal epithelium | "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0006001 | abnormal intestinal transit time | "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator] |
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006007 | abnormal basal ganglion morphology | "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0006011 | abnormal endolymphatic duct morphology | "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0006020 | reduced size of tympanic ring | "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006027 | impaired alveologenesis | "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546] |
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: T/tw73
Genetic Background: involves: M. m. musculus
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: T/tw73
Genetic Background: involves: M. m. musculus
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0006038 | increased mitochondrial proliferation | "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1.1(MYC/ERT2)Gev
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Aurkatm1.1Tvd/Aurkatm1.1Tvd,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0006043 | decreased apoptosis | "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ay/Ay
Genetic Background: 101-Ay
Allelic Composition: Trp53tm4Att/Trp53tm4Att,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
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| MP:0006050 | pulmonary fibrosis | "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/0,Tg(Sftpc-Grem1)105Mmyl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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| MP:0006055 | abnormal vascular endothelial cell morphology | "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0006056 | increased vascular endothelial cell number | "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+,Tg(tetO-Vegfa)1Kesh/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
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| MP:0006058 | decreased cerebral infarction size | "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Relatm2.1Gho/Relatm2.1Gho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0006069 | abnormal retinal neuronal layer morphology | "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3] |
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA
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| MP:0006082 | CNS inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request] |
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Allelic Composition: Gt(ROSA)26Sortm1(HA)Libl/Gt(ROSA)26Sortm1(HA)Libl,Mogtm1(cre)Gkl/?,Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0006089 | abnormal saccule morphology | "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0006093 | arteriovenous malformation | "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125] |
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0006095 | absent amacrine cells | "absence or loss of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:74753] |
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA
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| MP:0006104 | abnormal tectum morphology | "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762] |
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Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm,Tg(Tek-cre)1Ywa/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm,H2afvTg(Wnt1-cre)11Rth/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0006149 | blurred vision | "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0006207 | embryonic lethality during organogenesis | "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Kdrtm1(cre)Sato/Kdr+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd
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| MP:0006208 | embryonic lethality throughout fetal growth and development | "death anytime after the completion of organogenesis but before E18.5 (E14 to less than E18.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Wt1-cre)#Jbeb/0
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0006243 | abnormal pupil dilation reaction to light | "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tgm2tm1Gml/Tgm2tm1Gml
Genetic Background: involves: C57BL/6 * DBA/1LacJ
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| MP:0006271 | abnormal involution of the mammary gland | "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0006279 | abnormal limb development | "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0006281 | abnormal tail development | "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0006282 | abnormal posterior horn morphology | "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv
Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor
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| MP:0006283 | medulloblastoma | "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tlx3tm1(cre)Qima/Tlx3+
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gli1tm3(cre/ERT2)Alj/Gli1+,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0006292 | abnormal olfactory placode morphology | "any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0006298 | abnormal platelet activation | "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lcp2tm1Gak/Lcp2tm2Gak,Tg(Pf4-icre)Q3Rsko/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006301 | abnormal mesenchyme morphology | "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0006303 | abnormal retinal nerve fiber layer morphology | "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)251Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla,Tg(Crx-Atoh7,-cre)60Gla/0,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0006309 | decreased retinal ganglion cell number | "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6
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| MP:0006321 | increased myocardial fiber number | "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0006322 | abnormal perichondrium morphology | "any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0006334 | abnormal susceptibility to hearing loss | "anomaly in the sensitivity to loss of hearing related to age or environmental factors " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0006346 | small branchial arch | "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0006359 | absent startle reflex | "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0006362 | abnormal male germ cell morphology | "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ano1tm1.1Jwo/Ano1tm1.1Jwo,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0006380 | abnormal spermatid morphology | "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0006396 | decreased long bone epiphyseal plate size | "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
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| MP:0006397 | disorganized long bone epiphyseal plate | "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0006408 | dorsal root ganglion hypoplasia | "underdevelopment or reduced size, usually due to a reduced cell number, of a dorsal root ganglion or ganglia" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm2Sev/Isl1tm2Sev,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Mcl1tm1Ywh/Mcl1tm1Ywh
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0006414 | decreased T cell apoptosis | "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
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| MP:0008000 | ovary tumor | "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0008008 | early cellular replicative senescence | "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dh/Dh+,Foxn1nu/Foxn1nu
Genetic Background: involves: N:NIH(S)
Allelic Composition: Zfp830tm2.1Cota/Zfp830tm2.2Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Ppp1r13ltm1Xlu/Ppp1r13ltm1Xlu
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0008011 | intestinal polyps | "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
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| MP:0008014 | lung tumor | "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ltbp1tm2Veto/Ltbp1tm2Veto
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm3(CAG-luc)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev,Krastm4Tyj/Krastm4Tyj
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008019 | liver tumor | "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
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| MP:0008021 | blastoma | "a fast growing and invasive tumor composed chiefly or entirely of immature undifferentiated cells that have embryonic characteristics resembling the primordium of the organ in which the tumor arose" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
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| MP:0008026 | abnormal brain white matter morphology | "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0008029 | abnormal paraxial mesoderm | "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0008031 | decreased Cajal-Retzius cell number | "reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Trp73tm1(cre)Agof/Trp73+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Trp73tm1(cre)Agof/Trp73+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Wnt3atm1(cre)Eag/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Trp73tm1(cre)Agof/Trp73+,Wnt3atm1(cre)Eag/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0008037 | abnormal T cell morphology | "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0008040 | decreased NK T cell number | "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008042 | abnormal NK T cell physiology | "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Sh2d1atm1.1Knic/Sh2d1atm1.1Knic,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Allelic Composition: Sh2d1atm1.1Knic/Y,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
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| MP:0008045 | decreased NK cell number | "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"] |
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Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0008051 | abnormal memory T cell physiology | "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will
Genetic Background: Not Specified
Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0008053 | abnormal NK cell differentiation | "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0008056 | abnormal retinal ganglion cell morphology | "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+,Ngfrtm1Klee/Ngfrtm1Klee,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv
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| MP:0008058 | abnormal DNA repair | "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Telo2tm1Tdl/Telo2tm1.1Tdl,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J
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| MP:0008059 | abnormal podocyte foot process morphology | "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+,Tg(NPHS2-icre/ERT2)1Dnsh/0
Genetic Background: involves: C57BL/6
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| MP:0008060 | abnormal podocyte slit diaphragm morphology | "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0008071 | absent B cells | "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nalcnem1Iiis/Nalcn+
Genetic Background: Not Specified
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| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic Background: BALB/cByJ-Clcn1adr-mto2J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0008076 | abnormal CD4-positive T cell differentiation | "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Cd4tm1.1Tich/Cd4+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Stat5atm2Mam Stat5btm1Mam/Del(11Stat5a-Stat5b)1Mam,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
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| MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic Background: BALB/cByJ-Clcn1adr-mto2J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Lef1tm1Hhx/Lef1tm1Hhx,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0008080 | abnormal CD8-positive T cell differentiation | "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0008082 | increased single-positive T cell number | "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008083 | decreased single-positive T cell number | "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008086 | increased T-helper 1 cell number | "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149] |
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008088 | abnormal T-helper 1 cell differentiation | "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0008094 | absent memory B cells | "absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008097 | increased plasma cell number | "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008098 | decreased plasma cell number | "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
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| MP:0008099 | abnormal plasma cell differentiation | "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+,Tg(BCL2)22Wehi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0008101 | lymph node hypoplasia | "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
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| MP:0008102 | lymph node hyperplasia | "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Allelic Composition: Pi4katm2.1Arte/Pi4katm2.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0008111 | abnormal granulocyte differentiaton | "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0008112 | abnormal monocyte differentiation | "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0008115 | abnormal dendritic cell differentiation | "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0008124 | decreased plasmacytoid dendritic cell number | "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797] |
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0008127 | decreased dendritic cell number | "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0008133 | decreased Peyer s patch number | "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008135 | small Peyer s patches | "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+,Tg(NPHS2-icre/ERT2)1Dnsh/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0008142 | decreased small intestinal villus size | "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0008143 | abnormal dendrite morphology | "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(ACTB-Map2k5*/EGFP)Zxi/Gt(ROSA)26Sortm14(CAG-tdTomato)Hze,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
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| MP:0008146 | asymmetric rib-sternum attachment | "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008152 | decreased diameter of femur | "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0008156 | decreased diameter of tibia | "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0008158 | increased diameter of femur | "increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0008162 | increased diameter of tibia | "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0008166 | abnormal B-2 B cell morphology | "any structual anomaly of a conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008167 | increased B-1a cell number | "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604] |
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0008168 | decreased B-1a cell number | "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604] |
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Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008172 | abnormal follicular B cell morphology | "any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008173 | increased follicular B cell number | "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
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| MP:0008174 | decreased follicular B cell number | "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
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| MP:0008177 | increased germinal center B cell number | "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Cmahtm1Ykoz/Cmahtm1Ykoz
Genetic Background: B6.129P2-Cmahtm1Ykoz
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0008178 | decreased germinal center B cell number | "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008179 | absent germinal center B cells | "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008181 | increased marginal zone B cell number | "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0008182 | decreased marginal zone B cell number | "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1
Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0008183 | absent marginal zone B cells | "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008185 | decreased naive B cell number | "reduced number of mature B cells which have not yet been activated by antigen" [CL:0000788, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008186 | increased pro-B cell number | "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008190 | decreased transitional stage B cell number | "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008192 | abnormal germinal center B cell physiology | "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Sh2d1atm2.1Cpt/Y,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Sh2d1atm2.1Cpt/Sh2d1atm2.1Cpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0008193 | abnormal marginal zone B cell physiology | "abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
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| MP:0008207 | decreased B-2 cell number | "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604] |
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Allelic Composition: Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic Background: BALB/cByJ-Clcn1adr-mto2J
Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sortm2.1(Mirn150)Rsky
Genetic Background: involves: C57BL/6 * SJL/J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
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| MP:0008208 | decreased pro-B cell number | "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008210 | increased mature B cell number | "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008211 | decreased mature B cell number | "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic Background: BALB/cByJ-Clcn1adr-mto2J
Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * SJL/J
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky,Igh-Jtm1Cgn/Ightm4Cgn,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky,Igh-Jtm1Cgn/Ightm4Cgn,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008212 | absent mature B cells | "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008213 | absent immature B cells | "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008215 | decreased immature B cell number | "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu,Xisttm1Awu/Y
