ENSMUSG00000096010


Mus musculus

Features
Gene ID: ENSMUSG00000096010
  
Biological name :Hist4h4
  
Synonyms : Hist4h4 / Histone H4 / P62806
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 136801553
Gene end: 136804415
  
Corresponding Affymetrix probe sets: 10548857 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000136357
NCBI entrez gene - 320332     See in Manteia.
MGI - MGI:2448443
RefSeq - NM_175652
RefSeq Peptide - NP_783583
swissprot - B2RTM0
swissprot - P62806
Ensembl - ENSMUSG00000096010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62806 / Hist1h4h / Histone H4 ENSMUSG00000060981100
P62806 / Hist1h4k / Histone H4 / P62805* / HIST1H4I* / histone cluster 1 H4 family member i*ENSMUSG00000064288100
P62806 / Hist1h4m / Histone H4 ENSMUSG00000069306100
P62806 / Hist1h4c / Histone H4 ENSMUSG00000060678100
P62806 / Hist1h4f / Histone H4 ENSMUSG00000069274100
P62806 / Hist1h4n / histone cluster 1, H4nENSMUSG00000069305100
P62806 / Hist1h4i / Histone H4 / P62805* / histone cluster 1 H4 family member i*ENSMUSG00000060639100
P62806 / Hist2h4 / Histone H4 ENSMUSG00000091405100
P62806 / Hist1h4d / Histone H4 ENSMUSG00000061482100
P62806 / Hist1h4j / Histone H4 ENSMUSG00000067455100
P62806 / Hist1h4a / Histone H4 / P62805* / HIST2H4A* / histone cluster 2 H4 family member a*ENSMUSG00000060093100
P62806 / Hist1h4b / Histone H4 ENSMUSG00000069266100


Protein motifs (from Interpro)
Interpro ID Name
 IPR001951  Histone H4
 IPR004823  TATA box binding protein associated factor (TAF)
 IPR009072  Histone-fold
 IPR019809  Histone H4, conserved site
 IPR035425  CENP-T/Histone H4, histone fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006334 nucleosome assembly ISS
 biological_processGO:0006335 DNA replication-dependent nucleosome assembly ISO
 biological_processGO:0006336 DNA replication-independent nucleosome assembly ISO
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation ISO
 biological_processGO:0051290 protein heterotetramerization ISO
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000786 nucleosome ISO
 cellular_componentGO:0000788 nuclear nucleosome IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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