ENSDARG00000004451


Danio rerio

Features
Gene ID: ENSDARG00000004451
  
Biological name :tnfrsfa
  
Synonyms : tnfrsfa / tumor necrosis factor receptor superfamily, member a
  
Possible biological names infered from orthology : O00220 / O14763 / O14798 / Q9QZM4 / Q9UBN6 / TNF receptor superfamily member 10a / TNF receptor superfamily member 10b / TNF receptor superfamily member 10c / TNF receptor superfamily member 10d / TNFRSF10A / TNFRSF10B / TNFRSF10C / TNFRSF10D / Tumor necrosis factor receptor superfamily member 10B
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 16172931
Gene end: 16219400
  
Corresponding Affymetrix probe sets: Dr.10712.1.S1_at (Zebrafish Array)   DrAffx.2.54.S1_at (Zebrafish Array)   DrAffx.2.54.S1_s_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000107373
swissprot - F1R567
ZFIN ID - ZDB-GENE-010802-1
Ensembl - ENSDARG00000004451
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDTNFR23ENSGALG00000006407Gallus gallus
 TNFRSF10BENSGALG00000000452Gallus gallus
 O00220ENSG00000104689Homo sapiens
 O14763ENSG00000120889Homo sapiens
 O14798ENSG00000173535Homo sapiens
 Q9UBN6ENSG00000173530Homo sapiens
 Q9QZM4ENSMUSG00000022074Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...ENSDARG0000000439233


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR034024  Tumor necrosis factor receptor 10, N-terminal
 IPR034029  Tumour necrosis factor receptor 10A/B, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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