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ptch1tm1Hahn/Ptch1tm1Hahn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008217 | abnormal B cell activation | "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008235 | increased susceptibility to neuronal excitotoxicity | "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6
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| MP:0008236 | decreased susceptibility to neuronal excitotoxicity | "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw/Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0008246 | abnormal leukocyte morphology | "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637] |
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008249 | abnormal common lymphocyte progenitor cell morphology | "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577] |
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0008250 | abnormal myeloid leukocyte morphology | "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
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| MP:0008254 | increased megakaryocyte cell number | "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0008255 | decreased megakaryocyte cell number | "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Fnip1m1Btlr/Fnip1m1Btlr,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(Eif1a-tTA,tetO-mCherry/HTR4*D100A)Conk/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008273 | abnormal intramembranous bone ossification | "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0008275 | failure of endochondral bone ossification | "failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958] |
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hsp90aa1tm1.2Udon/Hsp90aa1tm1.2Udon,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0008301 | adrenal medulla hyperplasia | "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0008321 | small adenohypophysis | "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Par/Nf1tm1Par,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0008329 | decreased somatotroph cell number | "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0008335 | decreased gonadotroph cell number | "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
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| MP:0008341 | decreased corticotroph cell number | "reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Foxo1*)Jcbr/Gt(ROSA)26Sor+,Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0008346 | increased gamma-delta T cell number | "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149] |
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0008347 | decreased gamma-delta T cell number | "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149] |
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0008348 | absent gamma-delta T cells | "absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149] |
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0008372 | small malleus | "reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0008376 | small manubrium | "reduced size of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0008388 | hypochromic microcytic anemia | "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0008392 | decreased primordial germ cell number | "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
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| MP:0008395 | abnormal osteoblast differentiation | "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008414 | abnormal spatial reference memory | "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc
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| MP:0008432 | abnormal long-term spatial reference memory | "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc
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| MP:0008439 | abnormal cortical plate morphology | "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0008449 | abnormal retinal cone cell outer segment morphology | "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pde6batrd1/Pde6btm1Eye,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
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| MP:0008457 | abnormal cortical intermediate zone morphology | "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0008462 | abnormal medium spiny neuron morphology | "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319] |
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Allelic Composition: Gt(ROSA)26Sortm48(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
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| MP:0008470 | abnormal spleen B cell follicle morphology | "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0008474 | absent spleen germinal center | "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
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| MP:0008475 | intermingled spleen red and white pulp | "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008476 | increased spleen red pulp amount | "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008477 | decreased spleen red pulp amount | "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0008478 | increased spleen white pulp amount | "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
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| MP:0008479 | decreased spleen white pulp amount | "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0008482 | decreased spleen germinal center number | "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
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| MP:0008484 | decreased spleen germinal center size | "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Ncoa6tm3Jxu/Ncoa6tm3Jxu,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Bmi1tm1(cre/ERT)Mrc/Bmi1+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0008495 | decreased IgG1 level | "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008496 | decreased IgG2a level | "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
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| MP:0008497 | decreased IgG2b level | "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008498 | decreased IgG3 level | "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008500 | increased IgG2a level | "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0008501 | increased IgG2b level | "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0008502 | increased IgG3 level | "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0008507 | thin retinal ganglion layer | "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0008511 | thin retinal inner nuclear layer | "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0008514 | absent retinal inner plexiform layer | "absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0008515 | thin retinal outer nuclear layer | "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0008518 | retinal outer nuclear layer degeneration | "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008528 | polycystic kidney | "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pkd1tm1Gztn/Pkd1tm1Gztn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0008532 | decreased chemical nociceptive threshold | "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm2Sev/Isl1tm2Sev,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
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| MP:0008539 | decreased susceptibility to induced colitis | "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-CAMK2G*T287D,-EGFP)Whua/Gt(ROSA)26Sor+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0008546 | abnormal vesicle-mediated transport | "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192] |
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Allelic Composition: Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H
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| MP:0008547 | abnormal neocortex morphology | "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0008559 | abnormal interferon-gamma secretion | "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Lef1tm1Hhx/Lef1tm1Hhx,Tcf7tm1Cle/Tcf7tm1Cle,Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Tg(GZMB-cre)1Jcb/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Sh2d1atm1.1Knic/Sh2d1atm1.1Knic,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Allelic Composition: Sh2d1atm1.1Knic/Y,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
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| MP:0008577 | increased circulating interferon-gamma level | "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0008586 | disorganized photoreceptor outer segment | "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0008588 | abnormal circulating interleukin level | "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0008593 | increased circulating interleukin-10 level | "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0008597 | decreased circulating interleukin-6 level | "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
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| MP:0008599 | increased circulating interleukin-2 level | "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008602 | increased circulating interleukin-4 level | "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008603 | decreased circulating interleukin-4 level | "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Sh2d1atm1.1Knic/Sh2d1atm1.1Knic,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Allelic Composition: Sh2d1atm1.1Knic/Y,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
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| MP:0008614 | increased circulating interleukin-17 level | "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-Il17a)Awai/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008638 | increased circulating interleukin-1 alpha level | "increase in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300] |
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Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
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| MP:0008641 | increased circulating interleukin-1 beta level | "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0008660 | increased interleukin-10 secretion | "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008672 | increased interleukin-13 secretion | "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
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| MP:0008673 | decreased interleukin-13 secretion | "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-Il17a)Awai/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008687 | increased interleukin-2 secretion | "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008688 | decreased interleukin-2 secretion | "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Plcg1tm1Gcrp/Plcg1tm1Rwen,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
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| MP:0008702 | increased interleukin-5 secretion | "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac
Allelic Composition: P2ry6tm1Jabo/P2ry6tm1Jabo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte P2ry6tm1Jabo
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| MP:0008703 | decreased interleukin-5 secretion | "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008714 | lung carcinoma | "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
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| MP:0008728 | increased memory B cell number | "greater number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008729 | decreased memory B cell number | "reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
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| MP:0008730 | fused phalanges | "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0008750 | abnormal interferon level | "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440] |
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Allelic Composition: Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0008754 | abnormal T cell receptor V(D)J recombination | "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008758 | abnormal T cell receptor beta chain V(D)J recombination | "any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6
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| MP:0008762 | embryonic lethality | "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Gt(ROSA)26Sortm6(Vegfa*)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Gt(ROSA)26Sortm10(Gata2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Allelic Composition: Gt(ROSA)26Sortm5(Wnt5a)Flng/?,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0008778 | lymphangiogenesis | "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500] |
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Syktm1.1(cre)Fkfr/Syktm1.1(cre)Fkfr,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008782 | increased B cell apoptosis | "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Clcn1adr-mto2J/Clcn1adr-mto2J
Genetic Background: BALB/cByJ-Clcn1adr-mto2J
Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sortm2.1(Mirn150)Rsky
Genetic Background: involves: C57BL/6 * SJL/J
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008783 | decreased B cell apoptosis | "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008786 | abnormal hindgut morphology | "any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0008788 | abnormal fetal cardiomyocyte morphology | "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040] |
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Allelic Composition: Suz12Plt8/Suz12+
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0008800 | increased small intestinal crypt cell apoptosis | "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0008806 | increased circulating amylase level | "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0008807 | increased liver iron level | "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re
Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
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| MP:0008809 | increased spleen iron level | "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
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| MP:0008810 | increased circulating iron level | "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re
Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
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| MP:0008813 | decreased common myeloid progenitor cell number | "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0008818 | abnormal interfrontal bone morphology | "any structural anomaly or presence of a bone between the frontal bones in the skull; an extra bony plate within the anterior fontanelle that is not usually present" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0008825 | abnormal cardiac epithelial to mesenchymal transition | "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760] |
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Allelic Composition: Jag1tm1Frad/Jag1tm1Frad,Tg(Cdh5-cre)7Mlia/0
Genetic Background: B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia
Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Cdh5-cre)7Mlia/0,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N
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| MP:0008826 | abnormal splenic cell ratio | "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0008828 | abnormal lymph node cell ratio | "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008829 | triphalangia | "malformation in which three phalanges are present in the thumb or great toe" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
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| MP:0008842 | lipofuscinosis | "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
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| MP:0008847 | abnormal suprachiasmatic nucleus morphology | "any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.317.357.342.625] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6
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| MP:0008852 | retinal neovascularization | "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0008858 | abnormal hair cycle anagen phase | "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0008859 | abnormal hair cycle catagen phase | "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0008860 | abnormal hair cycle telogen phase | "anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and preceeds hair loss" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: Gt(ROSA)26Sortm1(Myc)Rcse/Gt(ROSA)26Sortm1(Myc)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Atmtm1Shzh/Atmtm2.1Fwa,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac
Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0008868 | abnormal granulosa cell morphology | "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: C57BL/6
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| MP:0008872 | abnormal response to xenobiotics | "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Asic3tm1Wsh/Asic3tm1Wsh
Genetic Background: B6.129-Asic3tm1Wsh
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| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H
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| MP:0008877 | abnormal DNA methylation | "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306] |
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Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0008883 | abnormal enterocyte proliferation | "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0008884 | abnormal enterocyte apoptosis | "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0008885 | increased enterocyte apoptosis | "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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| MP:0008901 | absent epididymal fat pad | "absence of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0008916 | abnormal astrocyte physiology | "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mir21)Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
Allelic Composition: Gt(ROSA)26Sortm2Jake/Gt(ROSA)26Sor+,Tg(Gfap-cre)#Mvs/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd
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| MP:0008917 | abnormal oligodendrocyte physiology | "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600] |
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0008935 | decreased mean platelet volume | "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0008941 | reticulocytopenia | "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0008947 | increased neuron number | "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn/Gt(ROSA)26Sortm1(CAG-Bgeo,-Insc/GFP)Jakn,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6
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| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Resttm1.1Jhsi/Resttm1.1Jhsi,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6N
