ENSMUSG00000089727


Mus musculus

Features
Gene ID: ENSMUSG00000089727
  
Biological name :Klra8
  
Synonyms : Killer cell lectin-like receptor 8 / Klra8 / Q60682
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 130115226
Gene end: 130129898
  
Corresponding Affymetrix probe sets: 10548504 (MoGene1.0st)   1425417_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014476
NCBI entrez gene - 16639     See in Manteia.
MGI - MGI:102968
RefSeq - NM_010650
RefSeq - NM_001101620
RefSeq Peptide - NP_001095090
RefSeq Peptide - NP_034780
swissprot - Q60682
Ensembl - ENSMUSG00000089727
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klra9ENSMUSG0000003302485
Klra10ENSMUSG0000007271884
Klra3 / Q64329 / Killer cell lectin-like receptor 3 ENSMUSG0000006759183
Klra6 / Q60653 / Killer cell lectin-like receptor 6 ENSMUSG0000006176973
Klra5 / Q60652 / Killer cell lectin-like receptor 5 ENSMUSG0000003017371
Klra17ENSMUSG0000001454359
Klra4 / Q60651 / Mus musculus killer cell lectin-like receptor, subfamily A, member 18 (Klra18), mRNA.ENSMUSG0000007985258
Klra7 / Q60654 / Killer cell lectin-like receptor 7 ENSMUSG0000006759958
Klra1ENSMUSG0000007985357
Klra2ENSMUSG0000003018747
Gm156 / Mus musculus predicted 156 (Gm156), transcript variant 2, mRNA.ENSMUSG0000007115819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR013600  Ly49-like, N-terminal
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0009615 response to virus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

Allelic Composition: Klra8Cmv1-del/Klra8Cmv1-r
Genetic Background: (BXD8/TyJ x C57BL/6)F1

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3catm3Bvan/Pik3catm3Bvan,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Klra8Cmv1-del/Klra8Cmv1-s
Genetic Background: (BXD8/TyJ x DBA/2)F1

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-gb/Kitl+
Genetic Background: C3.Cg-KitlSl-gb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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