Manteia - Molecule gene

ENSMUSG00000097993

Mus musculus

Features

Gene ID:	ENSMUSG00000097993

Biological name :	Ptprv

Synonyms :	Ptprv

Possible biological names infered from orthology :

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	E4
Gene start:	135108497
Gene end:	135132594

Corresponding Affymetrix probe sets:	10357986 (MoGene1.0st) 1449957_at (Mouse Genome 430 2.0 Array)

Cross references:	NCBI entrez gene - 13924 See in Manteia. MGI - MGI:108027 Ensembl - ENSMUSG00000097993

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name

ID

Species

No match

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID

Name

No match

Gene Ontology (GO)

Type

GO ID

Term

Ev.Code

No match

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001148	enlarged testes	"increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001152	Leydig cell hyperplasia	"increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd * STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s Allelic Composition: Lep^ob/Lep^ob,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: involves: 129P2/OlaHsd * STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbx2^tm1Ykf/Cbx2^tm1Ykf Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002673	abnormal sperm count	"increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002781	increased circulating testosterone level	"greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003058	increased insulin secretion	"greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004851	increased testis weight	"greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004892	increased adiponectin level	"greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004909	increased seminal gland weight	"increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0004928	increased epididymis weight	"increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd * STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s
MP:0005491	islet cell hyperplasia	"increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Lep^ob/Lep^ob,Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd * STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0006035	abnormal mitochondrial morphology	"anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006094	adipocyte hypertrophy	"increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006362	abnormal male germ cell morphology	"any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0008280	male germ cell apoptosis	"presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0009113	increased pancreatic beta cell mass	"greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009167	increased pancreatic islet number	"increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009767	decreased sensitivity to xenobiotic induced morbidity/mortality	"increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011819	increased pancreatic beta cell proliferation	"increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ptprv^tm1Asmi/Ptprv^tm1Asmi Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Atf4^tm1Tow/Atf4⁺,Ptprv^tm1Asmi/Ptprv⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)
MP:0030016	increased adipocyte glucose uptake	"increased ability of adipocytes to take in glucose" [MGI:anna]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0030021	increased muscle cell glucose uptake	"increased ability of muscle cells to take in glucose" [MGI:anna]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

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Interaction type

No match

0 s.

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