Allelic Composition: Wnt1tm1.1Mze/Wnt1tm1.1Mze,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Tg(Pomc-EGFP)1Low/0,Tg(Gnrh1-cre)1Dlc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0008963 | increased carbon dioxide production | "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0008973 | decreased erythroid progenitor cell number | "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0009004 | progressive hair loss | "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009011 | prolonged diestrus | "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
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| MP:0009017 | prolonged estrus | "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
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| MP:0009023 | abnormal spinal cord meninges morphology | "any structural anomaly in any of the membranes covering the spinal cord, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0009049 | abnormal hallux morphology | "any structural anomaly of the first or primary digit of the foot" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J
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| MP:0009050 | dilated proximal convoluted tubules | "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0009052 | anal stenosis | "abnormal narrowing or constriction of the anal orifice" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0009092 | endometrium hyperplasia | "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0009093 | oocyte degeneration | "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: C57BL/6
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| MP:0009105 | penis prolapse | "inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
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| MP:0009108 | increased pancreas weight | "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0009109 | decreased pancreas weight | "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0009114 | decreased pancreatic beta cell mass | "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
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| MP:0009131 | decreased white fat cell number | "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0009132 | abnormal white fat cell size | "anomaly in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0009141 | increased prepulse inhibition | "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0009143 | abnormal pancreatic duct morphology | "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0009151 | pancreatic ductal adenocarcinoma | "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0009152 | pancreatic intraepithelial neoplasia | "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Krastm4Tyj/Krastm4Tyj,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Krastm4Tyj/Krastm4Tyj,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0009153 | pancreas tumor | "tumors or cancer of the pancreas" [MESH:C04.588.274.761] |
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Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Pdx1-cre)6Tuv/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0009156 | absent pancreatic acini | "absence of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss
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| MP:0009159 | increased pancreatic acinar cell number | "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009160 | abnormal pancreatic acinar cell zymogen granule | "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0009164 | exocrine pancreas atrophy | "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Kio/Gt(ROSA)26Sor+,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: B6.129-Tnfrsf4tm2(cre)Nik Gt(ROSA)26Sortm1(DTA)Kio
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| MP:0009165 | abnormal endocrine pancreas morphology | "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009167 | increased pancreatic islet number | "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Ntf3tm1Par/Ntf3tm2Jae,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL
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| MP:0009168 | decreased pancreatic islet number | "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0009172 | small pancreatic islets | "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0009173 | absent pancreatic islets | "absence of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0009175 | abnormal pancreatic beta cell differentiation | "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131] |
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL
Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA * SJL
Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(Maml1/EGFP)Hri/?,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
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| MP:0009176 | increased pancreatic alpha cell number | "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009177 | decreased pancreatic alpha cell number | "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: C57BL/6 * CBA/J
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| MP:0009178 | absent pancreatic alpha cells | "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0009179 | abnormal pancreatic alpha cell differentiation | "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hprttm1(Ins2-HBEGF)Herr/Y,Tg(Ins2-cre/ERT)1Dam/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0009180 | increased pancreatic delta cell number | "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854] |
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Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
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| MP:0009219 | prostate intraepithelial neoplasia | "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(JAG1)Xin/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl
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| MP:0009220 | prostate adenocarcinoma | "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(JAG1)Xin/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl
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| MP:0009243 | hairpin sperm flagellum | "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2
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| MP:0009246 | pale spleen | "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0009264 | failure of eyelid fusion | "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0009267 | abnormal cerebellum fissure morphology | "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: En1tm8.1Alj/En1+,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
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| MP:0009269 | decreased fat cell size | "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449] |
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
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| MP:0009272 | decreased guard hair length | "reduction in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities"] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0009274 | buphthalmos | "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0009277 | brain tumor | "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0009278 | abnormal bone marrow cell physiology | "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1Iaai/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Iaai/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Eef1a1tm2Arge/Eef1a1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm1(Bcor*A)Vjba/Gt(ROSA)26Sortm1(Bcor*A)Vjba
Genetic Background: Not Specified
Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0009283 | decreased gonadal fat pad weight | "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn/Gt(ROSA)26Sortm2(STAT3,EGFP)Cgn,Tg(Agrp-cre)1Gsb/?
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0009286 | increased abdominal fat pad weight | "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
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| MP:0009289 | decreased epididymal fat pad weight | |
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Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0009293 | decreased inguinal fat pad weight | |
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Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0009304 | increased retroperitoneal fat pad weight | |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0009309 | small intestine adenocarcinoma | "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
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| MP:0009317 | follicular lymphoma | "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
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| MP:0009321 | histiocytic sarcoma | |
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
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| MP:0009339 | decreased splenocyte number | "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6J
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| MP:0009347 | increased cancellous bone thickness | "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0009352 | impaired spacing of implantation sites | "in organisms which give birth to multiple offspring in one litter, blastocysts fail to implant at intervals conducive to the formation of a normal enveloping membrane or decidua for each conceptus from the epithelial tissue of the endometrium lining of the uterus" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009353 | twin decidual capsule | "two embryos share one decidual membrane" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0009380 | abnormal ventral prostate morphology | |
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Allelic Composition: Slc4a11tm1.1Jrcy/Slc4a11tm1.1Jrcy
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
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| MP:0009385 | abnormal dermal pigmentation | "anomaly in coloration of the dermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0009387 | abnormal epidermal pigmentation | "anomaly in coloration of the epidermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0009389 | abnormal extracutaneous pigmentation | "any anomaly in the coloring of organs and tissues excluding the integument" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0009390 | abnormal auditory pigmentation | |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0009391 | abnormal leptomeninges pigmentation | "any anomaly in the coloring of the two innermost layers of the meninges, including the pia mater and the arachnoid" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0009395 | persistence of primitive erythrocytes | "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0009397 | increased trophoblast giant cell number | "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
Allelic Composition: Gt(ROSA)26Sortm1.1(Ctnna3,EGFP)Jvh/Gt(ROSA)26Sortm1.1(Ctnna3,EGFP)Jvh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
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| MP:0009399 | increased skeletal muscle fiber size | "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
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| MP:0009400 | decreased skeletal muscle fiber size | "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0009403 | increased variability of skeletal muscle fiber size | "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0009404 | centrally nucleated skeletal muscle fibers | "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0009419 | skeletal muscle fibrosis | "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Pax7tm1(cre/ERT2)Gaka/Pax7+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0009420 | skeletal muscle endomysial fibrosis | "replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
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| MP:0009434 | paraparesis | "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0009450 | abnormal axon fasiculation | "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dscamtm1Pfu/Dscamtm1Pfu,Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/?,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0009452 | abnormal synaptonemal complex | "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0009453 | enhanced contextual conditioning | "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0009479 | abnormal cecum development | "malformation or aberrant differentiation of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf10tm1.1(cre/ERT2)Sbel/Fgf10tm1Sms,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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| MP:0009497 | abnormal intrahepatic bile duct morphology | "any structural anomaly of the passages within the liver for the conveyance of bile" [MESH:A03.159.183.158] |
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Allelic Composition: Gt(ROSA)26Sortm2Bet/Gt(ROSA)26Sortm2Bet,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA
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| MP:0009503 | abnormal mammary gland duct morphology | "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
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| MP:0009506 | abnormal mammary gland alveolus morphology | "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0009511 | distended stomach | "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
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| MP:0009516 | enlarged salivary gland | "increased size of the saliva-secreting glands of the oral cavity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009541 | increased thymocyte apoptosis | "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0009542 | decreased thymocyte apoptosis | "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1(cre/ERT)Nat,Tg(H2-K-BCL2)1Josd/0
Genetic Background: involves: 129 * C3H * C57BL/6
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| MP:0009543 | abnormal thymus corticomedullary boundary morphology | "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous
blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature,
functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941] |
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Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
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| MP:0009544 | abnormal thymus epithelium morphology | "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941] |
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd
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| MP:0009546 | absent gastric milk in neonates | "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0009549 | impaired platelet aggregation | "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527] |
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Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0009550 | urinary bladder carcinoma | "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu/Gt(ROSA)26Sor+,Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
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| MP:0009552 | urinary bladder obstruction | "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
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| MP:0009567 | mitotic nondisjuction | "failure of sister-chromatids to separate to the cell poles at anaphase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
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| MP:0009571 | abnormal right lung accessory lobe morphology | |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0009572 | abnormal right lung cranial lobe morphology | |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0009573 | abnormal right lung middle lobe morphology | |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0009577 | abnormal developmental vascular remodeling | "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Xrcc6tm1Fwa/Xrcc6tm1Fwa
Genetic Background: involves: 129S6/SvEvTac
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| MP:0009579 | acephaly | "congenital absence of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0009583 | increased keratinocyte proliferation | "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6 * SJL
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| MP:0009623 | enlarged inguinal lymph nodes | "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
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| MP:0009635 | enlarged popliteal lymph nodes | "increased size of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0009651 | abnormal eyelid development | "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009655 | abnormal secondary palate development | "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009657 | failure of chorioallantoic fusion | "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0009660 | abnormal induced retinal neovascularization | "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Dll4tm2.1Vlcg/Dll4+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac
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| MP:0009663 | abnormal uterine-embryonic axis | "any anomaly in the process whereby the implantation chamber orients in the uterus in response to decidual growth to insure correct alignment of the embryo to the uterus" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009666 | abnormal embryo attachment | "any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009671 | abnormal uterus physiology | "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
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| MP:0009704 | skin squamous cell carcinoma | "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
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| MP:0009713 | enhanced conditioned place preference behavior | "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0009728 | abnormal calcaneum morphology | "any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0009738 | enlarged prostate gland anterior lobe | "increased size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12645922, PMID:3308446] |
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
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| MP:0009743 | preaxial polydactyly | "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv
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| MP:0009744 | postaxial polydactyly | "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433] |
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Allelic Composition: Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/0
Genetic Background: involves: 129S1/Sv
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| MP:0009758 | impaired behavioral response to cocaine | "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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| MP:0009760 | abnormal mitotic spindle | "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia
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| MP:0009762 | abnormal mitotic spindle assembly checkpoint | "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0,Tg(Fev-flpe)1Dym/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009764 | decreased sensitivity to induced morbidity/mortality | "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
