ENSMUSG00000104213


Mus musculus

Features
Gene ID: ENSMUSG00000104213
  
Biological name :Ighd
  
Synonyms : Ighd
  
Possible biological names infered from orthology : immunoglobulin heavy constant delta / P01880
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 113406604
Gene end: 113416324
  
Corresponding Affymetrix probe sets: 1455530_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141353
Ensembl peptide - ENSMUSP00000141946
MGI - MGI:96447
swissprot - A0A0A6YW14
swissprot - A0A0A6YXD7
Ensembl - ENSMUSG00000104213
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGHDENSG00000211898Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0019815 B cell receptor complex IDA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IMP
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hps5ru2-4Btlr/Hps5ru2-4Btlr
Genetic Background: C57BL/6J-Hps5ru2-4Btlr

Allelic Composition: Ighdm2Btlr/Ighdm2Btlr
Genetic Background: C57BL/6J-Ighdm2Btlr

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: IghdM1Btlr/IghdM1Btlr
Genetic Background: C57BL/6J-IghdM1Btlr

Allelic Composition: IghdM1Btlr/Ighd+
Genetic Background: C57BL/6J-IghdM1Btlr

Allelic Composition: Ighdm2Btlr/Ighdm2Btlr
Genetic Background: C57BL/6J-Ighdm2Btlr

Allelic Composition: Ighdm2Btlr/Ighd+
Genetic Background: C57BL/6J-Ighdm2Btlr

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1tm2Yhi/Zeb1tm2Yhi,Zeb2tm1.2Yhi/Zeb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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