ENSDARG00000004251


Danio rerio

Features
Gene ID: ENSDARG00000004251
  
Biological name :dhfr
  
Synonyms : dhfr / dihydrofolate reductase
  
Possible biological names infered from orthology : DHFR2 / dihydrofolate reductase 2 / P00374 / P00375 / Q86XF0
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 26138313
Gene end: 26146488
  
Corresponding Affymetrix probe sets: Dr.11722.1.S1_at (Zebrafish Array)   Dr.25786.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000014124
swissprot - A2BGQ1
ZFIN ID - ZDB-GENE-010406-5
Ensembl - ENSDARG00000004251
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DHFRENSGALG00000026757Gallus gallus
 DHFRENSG00000228716Homo sapiens
 DHFR2ENSG00000178700Homo sapiens
 DhfrENSMUSG00000021707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:153031ENSDARG0000006887638


Protein motifs (from Interpro)
Interpro ID Name
 IPR001796  Dihydrofolate reductase domain
 IPR012259  Dihydrofolate reductase
 IPR024072  Dihydrofolate reductase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0003232 bulbus arteriosus development IMP
 biological_processGO:0046654 tetrahydrofolate biosynthetic process IEA
 biological_processGO:0046655 folic acid metabolic process IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060047 heart contraction IMP
 molecular_functionGO:0004146 dihydrofolate reductase activity IDA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle structure , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000092 axis axis anterior region decreased thickness , abnormal
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 ZFA:0000106 extension extension absent , abnormal
extension decreased length , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
heart apoptotic , abnormal
heart position , abnormal
heart malformed , abnormal
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 ZFA:0000155 somite somite shape , abnormal
somite decreased length , abnormal
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 ZFA:0000173 bulbus arteriosus bulbus arteriosus morphology , abnormal
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 ZFA:0000471 atrium atrium structure , abnormal
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 ZFA:0001094 whole organism whole organism apoptotic , abnormal
whole organism hypoplastic , abnormal
whole organism opaque , abnormal
whole organism viability , abnormal
whole organism curved dorsal , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism ventral region edematous , abnormal
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 ZFA:0001114 head head apoptotic , abnormal
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 ZFA:0001115 trunk trunk decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region kinked , abnormal
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 ZFA:0001462 somite border somite border degenerate , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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