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| MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0009768 | impaired somite development | "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan,Tg(T-cre)1Lwd/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
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| MP:0009780 | abnormal chondrocyte physiology | "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0009783 | abnormal melanoblast morphology | "any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell" [CL:0000541] |
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0009784 | abnormal melanoblast migration | "defect in the dispersion of the cells that originate from the neural crest and differentiate into pigment cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0009785 | altered susceptibility to infection induced morbidity/mortality | "differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N
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| MP:0009797 | abnormal mismatch repair | "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0009808 | reduced oligodendrocyte number | "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0009825 | cornea ulcer | "an area of tissue erosion in the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0009828 | delayed tumor appearance | "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0009854 | delayed gastric emptying | "an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Kittm1(cre/ERT2)Dsa/Kit+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
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| MP:0009867 | abnormal ascending aorta morphology | "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0009886 | failure of palatal shelf elevation | "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722] |
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009901 | abnormal frontonasal prominence morphology | "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae *129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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| MP:0009907 | decreased tongue size | "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0009921 | abnormal transitional stage T3 B cell morphology | "any strucutral anomaly of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0009922 | increased transitional stage T1 B cell number | "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111] |
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
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| MP:0009923 | decreased transitional stage T1 B cell number | "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0009926 | decreased transitional stage T2 B cell number | "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111] |
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
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| MP:0009932 | skin fibrosis | "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0009933 | abnormal tail hair pigmentation | "an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0009934 | abnormal hind foot hair pigmentation | "an anomaly in the expected color gradient of hair covering the metatarsals and phalanges often differentially expressed in females and males" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0009936 | abnormal dendritic spine morphology | "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arpc3tm1Ssod/Arpc3tm1Ssod,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: BALB/c * C57BL
Allelic Composition: Gt(ROSA)26Sortm1(ACTB-Map2k5*/EGFP)Zxi/Gt(ROSA)26Sortm14(CAG-tdTomato)Hze,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Ezh2tm1Yugo/Ezh2tm1Yugo,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Rnf2tm1Mvi/Rnf2tm1Mvi
Genetic Background: involves: 129S/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Resttm1.1Jhsi/Resttm1.1Jhsi,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gdpd5tm1Itl/Gdpd5tm1.1Itl,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129/Sv * 129X1/SvJ * C57BL/6J
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| MP:0009957 | abnormal cerebellum vermis lobule morphology | "any structural anomaly of the region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres; in humans, vermis lobule regions may be nearly continuous with the cerebellar hemisphere lobules dorsally but are separated by deeper longitudinal fissues in the ventral regions; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17506688] |
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Allelic Composition: En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm6Alj/En2+,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0009963 | abnormal cerebellum hemisphere lobule morphology | "any structural anomaly of the region of a cerebellar lobule that resides in either of the lateral sections of the cerebellum outside the vermis; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres; distinct species specific differences in hemisphere lobulation occurs among mammals, with greatest complexity in primates" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17506688, PMID:19693030] |
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Allelic Composition: En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm7.1Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0009964 | abnormal cerebellum lobule morphology | "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
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| MP:0009968 | abnormal cerebellar granule cell proliferation | "any anomaly in the ability of a cerebellar granule cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
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| MP:0009969 | abnormal cerebral cortex pyramidal cell morphology | "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas
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| MP:0010013 | cerebral cortex pyramidal cell degeneration | "a retrogressive impairment or destruction of the projection neuron in the pyramidal layer of the cerebral cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ins1tm1Jja/Ins1tm1Jja,Ins2tm1Jja/Ins2tm1Jja
Genetic Background: involves: 129S2/SvPas
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| MP:0010015 | abnormal cuticular plate morphology | "any structural anomaly of the firm laminar network of actin filaments in the organ of Corti to which the apical ends of the cochlear hair cells attach and through which their stereocilia project" [PMID:12324381] |
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Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
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| MP:0010018 | lung vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0010019 | liver vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0010024 | increased total body fat amount | "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl/Gt(ROSA)26Sor+
Genetic Background: B6NTac.Cg-Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/?,Oxttm1.1(cre)Dolsn/Oxt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kif3atm1Noh/Kif3atm1Noh
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbp+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0010031 | abnormal cranium size | "deviation from the average range of cranium size compared to normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0010037 | ectopic melanocytes | "pigment producing cells are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0010038 | abnormal placenta physiology | "any functional anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ctnna3,EGFP)Jvh/Gt(ROSA)26Sortm1.1(Ctnna3,EGFP)Jvh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
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| MP:0010039 | abnormal trophoblast giant cell proliferation | "abnormality in the expansion rate of the trophoblast giant cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0010050 | hypermyelination | "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic Background: involves: C3H * C57BL/6
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| MP:0010072 | increased pruritus | "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0010073 | decreased pruritus | "absence or decreased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Trpv1-cre)1Hoon/0
Genetic Background: involves: 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: C57BL/6
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| MP:0010080 | abnormal hepatocyte physiology | "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sqstm1tm1.1Sral/Sqstm1+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0010097 | abnormal retinal blood vessel morphology | "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(SRF/VP16)Antu/Gt(ROSA)26Sortm1(SRF/VP16)Antu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
Allelic Composition: Pde6batrd1/Pde6btm1Eye,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/cAnN * C3H/HeN * C57BL/6J
Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tg(CAG-ANGPT1*)5Yo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
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| MP:0010098 | abnormal retinal blood vessel pattern | "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
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| MP:0010103 | small thoracic cage | "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0010132 | decreased DN2 thymocyte number | "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806] |
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Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
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| MP:0010144 | abnormal tumor vascularization | "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Ntn4)Dyl/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Hk2tm1.1Uku/Hk2tm1.1Uku,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0010155 | abnormal intestine physiology | "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0010156 | abnormal small intestinal crypt cell physiology | "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm19(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010157 | abnormal small intestinal crypt cell proliferation | "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm19(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010158 | abnormal intestine development | "abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ
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| MP:0010160 | increased oligodendrocyte number | "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sortm1(CAG-Rheb*)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0010171 | abnormal centroacinar cell of Langerhans morphology | "any structural anomaly of cells that line the pancreatic ducts that secrete mucins and an aqueous bicarbonate solution under stimulation by the hormone secretin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0010172 | abnormal mammary gland epithelium physiology | "any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Myc)Rcse/Gt(ROSA)26Sortm1(Myc)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0010174 | decreased mammary gland epithelium proliferation | "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr,Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
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| MP:0010180 | increased susceptibility to weight loss | "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J
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| MP:0010207 | abnormal telomere morphology | "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0010209 | abnormal circulating chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+,Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0010210 | abnormal circulating cytokine level | "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
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| MP:0010219 | increased T-helper 17 cell number | "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899] |
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0010221 | abnormal T-helper 17 cell differentiation | "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv
Genetic Background: involves: C57BL/6
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| MP:0010224 | abnormal heart ventricle outflow tract morphology | "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(Mef2c-cre)2Blk/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0010235 | abnormal retina inner limiting membrane morphology | "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0010236 | abnormal retina outer limiting membrane morphology | "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0010268 | decreased lymphoma incidence | "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Hes1tm1.1Frad/Hes1tm1.1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tacc3tm1.1Tno/Tacc3tm1.2Tno,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
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| MP:0010269 | decreased mammary gland tumor incidence | "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
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| MP:0010274 | increased organ/body region tumor incidence | "greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0010275 | increased melanoma incidence | "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Braftm1Tuv/Braftm1Tuv,Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+,Tg(Tyr-cre/ERT2)13Bos/0,TgTn(sb-T2/Onc)#Dla/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL
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| MP:0010276 | increased intraocular melanoma incidence | "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the uvea of the eye, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0010277 | increased astrocytoma incidence | "greater than the expected number of tumors that arise from astrocytes, large neuroglia cells of nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0,Tg(GFAP-EGFR*,-lacZ)#Agu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
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| MP:0010278 | increased glioma incidence | "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0,Tg(GFAP-EGFR*,-lacZ)#Agu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
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| MP:0010279 | increased gastrointestinal tumor incidence | "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)68Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
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| MP:0010281 | increased nervous system tumor incidence | "greater than the expected number of tumors originating in the nervous system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0010286 | increased plasmacytoma incidence | "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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| MP:0010294 | increased kidney tumor incidence | "greater than the expected number of tumors originating in the kidney in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0010296 | increased hemolymphoid system tumor incidence | "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Aicdatm1(cre)Mnz/Aicda+,Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm2.1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)
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| MP:0010300 | increased skin tumor incidence | "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010307 | abnormal tumor latency | "anomaly in the expected time of onset of tumor occurrence" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0010308 | decreased tumor latency | "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0,Tg(GFAP-EGFR*,-lacZ)#Agu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0010312 | increased oligodendroglioma incidence | "greater than the expected number of encapsulated neoplasms derived from oligodendrocytes, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(RICTOR)Jger/Gt(ROSA)26Sortm1(RICTOR)Jger,Tg(GFAP-cre)25Mes/0,Tg(GFAP-EGFR*,-lacZ)#Agu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
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| MP:0010315 | increased cholangiocarcinoma incidence | "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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| MP:0010320 | increased pituitary gland tumor incidence | "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(myc*T58A)Rcse/Gt(ROSA)26Sortm2(myc*T58A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Gfap-cre)2Brn/0
Genetic Background: either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
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| MP:0010336 | increased acute lymphoblastic leukemia incidence | |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0010357 | increased prostate gland tumor incidence | "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
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| MP:0010359 | increased liver free fatty acids level | "elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0010363 | increased fibrosarcoma incidence | "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
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| MP:0010373 | myeloid hyperplasia | "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010377 | abnormal gut flora balance | "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tyrem2Utr/Tyrem2Utr
Genetic Background: involves: C57BL/6J
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| MP:0010378 | increased respiratory quotient | "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0010382 | abnormal dosage compensation, by inactivation of X chromosome | "anomaly in the process of compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex" [GO:0009048] |
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Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0010383 | increased adenoma incidence | "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
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| MP:0010387 | abnormal Bergmann glial cell morphology | "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tg(Nes-cre/Esr1*)1Kuan/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
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| MP:0010395 | abnormal branchial arch development | "abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0010398 | decreased liver glycogen level | "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm6(cre)Bld/Tbx1+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm1Bld/Tbx1tm6(cre)Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0010466 | vascular ring | "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0010519 | atrioventricular block | "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv
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| MP:0010522 | aorta calcification | "pathologic deposition of calcium salts in the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm2(ATF4)Myz/Gt(ROSA)26Sortm2(ATF4)Myz,Tg(Myh11-cre/ERT2)1Soff/?
