ENSDARG00000003699


Danio rerio

Features
Gene ID: ENSDARG00000003699
  
Biological name :atp7a
  
Synonyms : atp7a / ATPase copper transporting alpha
  
Possible biological names infered from orthology : Copper-transporting ATPase 1 / Q04656 / Q64430
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 22397251
Gene end: 22443502
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000145829
Ensembl peptide - ENSDARP00000054976
Ensembl peptide - ENSDARP00000111966
NCBI entrez gene - 564924     See in Manteia.
swissprot - F1Q5B3
swissprot - F1QEG1
ZFIN ID - ZDB-GENE-060825-45
Ensembl - ENSDARG00000003699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP7AENSGALG00000007902Gallus gallus
 ATP7AENSG00000165240Homo sapiens
 Atp7aENSMUSG00000033792Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atp7b / ATPase copper transporting beta / P35670* / Q64446* / Copper-transporting ATPase 2 *ENSDARG0000005814549


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006121  Heavy metal-associated domain, HMA
 IPR006122  Heavy metal-associated domain, copper ion-binding
 IPR008250  P-type ATPase, A domain superfamily
 IPR017969  Heavy-metal-associated, conserved site
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR027256  P-type ATPase, subfamily IB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0010038 response to metal ion IDA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0046688 response to copper ion IMP
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion influx/efflux at host-pathogen interface
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000135 notochord notochord morphology , abnormal
notochord undulate , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium color , abnormal
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 ZFA:0000434 skeletal system skeletal system morphology , abnormal
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 ZFA:0001094 whole organism whole organism morphology , abnormal
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 ZFA:0009091 melanocyte melanocyte intensity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000087693 atox1 / antioxidant 1 copper chaperone / O00244* / O08997* / Copper transport protein ATOX1 *  / reaction
 ENSDARG00000053194 pdzd11 / Q6NXB2 / PDZ domain containing 11 / Q9CZG9* / Q5EBL8* / PDZ domain-containing protein 11 *  / complex






 

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