Manteia

ENSMUSG00000090213

Mus musculus

Features

Gene ID:	ENSMUSG00000090213

Biological name :	Tmem189

Synonyms :	Q99LQ7 / Tmem189 / Transmembrane protein 189

Possible biological names infered from orthology :

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	H3
Gene start:	167642608
Gene end:	167689822

Corresponding Affymetrix probe sets:	10489912 (MoGene1.0st) 1424411_at (Mouse Genome 430 2.0 Array) 1427843_at (Mouse Genome 430 2.0 Array) 1451341_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000006587 NCBI entrez gene - 407243 See in Manteia. MGI - MGI:2142624 RefSeq - NM_145538 RefSeq Peptide - NP_663513 swissprot - Q99LQ7 Ensembl - ENSMUSG00000090213

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tmem189	ENSDARG00000042732	Danio rerio
TMEM189	ENSGALG00000026906	Gallus gallus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gm20431 / TMEM189-UBE2V1 readthrough / TMEM189-UBE2V1*	ENSMUSG00000089739	89

Protein motifs (from Interpro)

Interpro ID	Name
IPR019547	B domain of TMEM189, localisation domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0016567	protein ubiquitination	IEA
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IBA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IBA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0000195	hypocalcemia	"subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0002599	increased mean platelet volume	"increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0003442	decreased circulating glycerol level	"lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0003795	abnormal bone structure		Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0004151	hypoferremia	"less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0005478	decreased circulating thyroxine level	"less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0005567	decreased circulating total protein level	"less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0010092	increased circulating magnesium level	"an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0010096	abnormal incisor color	"anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr