ENSMUSG00000116207


Mus musculus

Features
Gene ID: ENSMUSG00000116207
  
Biological name :Nnt
  
Synonyms : Nnt
  
Possible biological names infered from orthology : nicotinamide nucleotide transhydrogenase / Q13423
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.3
Gene start: 119335528
Gene end: 119408952
  
Corresponding Affymetrix probe sets: 10412394 (MoGene1.0st)   1416105_at (Mouse Genome 430 2.0 Array)   1456573_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152868
MGI - MGI:109279
swissprot - Q8BGK0
Ensembl - ENSMUSG00000116207
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nntENSDARG00000023536Danio rerio
 NNTENSGALG00000014869Gallus gallus
 NNTENSG00000112992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nnt / Q13423* / nicotinamide nucleotide transhydrogenase*ENSMUSG00000025453100


Protein motifs (from Interpro)
Interpro ID Name
 IPR007698  Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
 IPR007886  Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
 IPR008142  Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1
 IPR008143  Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2
 IPR029035  DHS-like NAD/FAD-binding domain superfamily
 IPR034300  NADP transhydrogenase beta-like domain
 IPR036188  FAD/NAD(P)-binding domain superfamily
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psen1tm2Psgh/Psen1tm2Psgh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: NntG745D/NntG745D
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: NntG745D/NntG745D
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: NntG745D/NntG745D
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0008291 abnormal adrenocortical cell morphology "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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