ENSMUSG00000086598


Mus musculus

Features
Gene ID: ENSMUSG00000086598
  
Biological name :Btbd18
  
Synonyms : A0A0A6YY25 / Btbd18 / BTB/POZ domain-containing protein 18
  
Possible biological names infered from orthology : B2RXH4 / BTB domain containing 18
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: D
Gene start: 84659079
Gene end: 84668780
  
Corresponding Affymetrix probe sets: 1438273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142247
NCBI entrez gene - 100270744     See in Manteia.
MGI - MGI:3650217
RefSeq - NM_001145100
RefSeq - XM_006498526
RefSeq Peptide - NP_001138572
swissprot - A0A0A6YY25
Ensembl - ENSMUSG00000086598
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B2RXH4ENSG00000233436Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:1990511 piRNA biosynthetic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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