Genetic Background: either: D2.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff or B6.Cg-Atf4tm1.1Cmad Tg(Myh11-cre/ERT2)1Soff
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| MP:0010531 | gastrointestinal arteriovenous malformation | "congenital vascular anomaly in the gastrointestinal system characterized by direct communication between an artery and a vein without passing through the capillary bed" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ
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| MP:0010537 | tumor regression | "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Alms1L2131X/Alms1L2131X
Genetic Background: involves: C57BL/6 * NOD
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J
Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010584 | abnormal conotruncus septation | "anomaly in the process in which the conotruncus separates into the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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| MP:0010630 | abnormal cardiac muscle tissue morphology | "any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
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| MP:0010632 | cardiac muscle necrosis | "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0010639 | altered tumor pathology | "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0010656 | thick myocardium | "increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(Mef2c-cre)2Blk/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0010710 | absent sclera | "absence of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea" [MESH:A09.371.784] |
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Allelic Composition: Pitx2tm1.1Sac/Pitx2tm2Sac,H2afvTg(Wnt1-cre)11Rth/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0010725 | thin interventricular septum | "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0010727 | increased glioblastoma incidence | "greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord" [NCI:CDRID45698 "http://www.cancer.gov/dictionary/?CdrID=45698"] |
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Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
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| MP:0010741 | abnormal melanocyte proliferation | "anomaly in the ability of the a melanocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0010754 | abnormal heart left ventricle pressure | "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0010763 | abnormal hematopoietic stem cell physiology | "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Bcl11atm2.1Peli/Bcl11atm2.1Peli,Trp53tm1Brn/Trp53tm1Brn,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv
Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Kdm6atm1.1Afst/Kdm6atm1.1Afst,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NTac
Allelic Composition: Nle1tm1Cba/Nle1tm1.1Cota,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
Allelic Composition: Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
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| MP:0010769 | abnormal survival | "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0010784 | abnormal forestomach morphology | "any structural anomaly of the dilated area of tissue where the stomach and esophagus meet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmpr1a)Que/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/?
Genetic Background: Not Specified
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| MP:0010792 | abnormal stomach mucosa morphology | "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Pi4katm1.1Arte/Pi4katm1.1Arte,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0010796 | abnormal intermediate gastric gland morphology | "any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that secrete most of the digestive substances secreted by the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010802 | abnormal intestinal enteroendocrine cell morphology | "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
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| MP:0010809 | abnormal Clara cell morphology | "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: A/A,Tyrc-ch/Tyrc-ch
Genetic Background: Not Specified
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| MP:0010868 | increased bone trabecula number | "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0010872 | increased trabecular bone mass | "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
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| MP:0010873 | decreased trabecular bone mass | "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0010875 | increased bone volume | "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-RNAi:Hivep3)Glm/Gt(ROSA)26Sor+
Genetic Background: Not Specified
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| MP:0010876 | decreased bone volume | "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
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| MP:0010878 | increased trabecular bone volume | "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0010879 | decreased trabecular bone volume | "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0010896 | decreased lung compliance | "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0010898 | abnormal pulmonary alveolus epithelium morphology | "any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sor+,Tg(SFTPC-rtTA)5Jaw/0
Genetic Background: Not Specified
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| MP:0010899 | abnormal pulmonary alveolar system morphology | |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/0,Tg(Sftpc-Grem1)105Mmyl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
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| MP:0010900 | abnormal pulmonary interalveolar septum morphology | "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
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| MP:0010906 | abnormal lung bud morphology | "any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf10tm1.1(cre/ERT2)Sbel/Fgf10tm1Sms,Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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| MP:0010910 | bronchiolar epithelial hyperplasia | "increased size, often due to increased epithelial cell number, of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0010918 | abnormal pulmonary neuroendocrine bodies | "any structural anomaly of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: A/A,Tyrc-ch/Tyrc-ch
Genetic Background: Not Specified
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| MP:0010923 | pulmonary alveolar calcification | "pathologic deposition of calcium salts in the pulmonary alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H
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| MP:0010933 | decreased trabecular bone connectivity density | "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0010934 | increased subcutaneous adipose tissue amount | "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0010935 | increased airway resistance | "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0010945 | lung epithelium hyperplasia | "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0010948 | abnormal double-strand DNA break repair | "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302] |
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Allelic Composition: Gt(ROSA)26Sortm1(RNU6-RNAi:Rad18)Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0010951 | abnormal lipid oxidation | "anomaly in the process of removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0034440] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Tardbptm1.1Pcw/Tardbptm1.1Pcw
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0010954 | abnormal cellular respiration | "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333] |
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Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0010955 | abnormal respiratory electron transport chain | "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0010959 | abnormal oxidative phosphorylation | "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0010968 | decreased compact bone area | "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic Background: involves: 129S4/SvJae
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| MP:0010975 | abnormal lung lobe morphology | "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0010976 | small lung lobe | "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0010979 | small ureteric bud | "reduced size of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308] |
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Allelic Composition: Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd,Tg(Hoxb7-cre)13Amc/0,Tg(Hoxb7-EGFP)33Cos/0
Genetic Background: involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
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| MP:0010985 | abnormal kidney mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0011004 | abnormal epidermal stem cell morphology | "any structural anomaly of a somatic stem cell that is part of the epidermis" [CL:1000428] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
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| MP:0011028 | impaired branching involved in bronchus morphogenesis | |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
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| MP:0011044 | increased lung elastance | "faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0011050 | abnormal respiratory motile cilium morphology | "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Igf1rtm1Jcbr/Igf1rtm1Jcbr,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: C57BL/6
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| MP:0011082 | abnormal gastrointestinal motility | "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Kittm1(cre/ERT2)Dsa/Kit+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf6tm1(cre)Mrc/Myf6tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sortm1(Tbx1/GFP)Bem,Tbx1tm6(cre)Bld/Tbx1+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Rad50tm3Jpt/Rad50tm4.1Jpt
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Rad50tm1Jpt/Rad50tm3Jpt,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm2Hyn/Itgav+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+,Tg(Neurog1-cre)1Jejo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Trp53tm1Brn/Trp53tm1Brn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+,Tfrctm3.1Nca/Tfrctm3.1Nca,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf6tm1(cre)Mrc/Myf6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm2Sev/Isl1tm2Sev,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S5/SvEvBrd * C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: C57BL/6
Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(DTR/EGFP)Fjs,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N
Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
Allelic Composition: Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan,Tg(T-cre)1Lwd/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
Allelic Composition: Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol,Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gli3Xt-J/Gli3Xt-J,Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster
Allelic Composition: Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sor+,Tg(SFTPC-rtTA)5Jaw/0
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+,Nf1tm1Fcr/Nf1tm1Par,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)H39Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)H8Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/?
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Dph1tm2Bhr/Dph1+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Edil3Tg(Sox2-cre)1Amc/0,Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Smad7-cre)1Sjc/0
Genetic Background: involves: 129S/Sv * C3HeB/FeJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre/Esr1*)1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm4(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1
Allelic Composition: Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2Wbaa/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmpr1a)Que/Gt(ROSA)26Sor+,Shhtm1(EGFP/cre)Cjt/?
