ENSMUSG00000096727


Mus musculus

Features
Gene ID: ENSMUSG00000096727
  
Biological name :Psmb9
  
Synonyms : proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) / Psmb9
  
Possible biological names infered from orthology : P28065 / proteasome subunit beta 9
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34181988
Gene end: 34187764
  
Corresponding Affymetrix probe sets: 10450145 (MoGene1.0st)   1450696_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128195
Ensembl peptide - ENSMUSP00000133499
Ensembl peptide - ENSMUSP00000134120
NCBI entrez gene - 16912     See in Manteia.
MGI - MGI:1346526
RefSeq - XM_006523730
RefSeq - NM_013585
RefSeq Peptide - NP_038613
swissprot - F6QXK7
swissprot - A0A0R4J256
swissprot - G3UYK5
Ensembl - ENSMUSG00000096727
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmb9aENSDARG00000000656Danio rerio
 PSMB9ENSG00000240065Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psmb6 / Q60692 / Proteasome subunit beta type-6 / P28072* / proteasome subunit beta 6*ENSMUSG0000001828659


Protein motifs (from Interpro)
Interpro ID Name
 IPR000243  Peptidase T1A, proteasome beta-subunit
 IPR001353  Proteasome, subunit alpha/beta
 IPR016050  Proteasome beta-type subunit, conserved site
 IPR023333  Proteasome B-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR034383  Proteasome subunit Beta Type 9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:2000116 regulation of cysteine-type endopeptidase activity IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005839 proteasome core complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001836 abnormal antigen presentation via MHC class I "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0002453 abnormal B lymphocyte antigen presentation "impairment in the ability of B lymphocyte to process and/or present antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Psmb9tm1Stl/Psmb9tm1Stl,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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