ENSDARG00000003250


Danio rerio

Features
Gene ID: ENSDARG00000003250
  
Biological name :pik3cd
  
Synonyms : phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta / pik3cd
  
Possible biological names infered from orthology : O00329 / O35904
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 29756603
Gene end: 29812667
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000017757
NCBI entrez gene - 394174     See in Manteia.
RefSeq - NM_201199
RefSeq Peptide - NP_957493
swissprot - F1RB17
ZFIN ID - ZDB-GENE-040426-1128
Ensembl - ENSDARG00000003250
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIK3CDENSGALG00000002583Gallus gallus
 O00329ENSG00000171608Homo sapiens
 O35904ENSMUSG00000039936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *ENSDARG0000007525353
zgc:158659ENSDARG0000006059740
pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *ENSDARG0000007545640
pik3cg / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma / P48736* / Q9JHG7* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform *ENSDARG0000001775731
si:rp71-17i16.5ENSDARG0000003752728
pik3c2a / phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha / O00443*ENSDARG0000006084126
pik3c2b / phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta / O00750*ENSDARG0000008692725
pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*ENSDARG0000005482919
pik3c2g / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma / O75747*ENSDARG0000009980319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation IBA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IMP
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon decreased branchiness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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