ENSDARG00000001234


Danio rerio

Features
Gene ID: ENSDARG00000001234
  
Biological name :map4k2
  
Synonyms : map4k2 / mitogen-activated protein kinase kinase kinase kinase 2
  
Possible biological names infered from orthology : Q12851 / Q61161
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 17648931
Gene end: 17690983
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000142808
Ensembl peptide - ENSDARP00000015818
NCBI entrez gene - 678610     See in Manteia.
RefSeq - NM_001040358
RefSeq Peptide - NP_001035448
swissprot - A0A1D5NSJ2
swissprot - Q1RLZ2
ZFIN ID - ZDB-GENE-030616-163
Ensembl - ENSDARG00000001234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP4K2ENSG00000168067Homo sapiens
 Map4k2ENSMUSG00000024948Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map4k6 / mitogen-activated protein kinase kinase kinase kinase 6 / Q61161* / MAP4K2* / Q12851* / mitogen-activated protein kinase kinase kinase kinase 2*ENSDARG0000003344467
map4k3b / mitogen-activated protein kinase kinase kinase kinase 3bENSDARG0000007135752
map4k5 / mitogen-activated protein kinase kinase kinase kinase 5 / Q8BPM2*ENSDARG0000003912551
map4k3a / mitogen-activated protein kinase kinase kinase kinase 3a / Q99JP0* / MAP4K3* / Q8IVH8* / mitogen-activated protein kinase kinase kinase kinase 3*ENSDARG0000008774251
mink1 / misshapen-like kinase 1 / Q8N4C8* / Q9JM52* / misshapen-like kinase 1 (zebrafish)*ENSDARG0000003536026
tnika / TRAF2 and NCK interacting kinase a / TNIK* / Q9UKE5* / P83510* / TRAF2 and NCK interacting kinase*ENSDARG0000005621826
map4k4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819*ENSDARG0000009867024
si:zfos-2326c3.2 / NRK* / Q7Z2Y5* / Q9R0G8* / Nik related kinase* / Nik-related protein kinase *ENSDARG0000009868024
CABZ01099833.1 / P70218* / MAP4K1* / Q92918* / mitogen-activated protein kinase kinase kinase kinase 1* / Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), tran...ENSDARG0000011402624
slka / STE20-like kinase a / SLK* / Q9H2G2* / O54988* / STE20 like kinase* / STE20-like serine/threonine-protein kinase *ENSDARG0000006152520
slkb / STE20-like kinase bENSDARG0000001257419
si:dkey-81j8.6ENSDARG0000008883117
stk10 / serine/threonine kinase 10 / O94804*ENSDARG0000010189416
tnikb / TRAF2 and NCK interacting kinase b / TNIK* / Q9UKE5* / P83510* / TRAF2 and NCK interacting kinase*ENSDARG000000090319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR021160  Mitogen-activated protein (MAP) kinase kinase kinase kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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