ENSDARG00000010767


Danio rerio
kinaseepha4ldomainreceptorproteinephrintyrosine-proteinactivitybindingsuperfamilysitephosphorylationsignalingmembranecatalyticsterilealphamotiftypegrowthatptransmembranetyrosinepathwayintegralcomponenteph-ephrinligandserine-threonineclassv

Features
Gene ID: ENSDARG00000010767
  
Biological name :epha4l
  
Synonyms : epha4l / eph receptor A4, like
  
Possible biological names infered from orthology : EPHA4 / EPH receptor A4 / Ephrin type-A receptor 4 / P54764 / Q03137
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 41945310
Gene end: 42039192
  
Corresponding Affymetrix probe sets: Dr.21027.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000003161
NCBI entrez gene - 30687     See in Manteia.
swissprot - F1QJD4
ZFIN ID - ZDB-GENE-990415-61
Ensembl - ENSDARG00000010767
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHA4ENSGALG00000005256Gallus gallus
 EPHA4ENSG00000116106Homo sapiens
 Epha4ENSMUSG00000026235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
epha4b / eph receptor A4bENSDARG0000001160060
ek1 / eph-like kinase 1ENSDARG0000002008060
epha7 / eph receptor A7 / Q15375* / Q61772* / Ephrin type-A receptor 7 *ENSDARG0000000463558
epha3 / eph receptor A3 / P29320*ENSDARG0000003937358
CT990561.1 / EPHA5* / P54756* / EPH receptor A5*ENSDARG0000005828458
epha6 / eph receptor A6 / Q9UF33*ENSDARG0000002297156
ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *ENSDARG0000002153955
ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *ENSDARG0000003737354
ephb3a / eph receptor B3a / EPHB3* / P54753* / P54754* / EPH receptor B3* / Ephrin type-B receptor 3 *ENSDARG0000003154850
ephb4b / eph receptor B4b / EPHB4* / P54760* / P54761* / EPH receptor B4* / Ephrin type-B receptor 4 *ENSDARG0000002711247
ephb4a / eph receptor B4a / EPHB4* / P54760* / P54761* / EPH receptor B4* / Ephrin type-B receptor 4 *ENSDARG0000010072547
epha2a / eph receptor A2 a / Epha2* / Q03145* / Ephrin type-A receptor 2 *ENSDARG0000001735445
epha2b / eph receptor A2 bENSDARG0000002272745
ephb6 / eph receptor B6 / O08644* / Ephrin type-B receptor 6 *ENSDARG0000005772943
ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *ENSDARG0000007675737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabnitrogen compound metabolic processcellular metabolic proccellular metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processcell communicationcell communicationcellular response to stcellular response to stimulus
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic organic cyclic compound bindingheterocyclic coheterocyclic compound bindingsmall molecule small molecule bindingcatalytic activcatalytic activity, acting on a proteintransferase acttransferase activitysignaling recepsignaling receptor activityion bindingion bindingcarbohydrate decarbohydrate derivative bindingdrug bindingdrug binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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