Genetic Background: Not Specified
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
Allelic Composition: Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Olig3tm1(cre)Ynka/Olig3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)H5Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP1)H12Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H31Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/cJ * C57BL/6
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| MP:0011107 | partial embryonic lethality before turning of embryo | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J
Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
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| MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
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| MP:0011156 | abnormal hypodermis fat layer morphology | "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8] |
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0011167 | abnormal adipose tissue development | "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0011169 | abnormal white fat cell differentation | "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0011174 | lipodystrophy | "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0011182 | decreased hematopoietic cell number | "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith] |
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011183 | abnormal primitive endoderm morphology | "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814] |
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J
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| MP:0011186 | abnormal visceral endoderm morphology | "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Eomestm1Rob/Eomestm1.1Rob,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
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| MP:0011187 | abnormal parietal endoderm morphology | "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946] |
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Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011194 | abnormal hair follicle physiology | "any functional anomaly of the invagination of the epidermis from which the hair shaft develops" [MESH:A10.272.497.500, MGI:mnk] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011195 | increased hair follicle apoptosis | "greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [MGI:mnk] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Corintm2(cre)Bamo/Corin+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011210 | abnormal temporomandibular joint morphology | "any structural anomaly of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones" [ISBN:0-683-40008-8] |
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6
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| MP:0011255 | abnormal anterior visceral endoderm cell migration | "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044] |
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Allelic Composition: Rbm44tm1.1Zuk/Rbm44+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(Lyn/Celsr1/EGFP)Rodr/Gt(ROSA)26Sor+
Genetic Background: involves: FVB/N
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| MP:0011276 | increased tail pigmentation | "visually detectable excess of pigment present on the tail surface" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0011285 | increased circulating erythropoietin level | "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
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| MP:0011287 | increased erythropoietin level | "greater fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl
Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Hif1atm3Rsjo/Hif1atm3Rsjo
Genetic Background: B6.Cg-Gt(ROSA)26Sortm9(cre/ESR1)Arte Egln1tm2.1Fsl Hif1atm3Rsjo
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| MP:0011294 | renal glomerulus hypertrophy | "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
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| MP:0011309 | abnormal kidney arterial blood vessel morphology | "any structural anomaly of the network of tubes that supply blood to the renal tissues" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(Tgfbr1*)Crm/Gt(ROSA)26Sor+,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
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| MP:0011334 | abnormal nephrogenic zone morphology | "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0011339 | abnormal glomerular mesangium morphology | "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0011346 | renal tubule atrophy | "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm3(tetO-Mir193)Arte/Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0011353 | expanded mesangial matrix | "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+,Tg(NPHS2-icre/ERT2)1Dnsh/0
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0011371 | decreased kidney apoptosis | "decrease in the number of cells of the kidney undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0011377 | renal glomerulus fibrosis | "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
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| MP:0011387 | absent metanephric mesenchyme | "absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0011388 | absent heart | "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
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| MP:0011394 | increased fetal cardiomyocyte proliferation | "increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0011400 | complete lethality | "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2] |
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Allelic Composition: Gpx4tm1.1Qra/Gpx4tm1.1Qra,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn/Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
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| MP:0011409 | increased renal glomerulus basement membrane thickness | "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna] |
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Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Tg(Nphs1-rtTA*3G)8Jhm/0,Tg(tetO-COL4A3/Col4a3)#aJhm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0011427 | mesangial cell hyperplasia | "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky,Tg(CD2-icre)4Kio/0
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
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| MP:0011430 | mesangiolysis | "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna] |
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Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
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| MP:0011440 | increased kidney cell proliferation | "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna] |
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Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0011448 | decreased dopaminergic neuron number | "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Tg(Tcfap2a-cre)1Will/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0011452 | decreased susceptibility to dopaminergic neuron neurotoxicity | "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sor+,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0011457 | abnormal metanephric ureteric bud development | "any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros" [GO:0035502] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0011496 | abnormal head size | "anomaly in the average size of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0011498 | abnormal glomerular capsule parietal layer morphology | "any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium" [MGI:anna] |
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Allelic Composition: Trp53tm4Xu/Trp53tm4Xu
Genetic Background: Not Specified
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| MP:0011521 | decreased placental labyrinth size | "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011585 | decreased alkaline phosphatase activity | "reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011628 | increased mitochondria number | "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0011629 | decreased mitochondria number | "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011630 | increased mitochondria size | "enlarged the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011632 | dilated mitochondria | "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith] |
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Allelic Composition: Afg3l2tm1Arte/Afg3l2tm1Arte,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: C57BL/6J
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0011633 | abnormal mitochondrial shape | "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011634 | abnormal mitochondrial inner membrane morphology | "any structural anomaly of the inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope, which is highly folded to form cristae" [GO:0005743] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011642 | abnormal bone collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0011643 | abnormal tendon collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
Allelic Composition: Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N
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| MP:0011677 | abnormal olfactory sensory neuron physiology | "any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals" [MGI:csmith] |
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Allelic Composition: Panx3tm1d(KOMP)Wtsi/Panx3tm1d(KOMP)Wtsi
Genetic Background: involves: BALB/cJ * C3H * C57BL/6 * C57BL/6N
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| MP:0011682 | renal glomerulus cysts | "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
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| MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Lin9tm1.1Sgau/Lin9tm1.1Sgau
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+,Ppp1r13ltm1Xlu/Ppp1r13ltm1Xlu
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0011705 | absent fibroblast proliferation | "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * SJL
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| MP:0011706 | abnormal fibroblast migration | "any anomaly of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [GO:0010761] |
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo
Allelic Composition: Chuktm1Lex/Chuktm1Lex,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S/SvEvBrd * C57BL/6
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| MP:0011708 | decreased fibroblast cell migration | "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith] |
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo
Allelic Composition: Chuktm1Lex/Chuktm1Lex,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S/SvEvBrd * C57BL/6
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| MP:0011723 | ectopic neuron | "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0011730 | increased myelin sheath thickness | "increase in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb] |
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011731 | decreased myelin sheath thickness | "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb] |
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Allelic Composition: Erbb3tm3Cbm/Erbb3tm3Cbm,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2
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| MP:0011732 | decreased somite size | "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb] |
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Allelic Composition: Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan,Tg(T-cre)1Lwd/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J
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| MP:0011743 | abnormal Golgi apparatus morphology | "any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry] |
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(BGLAP-cre)1Clem/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/NJ
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| MP:0011747 | myelofibrosis | "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
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| MP:0011748 | intestinal fibrosis | "formation of fibrous tissue in any part of the intestine as a result of repair or a reactive process" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm13Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Pdgfratm12Sor/Pdgfra+
Genetic Background: involves: 129 * 129/Sv * C57BL/6J * SJL
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| MP:0011771 | abnormal genital tubercle morphology | "any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation" [MGI:anna] |
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Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl
Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt
Genetic Background: involves: 129S6/SvEvTac
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| MP:0011775 | rectal atresia | "congenital absence, closure, or constriction of the lumen of the terminal portion of the intestinal tube adjacent to the anus, leading to abdominal distention after birth" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0011786 | rectourethral fistula | "an abnormal anatomical passage connecting the urethra and the rectum" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0011820 | decreased pancreatic beta cell proliferation | "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0011901 | abnormal hematopoietic stem cell proliferation | "anomaly in the ability of a hematopoietic stem cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011902 | increased hematopoietic stem cell proliferation | "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011922 | abnormal circulating osteocalcin level | "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
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| MP:0011932 | abnormal endocrine pancreas development | |
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Allelic Composition: Ntf3tm1Par/Ntf3tm2Jae,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL
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| MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+,Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Fto)Rdc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0011940 | decreased food intake | "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0011942 | decreased fluid intake | "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0011952 | decreased cardiac stroke volume | "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+,Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze Hiratm1c(EUCOMM)Wtsi/Hiratm1d(EUCOMM)Wtsi Tg(Myh6-cre)2182Mds
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| MP:0011960 | abnormal eye anterior chamber depth | "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls" [MGI:csmith] |
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr
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| MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0011994 | increased nerve conduction velocity | "increase in the rate at which an electrical impulse travels through a nerve" [MGI:csmith] |
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0012021 | abnormal melanocyte number | "deviation from the average number of the cells that produce pigment" [MGI:llw2] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Mitf-cre)7114Gsb/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Mitf-cre)7114Gsb
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| MP:0012023 | decreased melanocyte number | "reduced number of the cells that produce pigment" [MGI:llw2] |
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Allelic Composition: Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sor+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr Tg(Tyr-cre/ERT2)13Bos
Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N
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| MP:0012049 | increased susceptilbility to retinal ischemic injury | "increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina" [MGI:csmith] |
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
