ENSMUSG00000096145


Mus musculus

Features
Gene ID: ENSMUSG00000096145
  
Biological name :Vkorc1
  
Synonyms : Q9CRC0 / vitamin K epoxide reductase complex, subunit 1 / Vkorc1
  
Possible biological names infered from orthology : AC135050.2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 127893063
Gene end: 127895617
  
Corresponding Affymetrix probe sets: 10568328 (MoGene1.0st)   1452770_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033074
Ensembl peptide - ENSMUSP00000145795
Ensembl peptide - ENSMUSP00000112542
NCBI entrez gene - 27973     See in Manteia.
MGI - MGI:106442
RefSeq - NM_178600
RefSeq Peptide - NP_848715
swissprot - D3YWB2
swissprot - A0A0U1RP21
swissprot - Q9CRC0
Ensembl - ENSMUSG00000096145
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vkorc1ENSDARG00000086183Danio rerio
 AC135050.2ENSG00000255439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm21974 / AC135050.2*ENSMUSG0000003080473
Q6TEK5 / Vkorc1l1 / vitamin K epoxide reductase complex, subunit 1-like 1ENSMUSG0000006673547


Protein motifs (from Interpro)
Interpro ID Name
 IPR012932  Vitamin K epoxide reductase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation ISO
 biological_processGO:0017144 drug metabolic process ISO
 biological_processGO:0017187 peptidyl-glutamic acid carboxylation ISO
 biological_processGO:0042371 vitamin K biosynthetic process ISO
 biological_processGO:0042373 vitamin K metabolic process ISO
 biological_processGO:0050820 positive regulation of coagulation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060348 bone development IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity ISO
 molecular_functionGO:0048038 quinone binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbc1d32b2b2596Clo/Tbc1d32b2b2596Clo
Genetic Background: C57BL/6J-Tbc1d32b2b2596Clo

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npas3tm1Ewb/Npas3tm1Ewb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vkorc1Y139C/Vkorc1Y139C
Genetic Background: involves: Swiss outbred * wild

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Vkorc1tm1.1Jobg/Vkorc1tm1.1Jobg
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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