ENSDARG00000007955


Danio rerio

Features
Gene ID: ENSDARG00000007955
  
Biological name :iars
  
Synonyms : iars / isoleucyl-tRNA synthetase
  
Possible biological names infered from orthology : Isoleucine--tRNA ligase, cytoplasmic / P41252 / Q8BU30
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 1337620
Gene end: 1392468
  
Corresponding Affymetrix probe sets: Dr.5185.1.A1_at (Zebrafish Array)   NM_199896_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000009149
NCBI entrez gene - 334393     See in Manteia.
RefSeq - NM_199896
RefSeq Peptide - NP_956190
swissprot - F1QSY7
ZFIN ID - ZDB-GENE-030131-6325
Ensembl - ENSDARG00000007955
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IARSENSGALG00000004813Gallus gallus
 IARSENSG00000196305Homo sapiens
 IarsENSMUSG00000037851Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002300  Aminoacyl-tRNA synthetase, class Ia
 IPR002301  Isoleucine-tRNA ligase
 IPR009008  Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
 IPR009080  Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
 IPR013155  Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR023586  Isoleucine-tRNA ligase, type 2
 IPR033709  Isoleucyl tRNA synthetase type 2, anticodon-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006428 isoleucyl-tRNA aminoacylation IBA
 biological_processGO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity IEA
 biological_processGO:1903670 regulation of sprouting angiogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002161 aminoacyl-tRNA editing activity IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004822 isoleucine-tRNA ligase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain deformed , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism viability , abnormal
whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head increased amount , abnormal
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 ZFA:0001115 trunk trunk increased amount , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature increased branchiness , abnormal
cranial vasculature angiogenesis increased occurrence , abnormal
cranial vasculature angiogenic sprout increased amount , abnormal
cranial vasculature dorsal region increased branchiness , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel increased branchiness , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature angiogenesis increased occurrence , abnormal
trunk vasculature angiogenic sprout increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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