ENSMUSG00000092192


Mus musculus

Features
Gene ID: ENSMUSG00000092192
  
Biological name :Dyx1c1
  
Synonyms : Dynein assembly factor 4, axonemal / Dyx1c1 / Q8R368
  
Possible biological names infered from orthology : DNAAF4 / dynein axonemal assembly factor 4 / Q8WXU2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 72958785
Gene end: 72973064
  
Corresponding Affymetrix probe sets: 10587000 (MoGene1.0st)   1451605_at (Mouse Genome 430 2.0 Array)   1459965_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034734
Ensembl peptide - ENSMUSP00000096166
NCBI entrez gene - 67685     See in Manteia.
MGI - MGI:1914935
RefSeq - XM_017313537
RefSeq - NM_001163725
RefSeq - NM_026314
RefSeq - XM_006511382
RefSeq Peptide - NP_080590
RefSeq Peptide - NP_001157197
swissprot - Q8R368
swissprot - E9Q973
Ensembl - ENSMUSG00000092192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnaaf4ENSDARG00000099161Danio rerio
 DNAAF4ENSG00000256061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm44503 / DNAAF4* / Q8WXU2* / dynein axonemal assembly factor 4*ENSMUSG0000008986591


Protein motifs (from Interpro)
Interpro ID Name
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0003341 cilium movement IMP
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007368 determination of left/right symmetry ISO
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0036158 outer dynein arm assembly IMP
 biological_processGO:0036159 inner dynein arm assembly ISO
 biological_processGO:0061136 regulation of proteasomal protein catabolic process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0097730 non-motile cilium ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030331 estrogen receptor binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000440 domed skull 
Show

Allelic Composition: Ap3b2m1J/Ap3b2m1J
Genetic Background: C57BL/6J-Ap3b2m1J/FrkJ

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002767 situs ambiguus "abnormal organ position" [J:62608]
Show

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010476 coronary fistula "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula)" [http://emedicine.medscape.com]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0010854 lung situs inversus "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011069 abnormal brain ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyx1c1tm1.2Jjlo/Dyx1c1tm1.2Jjlo
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011665 d-loop transposition of the great arteries "complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
Show

Allelic Composition: Apctm1Rak/Apc+,Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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