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| MP:0012050 | decreased susceptilbility to retinal ischemic injury | "decreased frequency or less severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tg(CAG-ANGPT1*)5Yo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0012065 | increased astrocyte number | "increase in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+,Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tg(CAG-ANGPT1*)5Yo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0012066 | decreased astrocyte number | "reduction in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith] |
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
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| MP:0012075 | impaired mammary gland growth during pregnancy | "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2] |
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Allelic Composition: Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: C57BL/6-Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte
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| MP:0012082 | delayed heart development | "late onset of the induction and/or differentiation of the heart" [MGI:anna] |
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0012087 | absent midbrain | "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0012089 | decreased midbrain size | "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0012100 | absent spongiotrophoblast | "absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith] |
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Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0012133 | absent midbrain-hindbrain boundary | "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm3Kba,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0012138 | decreased forebrain size | "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm2Jpmb
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0012141 | absent hindbrain | "absence of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived; the metencephalon (anterior part of the embryonic hindbrain), gives rise to the cerebellum and pons while the myelencephalon (posterior portion of the embryonic hindbrain) gives rise to the medulla oblongata" [MGI:anna] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA/J
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| MP:0012174 | flat head | "the appearance of a flattened surface outline or contour of a normally rounded head of an organism" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012176 | abnormal head development | "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323] |
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Allelic Composition: Smotm1Amc/Smotm2Amc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6J * CBA/J
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| MP:0012179 | abnormal splanchnic mesoderm morphology | "any structural abnormality of the inner layer of lateral plate mesoderm, located above (dorsally) the endoderm, which forms the circulatory system and future gut wall" [MGI:anna] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
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| MP:0012183 | decreased paraxial mesoderm size | "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI
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| MP:0012200 | increased endothelial cell proliferation | |
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Allelic Composition: Flt1tm1.1Fong/Flt1tm1.1Fong,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
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| MP:0012201 | decreased endothelial cell proliferation | |
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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| MP:0012204 | abnormal neuronal stem cell physiology | "any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047] |
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst
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| MP:0012206 | increased neuronal stem cell self-renewal | "an increased rate in the process by which stem cells divide and proliferate to make more stem cells, perpetuating an increase in the stem cell pool; self-renewal is division with maintenance of the undifferentiated state" [PMID:19575646] |
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Allelic Composition: Tbc1d1Gt(E140H06)Wrst/Tbc1d1Gt(E140H06)Wrst
Genetic Background: B6.129P2-Tbc1d1Gt(E140H06)Wrst
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| MP:0012306 | enhanced spatial learning | "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith] |
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Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc
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| MP:0012362 | increased large unstained cell number | "increased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts" [MPD:Molly, PMID:10388493] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0012424 | decreased alimentary system tumor incidence | "less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [MGI:csmith] |
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Allelic Composition: ApcMin/Apc+,Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sor ApcMin
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6057Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc2)6113Njen/0
Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,TgTn(sb-T2/Onc3)12740Njen/0
Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+,Tg(Nes-cre)1Wmz/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)S2Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H32Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP2)H27Brd/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
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| MP:0012490 | abnormal cochlear VIII nucleus morphology | "any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith] |
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Allelic Composition: Hoxb1tm1Mist/Hoxb1tm1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
Allelic Composition: Hoxb1tm1.1Mist/Hoxb1tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
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| MP:0012556 | increased cell death | "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432] |
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA
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| MP:0012674 | tomacula | "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb] |
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0012709 | delayed caudal neuropore closure | "a delay in the joining together of the neural folds of the caudal opening of the neural tube" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012733 | abnormal behavioral response to methamphetamine | "anomaly in the behavioral response induced by methamphetamine such as induced hyperactivity or stereotypic behavior" [MPD:Molly] |
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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| MP:0012747 | abnormal cardiac neural crest cell morphology | "any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J
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| MP:0012748 | increased cardiac neural crest cell number | "greater than expected number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0012749 | decreased cardiac neural crest cell number | "reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna] |
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2afvTg(Wnt1-cre)11Rth
Allelic Composition: Smotm2Amc/Smotm2.1Amc,H2afvTg(Wnt1-cre)11Rth/0,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0012751 | impaired cardiac neural crest cell differentiation | "abnormal or arrest of differentiation or patterning of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs have the potential to differentiate into smooth muscle cells of the cardiac outflow tract and its septum, walls of aortic and arch-derived arteries, all of the parasympathetic innervation of the heart, and the connective tissue of the glands in the head and neck region, including the thymus, thyroid and parathyroid glands" [MGI:anna] |
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Allelic Composition: Smotm2Amc/Smotm2.1Amc,H2afvTg(Wnt1-cre)11Rth/0,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0012752 | abnormal cardiac neural crest cell migration | "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna] |
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Allelic Composition: Fgf15tm1Sms/Fgf15tm1Sms,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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| MP:0012756 | impaired cranial neural crest cell differentiation | "abnormal or arrest of differentiation or patterning of the cranial neural crest cells" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2afvTg(Wnt1-cre)11Rth
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| MP:0012785 | decreased rhombomere 1 size | "reduced size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna] |
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Allelic Composition: En1tm7(cre/ESR1)Alj/En1+,En2tm2Alj/En2tm2Alj,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
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| MP:0013006 | abnormal enteric neural crest cell migration | "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)" [MGI:anna, PMID:17514199] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0013139 | moribund | "in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive" [MGI:Ahmad_Retha] |
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Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0013180 | truncated tail bud | "shortened tail bud that terminates in a blunt end (instead of a tapered end)" [MGI:anna] |
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Cdx1-cre)23Kem/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
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| MP:0013184 | hemorrhagic ascites | "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna] |
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0013203 | abnormal primary cilium morphology | "any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372] |
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0013221 | pancreatic acinar-to-ductal metaplasia | "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Tg(Cela1-cre/ERT)1Dam/0
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0013225 | abnormal third pharyngeal pouch morphology | "any structural anomaly of the third endodermal branchial pouch located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium" [PMID:20144910] |
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Allelic Composition: Foxn1tm3(cre)Nrm/Foxn1+,Gt(ROSA)26Sortm1(Tbx1)Rche/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NHsd
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| MP:0013237 | abnormal skeletal muscle regeneration | "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
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| MP:0013239 | impaired skeletal muscle regeneration | "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith] |
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Allelic Composition: Kdm6atm1.1Kaig/Kdm6atm1.1Kaig,Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0013278 | decreased fasted circulating glucose level | "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza] |
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Allelic Composition: Gt(ROSA)26Sortm1(Gck)Ydor/Gt(ROSA)26Sor+,Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0013289 | abnormal mitotic cytokinesis | "any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission" [GO:0000281, MGI:smb] |
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Allelic Composition: Suz12Plt8/Suz12+
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0013293 | embryonic lethality prior to tooth bud stage | "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb] |
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Allelic Composition: Ripk3tm2Vmd/Ripk3tm2Vmd,Tnfrsf25tm1Lex/Tnfrsf25tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N
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| MP:0013307 | increased adrenal gland weight | "greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla " [MGI:Anna] |
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Allelic Composition: Sptlc2tm1Yhir/Sptlc2tm1Yhir,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0013335 | hepatic peliosis | "presence of cyst-like blood-filled lakes or cavities that lack endothelial linings in the liver parenchyma" [MGI:Anna, PMID:15734106] |
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Allelic Composition: Ap3b1pe/Ap3b1pe,Hps1ep/Hps1ep
Genetic Background: involves: C3H/He * C3HeB/FeJ * C57BL/6J
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| MP:0013374 | increased sebaceous gland tumor incidence | "greater than the expected number of neoplams in the sebaceous gland occurring in a specific population in a given time period" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0013464 | decreased conjunctiva goblet cell number | "fewer than normal numbers of the mucin-secreting cells found on the conjunctival epithelium; goblet cell loss has been reported in several inflammatory diseases of the ocular surface, including Stevens-Johnson syndrome, ocular mucous membrane pemphigoid, alkali burn, neutrophilic keratitis, graft-versus-host-disease, and Sjogrens s syndrome" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0013465 | abnormal conjunctiva goblet cell differentiation | "abnormal or arrested formation of the mucin-secreting cells of the conjunctival epithelium from conjunctival precursor/stem cells; in mice, mucin-rich goblet cells normally emerge from the conjunctival epithelium around P7-P9, increase in number and form goblet cell clusters between the second and third week of postnatal development" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0013481 | abnormal ileum crypts of Lieberkuhn morphology | "any structural anomaly of the intestinal crypts located in the mucosa of the ileum, the portion of the small intestine that extends from the jejunum to the colon" [MGI:Anna] |
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Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
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| MP:0013482 | abnormal duodenum crypts of Lieberkuhn morphology | "any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Anna] |
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Allelic Composition: Bmi1tm1(cre/ERT)Mrc/Bmi1+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0013483 | abnormal jejunum crypts of Lieberkuhn morphology | "any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [MGI:Anna] |
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Allelic Composition: Bmi1tm1(cre/ERT)Mrc/Bmi1+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0013485 | increased Paneth cell number | "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6
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| MP:0013488 | increased keratoacanthoma incidence | " greater than the expected number of low-grade skin tumors that originate in the pilosebaceous glands and closely resemble squamous cell carcinoma, occurring in a specific population in a given time period; keratoacanthomas are spontaneously regressing growths that rarely develop into invasive or metastatic carcinoma; in rare instances, multiple keratoacanthomas are associated with a disease process called Muir-Torre syndrome" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0013600 | testis degeneration | "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna] |
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0013623 | increased femur compact bone thickness | "increased width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0013630 | increased bone trabecular spacing | "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0013631 | decreased bone trabecular spacing | "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0013639 | decreased bone stiffness | "decrease in material stiffness (N/mm) during elastic deformation" [MGI:jwhite] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0013663 | increased myeloid cell number | "greater than the expected number of cells of the myeloid lineage" [CL:0000763] |
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N
Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013696 | increased granulocyte monocyte progenitor cell number | "increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251] |
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013701 | abnormal mature B cell number | "anomaly in the number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785] |
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
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| MP:0013744 | abnormal conjunctival sac morphology | "any structural anomaly of the space bound by the conjunctival membrane between the palpebral and bulbar conjunctiva, into which the lacrimal fluid is secreted; it is a closed space when eye is closed; when eye is open, the sac is open anteriorly through the palpebral fissure (between the eyelids)" [http://www.medilexicon.com/medicaldictionary.php?t=79277, MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB
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| MP:0013795 | abnormal colon goblet cell morphology | "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481] |
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Allelic Composition: Krastm4Tyj/Kras+,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae
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| MP:0013805 | myeloid metaplasia | "a progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow, and the marrow is replaced by fibrous (scar) tissue; may lead to anemia, enlarged spleen, the presence of nucleated red blood cells and immature granulocytes in the blood, and the occurrence of extramedullary hematopoiesis in the spleen and liver" [ISBN:0781727286] |
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013905 | preputial gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in any of the paired, lobulated, modified sebaceous glands located in the inguinal region adjacent to the penis and vagina, with pheromonal functions in male rodents; in males, the preputial gland empties into the preputial cavity and in females, the preputial (aka clitoral) gland duct empties into the clitoral fossa" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sortm1.1(DUX4*)Plj
Genetic Background: B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj
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| MP:0013940 | abnormal plasmablast number | "anomaly in the number of an activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative" [CL:0000980] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0013958 | decreased small intestine length | "reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088] |
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0014062 | nervous system inclusion bodies | "nuclear or cytoplasmic aggregates of stainable substances within cells of the nervous system" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm47(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
Allelic Composition: Gt(ROSA)26Sortm48(HTT)Arte/Gt(ROSA)26Sor+
Genetic Background: Not Specified
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| MP:0014076 | absent Paneth cells | "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cdc42tm1Brak/Cdc42tm1Brak,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0014077 | ectopic Paneth cells | "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna] |
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Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Allelic Composition: Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm19(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0014078 | small intestinal villus atrophy | "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Elavl1tm1Thla/Elavl1tm1Thla,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129
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| MP:0014080 | fused small intestinal villi | "partial or complete fusion of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0014082 | decreased small intestinal villus height | "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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| MP:0014083 | blunted small intestinal villi | "abnormal flattening of the surface of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually due to intestinal damage or injury" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ripk3tm1Arte/Ripk3tm1Arte
Genetic Background: involves: C57BL/6NTac
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| MP:0014101 | decreased chondrocyte proliferation | "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988] |
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Allelic Composition: Gt(ROSA)26Sortm1(Wnt4)Bhr/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
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| MP:0014106 | delayed chondrocyte differentiation | "delay in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062] |
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Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1
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| MP:0014126 | increased mammary gland apoptosis | "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(Myc)Rcse/Gt(ROSA)26Sortm1(Myc)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL
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| MP:0014134 | abnormal embryo morphology | "any structural anomaly of an embryo " [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0014141 | abnormal mesoderm morphology | "any structural anomaly of the middle germ layer of the embryo, between the endoderm and ectoderm" [UBERON:0000926] |
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Pkn2tm1c(KOMP)Wtsi/Pkn2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * C57BL/6NTac
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| MP:0014143 | decreased body fat mass | "decreased physical bulk or volume of fat in the whole body" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0014172 | decreased fatty acid oxidation | |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0014174 | decreased fatty acid beta-oxidation | "decreased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0014179 | abnormal blood-retinal barrier function | "anomaly in the function of the part of the blood-ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina; the BRB consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina; the BRB barrier becomes more leaky in patients with diabetic retinopathy" [https://en.wikipedia.org/wiki/Blood%E2%80%93retinal_barrier] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/?,Tg(Rlbp1-cre/ERT2)1Wshn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA
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| MP:0014185 | cerebellum atrophy | "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna] |
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Allelic Composition: Atoh1tm3Hzo/Atoh1tm1Hzo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ
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| MP:0014186 | epididymis hypertrophy | "increase in the bulk size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens due to cell enlargement" [] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0014187 | spermatocele | "a retention cyst of a tubule of the rete testis or the head of the epididymis distended with barely watery fluid that contains spermatozoa" [http://medical-dictionary.thefreedictionary.com/spermatocyst, https://en.wikipedia.org/wiki/Spermatocele] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0014188 | epididymis fibrosis | "invasion of fibrous connective tissue into the epididymis, often resulting from inflammation or injury" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0014192 | increased epididymal cell proliferation | "increase in the expansion rate of any epididymal cell population by cell division" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0014194 | increased epididymal epithelium cell proliferation | "increase in the expansion rate of the cells of the epididymal epithelium by cell division" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Loxl2)Acan/Gt(ROSA)26Sortm1.1(Loxl2)Acan
Genetic Background: Not Specified
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| MP:0020039 | increased bone ossification | "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Ack/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Tg(Runx2-rtTA*M2)#Flng/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac
Allelic Composition: Acvr1tm2.1Vlcg/Acvr1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0020040 | decreased bone ossification | "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0020067 | increased neocortex size | "greater than average size of the neocortex" [GOC:NV] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-TMEM14B,-EGFP)Xqw/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0020080 | increased bone mineralization | "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6
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| MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: FVB/N
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| MP:0020138 | delayed bone mineralization | "late onset of the process by which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Tg(Col2a1-cre)1Bhr/?,Trip11tm1.1Psmi/Trip11tm1.2Psmi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL/J
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| MP:0020186 | altered susceptibility to bacterial infection | "a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [GOC:NV] |
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Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J
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| MP:0020327 | abnormal capillary branching pattern | "any changes in the placement, morphology or number of divisions of the capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMID:14713950] |
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0020329 | decreased capillary density | "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Tsixtm1.1Awu/Tsix+,Tg(CAG-EGFP)50Osb/0,Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sortm1(rtTA)Awu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C3H/HeSlc * C57BL/6J * C57BL/6Slc
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| MP:0020354 | increased endoplasmic reticulum stress | "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/?,Tmem258tm1.1(KOMP)Vlcg/Tmem258+
Genetic Background: involves: C57BL/6NTac
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| MP:0020367 | increased heart iron level | "increase in the amount of iron present in the heart tissue" [MGI:Anna] |
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Allelic Composition: Lama2dy/Lama2dy
Genetic Background: 129P1/Re
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| MP:0020369 | increased intestinal iron level | "increase in the amount of iron present in the large or small intestinal tissue" [MGI:Anna] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Aco1*)Mwh/Gt(ROSA)26Sortm1.1(Aco1*)Mwh
Genetic Background: B6.129P2(129S1)-Gt(ROSA)26Sortm1.1(Aco1*)Mwh
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| MP:0020383 | decreased kidney epithelial cell primary cilium length | "decreased length of the cilia on cells of the renal tubule or collecting duct" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Ttc21btm2c(KOMP)Wtsi/Ttc21baln,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
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| MP:0020409 | abnormal cardiac thrombosis | "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0020410 | increased liposarcoma incidence | "greater than the expected number of malignant tumors derived from primitive or embryonal lipoblastic cells; these may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid, round-celled, or pleomorphic" [MESH:D008080, PMID:27573812] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ
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| MP:0020411 | increased abdominal adipose tissue amount | "increase in amount of adipose tissue associated with internal organs" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Tg(Pomc-EGFP)1Low/0,Tg(Gnrh1-cre)1Dlc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
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| MP:0020416 | decreased fibroblast chemotaxis | "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695] |
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo
Allelic Composition: Chuktm1Lex/Chuktm1Lex,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * 129S/SvEvBrd * C57BL/6
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| MP:0020431 | decreased platelet alpha-granule number | "decreased number of platelet alpha-granules" [] |
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Allelic Composition: Vps33btm1.1Arte/Vps33btm1.1Arte,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6J
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| MP:0020476 | abnormal circardian behavior entrainment | "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649] |
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Opn4tm1(cre)Sapa/Opn4+
Genetic Background: involves: 129S * C57BL/6
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| MP:0020521 | browned white adipose tissue morphology | "white adipose tissue displays a morphology more closely resembling brown adipose tissue (eg. multilocular droplets, decreased lipid droplet size) including the emergence or brown or beige adipocytes in white adipose tissue; this may represent adaptation to increased thermogenic demand, exercise, injury (thermal injury), and/or disease (cancer)" [MGI:mperry, PMID:24531262, PMID:27397607] |
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Allelic Composition: Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+,Tg(Ucp1-cre)1Evdr/0
Genetic Background: involves: 129 * C57BL/6J * FVB
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| MP:0020523 | decreased susceptibility to induced hypothermia | "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262] |
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Allelic Composition: Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0030025 | giant platelets | "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx] |
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac
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| MP:0030066 | short face | "an abnormally decreased height (length) of the face" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0030091 | macrodontia | "abnormal increase in the size of one or more teeth" [HP:0001572, MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Chrna7tm2.1(cre)Swr/Chrna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0030245 | round head | "overall shape of the head is more circular than usual as viewed from the front" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0030258 | small mandibular condyloid process | "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna] |
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6
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| MP:0030278 | thick neurocranium | "increased thickness of the bones of the skull enclosing the brain" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0030283 | small mandibular coronoid process | "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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| MP:0030287 | enlarged occipital bone | "increased size of the bone at the lower, posterior part of the skull" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm5(ASPSCR1/TFE3)Mrc/Gt(ROSA)26Sortm1(cre/ERT)Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0030313 | abnormal face development | "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325] |
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Allelic Composition: Smotm1Amc/Smotm2Amc,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: C57BL/6J * CBA/J
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| MP:0030350 | premature coronal suture closure | "early closure of the coronal suture of the skull" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0030367 | premature metopic suture closure | "early closure of the metopic suture of the skull; premature closure of this suture compromises the transverse growth of both the frontal bones and can cause a narrow, triangular shaped forehead (trigonocephaly) that is associated with orbital hypotelorism" [http://www.skullbaseinstitute.com/craniosynostosis-craniofacial/trigonocephaly.html, PMID:23960302] |
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
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| MP:0030372 | enlarged Meckel s cartilage | "increased size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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